SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 256
PRO A 290
GLY A  56
GLY A 127
GLY A 126
 None
 1.07A 1mxdA-3nioA:
undetectable		 1mxdA-3nioA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 256
PRO A 290
GLY A  56
GLY A 127
GLY A 126
 None
 1.10A 1mxgA-3nioA:
undetectable		 1mxgA-3nioA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.32A 1v8bA-3nioA:
undetectable		 1v8bA-3nioA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.31A 1v8bB-3nioA:
undetectable		 1v8bB-3nioA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.33A 1v8bD-3nioA:
undetectable		 1v8bD-3nioA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 290
GLY A 126
GLY A 127
ASP A 284
PHE A  42
 None
 0.90A 1wg8A-3nioA:
undetectable		 1wg8A-3nioA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 290
GLY A 126
GLY A 127
ASP A 284
PHE A  42
 None
 0.85A 1wg8B-3nioA:
undetectable		 1wg8B-3nioA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 ASP A 284
VAL A 238
ILE A 281
LEU A 280
ILE A 135
 None
 0.95A 2dg9A-3nioA:
undetectable		 2dg9A-3nioA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 ARG A  65
ARG A  62
PHE A  59
GLY A 126
THR A  51
 None
 1.12A 2zxwG-3nioA:
undetectable
2zxwN-3nioA:
undetectable
2zxwO-3nioA:
undetectable		 2zxwG-3nioA:
14.20
2zxwN-3nioA:
21.00
2zxwO-3nioA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.31A 3ce6D-3nioA:
2.2		 3ce6D-3nioA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  93
VAL A  94
GLY A 127
ALA A 104
ILE A  96
 None
 0.97A 3ekpB-3nioA:
undetectable		 3ekpB-3nioA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  93
VAL A  94
GLY A 127
ALA A 104
ILE A  96
 None
 1.01A 3ekpC-3nioA:
undetectable		 3ekpC-3nioA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  93
VAL A  94
GLY A 127
ALA A 104
ILE A  96
 None
 0.97A 3ektB-3nioA:
undetectable		 3ektB-3nioA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.30A 3g1uB-3nioA:
undetectable		 3g1uB-3nioA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		6 / 9 HIS A 154
ASP A 156
ASN A 158
HIS A 168
GLY A 169
THR A 257
 MN  A1602 (-3.3A)
MN  A1601 (-3.0A)
None
None
None
None
 0.64A 3gn0A-3nioA:
24.8		 3gn0A-3nioA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		6 / 9 HIS A 154
ASP A 156
ASN A 158
HIS A 168
GLY A 169
THR A 257
 MN  A1602 (-3.3A)
MN  A1601 (-3.0A)
None
None
None
None
 0.58A 3gn0B-3nioA:
24.9		 3gn0B-3nioA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.32A 3n58C-3nioA:
undetectable		 3n58C-3nioA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.35A 3ondA-3nioA:
2.2		 3ondA-3nioA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.35A 3ondB-3nioA:
undetectable		 3ondB-3nioA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 112
MET A  23
LEU A 306
 None
 0.98A 3vw1D-3nioA:
undetectable		 3vw1D-3nioA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 10 ARG A  65
ARG A  62
PHE A  59
GLY A 127
THR A  51
 None
 1.29A 3wg7G-3nioA:
undetectable
3wg7N-3nioA:
undetectable
3wg7O-3nioA:
undetectable		 3wg7G-3nioA:
14.20
3wg7N-3nioA:
21.00
3wg7O-3nioA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 181
LEU A 136
ILE A 135
THR A 171
 None
 0.88A 4do3B-3nioA:
undetectable		 4do3B-3nioA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 135
GLY A  44
LEU A 306
PHE A 242
THR A 298
 None
 1.20A 4zdyA-3nioA:
undetectable		 4zdyA-3nioA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.34A 5axdA-3nioA:
undetectable		 5axdA-3nioA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.34A 5axdC-3nioA:
undetectable		 5axdC-3nioA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.25A 5m5kB-3nioA:
undetectable		 5m5kB-3nioA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.33A 5m66A-3nioA:
undetectable		 5m66A-3nioA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.31A 5m66C-3nioA:
undetectable		 5m66C-3nioA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 247
VAL A 288
ILE A 271
ALA A 268
VAL A 151
 None
 0.95A 5n0tA-3nioA:
undetectable		 5n0tA-3nioA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.29A 5utuF-3nioA:
undetectable		 5utuF-3nioA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 ARG A  65
ARG A  62
PHE A  59
GLY A 126
THR A  51
 None
 1.13A 5x1bG-3nioA:
undetectable
5x1bN-3nioA:
0.0
5x1bO-3nioA:
undetectable		 5x1bG-3nioA:
14.20
5x1bN-3nioA:
21.00
5x1bO-3nioA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 ARG A  65
ARG A  62
PHE A  59
GLY A 127
THR A  51
 None
 1.29A 5x1bG-3nioA:
undetectable
5x1bN-3nioA:
0.0
5x1bO-3nioA:
undetectable		 5x1bG-3nioA:
14.20
5x1bN-3nioA:
21.00
5x1bO-3nioA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 127
THR A  51
ARG A  65
ARG A  62
PHE A  59
 None
 1.28A 5xdxA-3nioA:
undetectable
5xdxB-3nioA:
undetectable
5xdxT-3nioA:
undetectable		 5xdxA-3nioA:
21.00
5xdxB-3nioA:
22.47
5xdxT-3nioA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 127
THR A  51
ARG A  65
ARG A  62
PHE A  59
 None
 1.28A 5zcoA-3nioA:
0.0
5zcoB-3nioA:
undetectable
5zcoT-3nioA:
undetectable		 5zcoA-3nioA:
21.00
5zcoB-3nioA:
22.47
5zcoT-3nioA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 3nio GUANIDINOBUTYRASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 154
ASP A 245
THR A 255
GLY A 169
HIS A 168
 MN  A1602 (-3.3A)
MN  A1602 (-2.2A)
None
None
None
 1.30A 6f3nB-3nioA:
undetectable		 6f3nB-3nioA:
20.66