SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ni8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A  83
PHE A  74
LEU A  65
PHE A 144
LEU A 116
 None
None
None
IPA  A 159 ( 4.8A)
None
 1.05A 1dtlA-3ni8A:
undetectable		 1dtlA-3ni8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 7 LEU A  47
ASP A  40
THR A  39
HIS A  81
 None
 1.19A 1v55C-3ni8A:
undetectable
1v55N-3ni8A:
undetectable
1v55P-3ni8A:
undetectable		 1v55C-3ni8A:
19.47
1v55N-3ni8A:
13.13
1v55P-3ni8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A  70
LEU A  44
THR A  45
LEU A  47
SER A  48
 None
IPA  A 159 ( 4.7A)
None
None
None
 0.98A 2bdmA-3ni8A:
undetectable		 2bdmA-3ni8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 7 ILE A  70
LEU A  65
PHE A  66
THR A 141
 None
 0.92A 3ag2N-3ni8A:
undetectable
3ag2W-3ni8A:
undetectable		 3ag2N-3ni8A:
13.13
3ag2W-3ni8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 7 ILE A  70
LEU A  65
PHE A  66
THR A 141
 None
 0.91A 3ag4N-3ni8A:
undetectable
3ag4W-3ni8A:
undetectable		 3ag4N-3ni8A:
13.13
3ag4W-3ni8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 8 LEU A 114
TRP A 140
LEU A 145
TYR A  27
 None
 1.06A 3v81A-3ni8A:
2.6		 3v81A-3ni8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		5 / 11 GLY A 139
ASN A 143
ARG A  49
PHE A  89
ILE A  70
 None
 1.03A 4j4vA-3ni8A:
undetectable		 4j4vA-3ni8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 8 GLY A 139
ASN A 143
PHE A  89
ILE A  70
 None
 0.79A 4j4vC-3ni8A:
undetectable		 4j4vC-3ni8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 8 ASP A  40
THR A  39
HIS A  81
LEU A  47
 None
 1.15A 5b1bA-3ni8A:
undetectable
5b1bC-3ni8A:
undetectable
5b1bP-3ni8A:
undetectable		 5b1bA-3ni8A:
13.13
5b1bC-3ni8A:
19.47
5b1bP-3ni8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		5 / 12 LEU A 145
GLY A 139
GLU A  85
SER A  98
GLY A  72
 None
None
IPA  A 159 (-3.0A)
None
None
 1.35A 5f9zA-3ni8A:
undetectable		 5f9zA-3ni8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 8 LEU A  47
ASP A  40
THR A  39
HIS A  81
 None
 1.19A 5iy5C-3ni8A:
undetectable
5iy5N-3ni8A:
undetectable
5iy5P-3ni8A:
undetectable		 5iy5C-3ni8A:
18.85
5iy5N-3ni8A:
13.13
5iy5P-3ni8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 8 ASP A  40
THR A  39
HIS A  81
LEU A  47
 None
 1.19A 5wauA-3ni8A:
undetectable
5wauC-3ni8A:
undetectable
5wauc-3ni8A:
undetectable		 5wauA-3ni8A:
13.13
5wauC-3ni8A:
19.47
5wauc-3ni8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 7 ASP A  40
THR A  39
HIS A  81
LEU A  47
 None
 1.19A 5x1bA-3ni8A:
undetectable
5x1bC-3ni8A:
undetectable
5x1bP-3ni8A:
undetectable		 5x1bA-3ni8A:
13.13
5x1bC-3ni8A:
19.47
5x1bP-3ni8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ni8 PFC0360W PROTEIN
(Plasmodium
falciparum) 		4 / 7 ASP A  40
THR A  39
HIS A  81
LEU A  47
 None
 1.17A 6nmfA-3ni8A:
undetectable
6nmfC-3ni8A:
undetectable
6nmfP-3ni8A:
undetectable		 6nmfA-3ni8A:
13.13
6nmfC-3ni8A:
19.47
6nmfP-3ni8A:
19.47