SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 132
VAL A 283
VAL A  42
GLY A 123
TYR A 236
 None
 1.38A 1s1uA-3nipA:
undetectable		 1s1uA-3nipA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		4 / 8 MET A 211
PHE A 214
ALA A 265
LEU A 268
 None
 0.77A 2o01A-3nipA:
undetectable		 2o01A-3nipA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 118
PRO A 119
LEU A 310
 None
 0.59A 2po7B-3nipA:
3.0		 2po7B-3nipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
PHE A  23
GLY A  86
ILE A  40
VAL A 122
 None
 1.23A 2zzmA-3nipA:
undetectable		 2zzmA-3nipA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
PHE A  23
GLY A  86
ILE A  40
VAL A 122
 None
 1.29A 2zznA-3nipA:
2.7		 2zznA-3nipA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 165
ASP A 152
HIS A 150
ASP A 148
 None
 1.25A 3c0zA-3nipA:
11.2		 3c0zA-3nipA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 147
VAL A 237
ALA A 280
VAL A 243
THR A 235
 None
 1.06A 3czhA-3nipA:
undetectable		 3czhA-3nipA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 SER A 121
GLY A  89
GLY A  41
LEU A  39
GLN A 111
 None
 1.23A 3fzgA-3nipA:
undetectable		 3fzgA-3nipA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		6 / 9 HIS A 150
ASP A 152
ASN A 154
HIS A 165
GLY A 166
THR A 254
 None
 0.51A 3gn0A-3nipA:
30.5		 3gn0A-3nipA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		6 / 9 HIS A 150
ASP A 152
ASN A 154
HIS A 165
GLY A 166
THR A 254
 None
 0.48A 3gn0B-3nipA:
30.6		 3gn0B-3nipA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 118
PRO A 119
LEU A 310
 None
 0.56A 3hcrA-3nipA:
3.1		 3hcrA-3nipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 102
GLY A  47
VAL A  93
GLY A 124
VAL A 283
 None
 0.86A 3oxvC-3nipA:
undetectable		 3oxvC-3nipA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 102
GLY A  47
VAL A  93
GLY A 123
VAL A 283
 None
 1.04A 3oxwA-3nipA:
undetectable		 3oxwA-3nipA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 102
GLY A  47
VAL A  93
GLY A 124
VAL A 283
 None
 0.87A 3oxwA-3nipA:
undetectable		 3oxwA-3nipA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 187
ASP A 148
VAL A 243
VAL A 184
HIS A 126
 None
 1.37A 4c5nD-3nipA:
3.6		 4c5nD-3nipA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  41
ILE A  40
VAL A 128
SER A 121
 None
 1.09A 4kcnA-3nipA:
undetectable		 4kcnA-3nipA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 282
MET A 144
VAL A 237
ALA A 280
LEU A 120
 None
 1.13A 4rrwA-3nipA:
undetectable		 4rrwA-3nipA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 282
MET A 144
VAL A 237
ALA A 280
LEU A 120
 None
 1.13A 4rrzA-3nipA:
undetectable		 4rrzA-3nipA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 268
ILE A 209
LEU A 217
VAL A 219
THR A 222
 None
 0.71A 4x3mB-3nipA:
undetectable		 4x3mB-3nipA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		4 / 6 GLU A  60
GLY A 293
GLY A 292
ASP A 290
 None
 0.85A 5a06D-3nipA:
2.5		 5a06D-3nipA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 309
ALA A 311
LEU A 277
VAL A  85
 None
 1.20A 5cr1A-3nipA:
undetectable		 5cr1A-3nipA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 290
HIS A 165
ASP A 152
HIS A 150
ASP A 148
 None
 1.27A 5ef8A-3nipA:
11.5		 5ef8A-3nipA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 290
HIS A 165
ASP A 152
HIS A 150
ASP A 148
 None
 1.26A 5ef8B-3nipA:
11.4		 5ef8B-3nipA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 282
MET A 144
VAL A 237
ALA A 280
LEU A 120
 None
 1.12A 5iktA-3nipA:
undetectable		 5iktA-3nipA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 132
PHE A 133
ILE A 105
VAL A 237
MET A 144
 None
 1.34A 5jkwA-3nipA:
undetectable		 5jkwA-3nipA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3nip 3-GUANIDINOPROPIONAS
E
(Pseudomonas
aeruginosa) 		3 / 3 THR A 254
PRO A 168
ARG A 170
 None
 0.87A 5nd7B-3nipA:
undetectable		 5nd7B-3nipA:
20.70