SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.04A 1cqeA-3nixA:
undetectable		 1cqeA-3nixA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.04A 1cqeB-3nixA:
undetectable		 1cqeB-3nixA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.98A 1eqhA-3nixA:
undetectable		 1eqhA-3nixA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.97A 1eqhB-3nixA:
undetectable		 1eqhB-3nixA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PHE A 108
THR A  18
VAL A  19
ALA A 308
 None
None
None
FAD  A 501 (-3.0A)
 0.94A 1fo4B-3nixA:
undetectable		 1fo4B-3nixA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 293
GLY A  12
ALA A  21
ILE A  33
 None
FAD  A 501 (-3.2A)
None
None
 0.79A 1gtnA-3nixA:
undetectable
1gtnB-3nixA:
undetectable		 1gtnA-3nixA:
11.11
1gtnB-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.99A 1gtnB-3nixA:
undetectable
1gtnC-3nixA:
undetectable		 1gtnB-3nixA:
11.11
1gtnC-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 1.03A 1gtnH-3nixA:
undetectable
1gtnI-3nixA:
undetectable		 1gtnH-3nixA:
11.11
1gtnI-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.06A 1gtnM-3nixA:
undetectable
1gtnN-3nixA:
undetectable		 1gtnM-3nixA:
11.11
1gtnN-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 11 ASP A 109
ARG A 105
GLY A 294
THR A 293
GLY A  12
 None
FAD  A 501 (-2.6A)
FAD  A 501 (-3.5A)
None
FAD  A 501 (-3.2A)
 1.33A 1jr1A-3nixA:
undetectable		 1jr1A-3nixA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 8 ASP A 109
ARG A 105
GLY A 294
THR A 293
GLY A  12
 None
FAD  A 501 (-2.6A)
FAD  A 501 (-3.5A)
None
FAD  A 501 (-3.2A)
 1.30A 1jr1B-3nixA:
undetectable		 1jr1B-3nixA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 6 PHE A  39
GLU A 124
GLN A  37
VAL A 127
 None
None
FAD  A 501 (-4.5A)
None
 1.41A 1l2iB-3nixA:
undetectable		 1l2iB-3nixA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 GLU A 334
MET A 341
PHE A 157
ALA A 282
 None
 1.21A 1linA-3nixA:
undetectable		 1linA-3nixA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		3 / 3 SER A 178
GLY A 179
ARG A 183
 None
 0.68A 1t9wA-3nixA:
undetectable		 1t9wA-3nixA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		3 / 3 TYR A 125
ARG A 118
GLN A 119
 None
 0.99A 1tw4A-3nixA:
undetectable		 1tw4A-3nixA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A  12
ALA A  21
ILE A  33
THR A 293
 FAD  A 501 (-3.2A)
None
None
None
 0.81A 1utdF-3nixA:
undetectable
1utdG-3nixA:
undetectable		 1utdF-3nixA:
11.11
1utdG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.00A 1utdP-3nixA:
undetectable
1utdQ-3nixA:
undetectable		 1utdP-3nixA:
11.11
1utdQ-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.02A 1utdT-3nixA:
undetectable
1utdU-3nixA:
undetectable		 1utdT-3nixA:
11.11
1utdU-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 5 PRO A  15
GLY A 294
ASN A 295
GLY A 163
 FAD  A 501 (-4.0A)
FAD  A 501 (-3.5A)
FAD  A 501 (-3.3A)
FAD  A 501 (-3.0A)
 1.10A 1zlqA-3nixA:
undetectable		 1zlqA-3nixA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.96A 2aylA-3nixA:
undetectable		 2aylA-3nixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.02A 2aylB-3nixA:
undetectable		 2aylB-3nixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 LEU A 403
ILE A 407
ILE A 377
HIS A 373
 None
 0.95A 2azxA-3nixA:
undetectable		 2azxA-3nixA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 LEU A 400
PHE A 351
ILE A 399
ASN A 390
 None
 0.90A 2opxA-3nixA:
undetectable		 2opxA-3nixA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 ILE A 345
LEU A 300
PHE A 299
GLY A 307
 None
None
FAD  A 501 (-4.1A)
FAD  A 501 (-3.0A)
 0.83A 2vdbA-3nixA:
undetectable		 2vdbA-3nixA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 9 ILE A  44
GLY A  45
PHE A 222
HIS A 189
ILE A 220
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.0A)
None
None
None
 1.05A 2y7wA-3nixA:
undetectable		 2y7wA-3nixA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 7 ILE A  44
GLY A  45
PHE A 222
HIS A 189
ILE A 220
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.0A)
None
None
None
 1.06A 2y7wC-3nixA:
undetectable		 2y7wC-3nixA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A 293
GLY A 319
GLY A 315
SER A 314
ALA A  21
 None
 0.92A 2yvlA-3nixA:
2.5		 2yvlA-3nixA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 11 GLY A 315
GLY A 318
ILE A  33
SER A  22
VAL A  19
 None
 0.92A 3dcmX-3nixA:
undetectable		 3dcmX-3nixA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 LEU A 292
THR A 293
GLY A 319
ALA A 322
 None
 0.80A 3jusA-3nixA:
