SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 5 ARG A 177
ASP A 214
ASN A 216
TYR A 179
 None
None
None
SO4  A 299 (-4.9A)
 1.47A 1nbiA-3nhiA:
0.0		 1nbiA-3nhiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 5 ARG A 177
ASP A 214
ASN A 216
TYR A 179
 None
None
None
SO4  A 299 (-4.9A)
 1.48A 1nbiB-3nhiA:
0.0		 1nbiB-3nhiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 9 PHE A 259
PHE A 215
VAL A 227
LEU A 231
LEU A 246
 None
 1.38A 1wrkA-3nhiA:
2.8
1wrkB-3nhiA:
3.7		 1wrkA-3nhiA:
14.48
1wrkB-3nhiA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 10 ASP A 202
ASP A 203
THR A 204
ARG A 199
LYS A 207
 None
 1.45A 2j1gE-3nhiA:
undetectable
2j1gF-3nhiA:
undetectable		 2j1gE-3nhiA:
21.31
2j1gF-3nhiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 7 TYR A 179
TYR A 243
ASP A 260
GLU A 263
 SO4  A 299 (-4.9A)
None
None
None
 0.43A 2qebA-3nhiA:
12.0		 2qebA-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 7 TYR A 179
TYR A 243
PHE A 259
ASP A 260
 SO4  A 299 (-4.9A)
None
None
None
 0.67A 2qebA-3nhiA:
12.0		 2qebA-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 7 TYR A 179
TYR A 243
ASP A 260
GLU A 263
 SO4  A 299 (-4.9A)
None
None
None
 0.40A 2qebB-3nhiA:
12.1		 2qebB-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 7 TYR A 179
TYR A 243
PHE A 259
ASP A 260
 SO4  A 299 (-4.9A)
None
None
None
 0.64A 2qebB-3nhiA:
12.1		 2qebB-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 12 TYR A 179
ILE A 191
TYR A 243
ASP A 260
GLU A 263
 SO4  A 299 (-4.9A)
None
None
None
None
 0.65A 2qeoA-3nhiA:
12.0		 2qeoA-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 12 TYR A 179
ILE A 191
TYR A 243
PHE A 259
ASP A 260
 SO4  A 299 (-4.9A)
None
None
None
None
 0.82A 2qeoA-3nhiA:
12.0		 2qeoA-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 10 TYR A 179
ILE A 191
TYR A 243
ASP A 260
GLU A 263
 SO4  A 299 (-4.9A)
None
None
None
None
 0.74A 2qeoB-3nhiA:
12.0		 2qeoB-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 6 LEU A 100
ALA A 116
LEU A 113
ALA A  53
 None
None
None
EAH  A   1 ( 4.3A)
 0.93A 2vcvK-3nhiA:
undetectable		 2vcvK-3nhiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 6 LEU A 127
PRO A  76
GLN A  97
TYR A  96
 None
 1.05A 3vkxA-3nhiA:
undetectable		 3vkxA-3nhiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		3 / 3 TYR A 179
HIS A 157
ARG A 177
 SO4  A 299 (-4.9A)
None
None
 0.94A 4htfA-3nhiA:
undetectable		 4htfA-3nhiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 12 ILE A  75
TYR A 117
VAL A 120
ALA A 116
GLY A 108
 None
EAH  A   1 (-4.6A)
None
None
None
 1.07A 5igiA-3nhiA:
1.7		 5igiA-3nhiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		5 / 12 ILE A  75
TYR A 117
VAL A 120
ALA A 116
GLY A 108
 None
EAH  A   1 (-4.6A)
None
None
None
 1.10A 5igjA-3nhiA:
undetectable		 5igjA-3nhiA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 8 TYR A  82
ILE A  85
LEU A  13
ALA A  12
 None
None
EAH  A   1 (-4.8A)
None
 0.83A 5y7pC-3nhiA:
undetectable		 5y7pC-3nhiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3nhi D7 PROTEIN
(Anopheles
stephensi) 		4 / 8 TYR A  82
ILE A  85
LEU A  13
ALA A  12
 None
None
EAH  A   1 (-4.8A)
None
 0.72A 5y7pE-3nhiA:
undetectable		 5y7pE-3nhiA:
21.02