undetectable		 3jusA-3nixA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 LEU A 292
THR A 293
GLY A 319
ALA A 322
 None
 0.80A 3jusA-3nixA:
undetectable		 3jusA-3nixA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 358
ILE A 303
PHE A 231
PHE A 238
 None
 0.87A 3ko0B-3nixA:
undetectable
3ko0J-3nixA:
undetectable		 3ko0B-3nixA:
14.32
3ko0J-3nixA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 GLY A 358
ILE A 303
PHE A 231
PHE A 238
 None
 0.86A 3ko0K-3nixA:
undetectable
3ko0S-3nixA:
undetectable		 3ko0K-3nixA:
14.32
3ko0S-3nixA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.07A 3n8xB-3nixA:
undetectable		 3n8xB-3nixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.92A 3n8zA-3nixA:
undetectable		 3n8zA-3nixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.02A 3nt1A-3nixA:
undetectable		 3nt1A-3nixA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.01A 3nt1B-3nixA:
undetectable		 3nt1B-3nixA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.99A 3pghD-3nixA:
undetectable		 3pghD-3nixA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.02A 3rr3A-3nixA:
undetectable		 3rr3A-3nixA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.02A 3rr3B-3nixA:
undetectable		 3rr3B-3nixA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PHE A 325
PHE A 134
ALA A 155
THR A 141
 None
 0.97A 3t3sF-3nixA:
undetectable		 3t3sF-3nixA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ILE A 159
ALA A  13
ALA A 116
GLY A 120
ALA A  20
 None
 1.00A 4enhA-3nixA:
undetectable		 4enhA-3nixA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A  17
GLY A  14
VAL A  19
THR A  18
VAL A  31
 None
FAD  A 501 ( 3.8A)
None
None
None
 1.16A 4f84A-3nixA:
2.4		 4f84A-3nixA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		3 / 4 SER A  94
GLY A 344
GLU A 339
 None
 0.62A 4juoA-3nixA:
undetectable
4juoC-3nixA:
undetectable		 4juoA-3nixA:
21.31
4juoC-3nixA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 ASP A 131
ILE A 132
ASP A 160
ILE A  11
 None
None
None
FAD  A 501 (-4.9A)
 0.93A 4ndnB-3nixA:
undetectable		 4ndnB-3nixA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 ASP A 131
ILE A 132
ASP A 160
ILE A  11
 None
None
None
FAD  A 501 (-4.9A)
 0.96A 4ndnD-3nixA:
undetectable		 4ndnD-3nixA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.00A 4ph9A-3nixA:
undetectable		 4ph9A-3nixA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.99A 4ph9B-3nixA:
undetectable		 4ph9B-3nixA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 6 GLY A 203
GLN A 102
ILE A 206
PHE A  89
 None
 1.06A 4qogA-3nixA:
undetectable
4qogB-3nixA:
undetectable		 4qogA-3nixA:
19.62
4qogB-3nixA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PHE A  61
PHE A 108
GLY A  17
ILE A 159
 None
 0.96A 4qoiA-3nixA:
undetectable
4qoiB-3nixA:
undetectable		 4qoiA-3nixA:
19.62
4qoiB-3nixA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 9 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.01A 4rs0A-3nixA:
undetectable		 4rs0A-3nixA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.18A 4v2yA-3nixA:
undetectable		 4v2yA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.11A 4v2yB-3nixA:
undetectable		 4v2yB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.40A 4v2yC-3nixA:
0.0		 4v2yC-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.17A 4v2zA-3nixA:
undetectable		 4v2zA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.13A 4v2zB-3nixA:
undetectable		 4v2zB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.39A 4v2zC-3nixA:
undetectable		 4v2zC-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.20A 4v30A-3nixA:
undetectable		 4v30A-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.20A 4v30B-3nixA:
undetectable		 4v30B-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.14A 4v32A-3nixA:
undetectable		 4v32A-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.06A 4v32B-3nixA:
0.0		 4v32B-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.34A 4v32C-3nixA:
undetectable		 4v32C-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		3 / 3 ASP A 160
ARG A 105
ARG A  41
 None
FAD  A 501 (-2.6A)
FAD  A 501 (-3.2A)
 0.98A 4x5iA-3nixA:
undetectable		 4x5iA-3nixA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 LEU A 292
VAL A 291
GLY A 315
ALA A  16
PRO A 169
 None
None
None
FAD  A 501 (-3.2A)
None
 1.02A 4xdrA-3nixA:
undetectable		 4xdrA-3nixA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.30A 5amhA-3nixA:
undetectable		 5amhA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.15A 5amiA-3nixA:
undetectable		 5amiA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 8 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.17A 5amiB-3nixA:
undetectable		 5amiB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.16A 5amjA-3nixA:
undetectable		 5amjA-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.12A 5amjB-3nixA:
undetectable		 5amjB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.25A 5amkB-3nixA:
undetectable		 5amkB-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.98A 5eeuF-3nixA:
undetectable
5eeuG-3nixA:
undetectable		 5eeuF-3nixA:
11.11
5eeuG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.96A 5eeuI-3nixA:
undetectable
5eeuJ-3nixA:
undetectable		 5eeuI-3nixA:
11.11
5eeuJ-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.03A 5eeuO-3nixA:
undetectable
5eeuP-3nixA:
undetectable		 5eeuO-3nixA:
11.11
5eeuP-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.03A 5eeuQ-3nixA:
undetectable
5eeuR-3nixA:
undetectable		 5eeuQ-3nixA:
11.11
5eeuR-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.98A 5eevF-3nixA:
undetectable
5eevG-3nixA:
undetectable		 5eevF-3nixA:
11.11
5eevG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.96A 5eevI-3nixA:
undetectable
5eevJ-3nixA:
undetectable		 5eevI-3nixA:
11.11
5eevJ-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.03A 5eevQ-3nixA:
undetectable
5eevR-3nixA:
undetectable		 5eevQ-3nixA:
11.11
5eevR-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.98A 5eewF-3nixA:
undetectable
5eewG-3nixA:
undetectable		 5eewF-3nixA:
11.11
5eewG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.96A 5eewI-3nixA:
undetectable
5eewJ-3nixA:
undetectable		 5eewI-3nixA:
11.11
5eewJ-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 GLY A  12
ALA A  21
ILE A  33
THR A 293
ALA A  20
 FAD  A 501 (-3.2A)
None
None
None
None
 1.03A 5eewQ-3nixA:
undetectable
5eewR-3nixA:
undetectable		 5eewQ-3nixA:
11.11
5eewR-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.98A 5eexF-3nixA:
undetectable
5eexG-3nixA:
undetectable		 5eexF-3nixA:
11.11
5eexG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.99A 5eeyF-3nixA:
undetectable
5eeyG-3nixA:
undetectable		 5eeyF-3nixA:
11.11
5eeyG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.99A 5eezF-3nixA:
undetectable
5eezG-3nixA:
undetectable		 5eezF-3nixA:
11.11
5eezG-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.99A 5ef0F-3nixA:
undetectable
5ef0G-3nixA:
undetectable		 5ef0F-3nixA:
11.11
5ef0G-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 0.99A 5ef1F-3nixA:
undetectable
5ef1G-3nixA:
undetectable		 5ef1F-3nixA:
11.11
5ef1G-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 1.00A 5ef2F-3nixA:
undetectable
5ef2G-3nixA:
undetectable		 5ef2F-3nixA:
11.11
5ef2G-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 10 THR A 293
ALA A  20
GLY A  12
ALA A  21
ILE A  33
 None
None
FAD  A 501 (-3.2A)
None
None
 1.00A 5ef3F-3nixA:
undetectable
5ef3G-3nixA:
undetectable		 5ef3F-3nixA:
11.11
5ef3G-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 6 PHE A 134
SER A 139
VAL A 140
ASP A 131
 None
 1.25A 5hesA-3nixA:
undetectable		 5hesA-3nixA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 6 LEU A 112
CYH A  52
HIS A  55
LEU A  56
 None
 0.69A 5hpuC-3nixA:
undetectable
5hpuD-3nixA:
undetectable		 5hpuC-3nixA:
3.92
5hpuD-3nixA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.98A 5jvzA-3nixA:
undetectable		 5jvzA-3nixA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 0.99A 5jvzB-3nixA:
undetectable		 5jvzB-3nixA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 315
SER A 316
LYS A 317
GLU A 115
GLU A  58
 None
 1.19A 5nwvA-3nixA:
undetectable		 5nwvA-3nixA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.20A 5oh1A-3nixA:
undetectable		 5oh1A-3nixA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.16A 5oh1B-3nixA:
undetectable		 5oh1B-3nixA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.15A 5oh3A-3nixA:
undetectable		 5oh3A-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.10A 5oh3B-3nixA:
undetectable		 5oh3B-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		5 / 11 GLU A 313
GLY A  17
ALA A  16
ALA A  20
VAL A  10
 None
None
FAD  A 501 (-3.2A)
None
None
 1.04A 5yk2A-3nixA:
0.8		 5yk2A-3nixA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nix FLAVOPROTEIN/DEHYDRO
GENASE
(Cytophaga
hutchinsonii) 		4 / 7 ASP A 131
ILE A 132
ASP A 160
ILE A  11
 None
None
None
FAD  A 501 (-4.9A)
 0.93A 6fbnA-3nixA:
undetectable		 6fbnA-3nixA:
22.94