SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3niz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 7 VAL A  82
MET A 101
ARG A 143
LEU A 151
 None
None
None
ADP  A 314 (-4.6A)
 0.90A 1iepB-3nizA:
22.7		 1iepB-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 11 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.23A 1mx1B-3nizA:
undetectable		 1mx1B-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.26A 1mx1C-3nizA:
undetectable		 1mx1C-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 LEU A 281
GLY A 207
VAL A 132
LEU A 125
LEU A 128
 None
 1.25A 1mx1E-3nizA:
undetectable		 1mx1E-3nizA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.78A 1opjA-3nizA:
22.5		 1opjA-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 3.3A)
 1.04A 1opjB-3nizA:
22.5		 1opjB-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 VAL A  37
ALA A  49
LYS A  51
GLU A  69
LEU A  73
VAL A  82
LEU A 151
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
MG  A 312 ( 3.3A)
 0.87A 1t46A-3nizA:
23.1		 1t46A-3nizA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		3 / 3 TYR A 303
ARG A 130
GLN A 127
 None
 1.00A 1tw4A-3nizA:
undetectable		 1tw4A-3nizA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 7 LYS A  51
LEU A  73
ILE A  81
ILE A 140
 ADP  A 314 (-2.8A)
None
None
None
 0.61A 1uwjA-3nizA:
5.8		 1uwjA-3nizA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 9 VAL A  37
LYS A  51
LEU A  84
LEU A  96
MET A 101
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
None
None
 0.78A 1xkkA-3nizA:
22.6		 1xkkA-3nizA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		3 / 3 ARG A 143
ASP A 162
ASP A 104
 None
MG  A 312 ( 3.3A)
ADP  A 314 (-4.1A)
 0.81A 2ejtA-3nizA:
undetectable		 2ejtA-3nizA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
LYS A  51
VAL A  82
PHE A  98
ASN A 149
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
None
MG  A 312 ( 2.9A)
None
MG  A 312 ( 3.3A)
 0.74A 2eufB-3nizA:
31.4		 2eufB-3nizA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
VAL A  82
ASP A 104
ASN A 149
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
None
ADP  A 314 (-4.1A)
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.85A 2eufB-3nizA:
31.4		 2eufB-3nizA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.77A 2hyyC-3nizA:
23.2		 2hyyC-3nizA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 8 LEU A 229
LEU A 252
ASP A 225
ARG A 256
 None
 1.11A 2j2pA-3nizA:
undetectable
2j2pB-3nizA:
undetectable		 2j2pA-3nizA:
18.73
2j2pB-3nizA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 GLY A  30
VAL A  37
ALA A  49
MET A 101
ALA A 161
ASP A 162
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
MG  A 312 ( 3.3A)
 0.74A 2wgjA-3nizA:
23.7		 2wgjA-3nizA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 5 ILE A 293
PHE A 304
VAL A 108
PHE A 273
 None
 1.29A 2ygnA-3nizA:
undetectable		 2ygnA-3nizA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 ALA A  49
LYS A  51
GLU A  69
VAL A  82
MET A 101
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.56A 2zvaA-3nizA:
26.8		 2zvaA-3nizA:
27.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  29
VAL A  37
ALA A  49
LYS A  51
GLU A  69
LEU A  73
MET A 101
 None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
 1.38A 3hegA-3nizA:
27.8		 3hegA-3nizA:
34.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A 298
MET A 284
ILE A 209
LEU A 150
TYR A 303
 None
 1.19A 3ia4A-3nizA:
undetectable		 3ia4A-3nizA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A 298
MET A 284
ILE A 209
LEU A 150
TYR A 303
 None
 1.23A 3ia4B-3nizA:
undetectable		 3ia4B-3nizA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A 298
MET A 284
ILE A 209
LEU A 150
TYR A 303
 None
 1.25A 3ia4C-3nizA:
undetectable		 3ia4C-3nizA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
 0.53A 3ik3A-3nizA:
22.8		 3ik3A-3nizA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
 0.57A 3ik3B-3nizA:
22.6		 3ik3B-3nizA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ASP A 227
LEU A 236
SER A 234
ILE A 269
LEU A 219
 None
 1.26A 3ko0G-3nizA:
undetectable
3ko0H-3nizA:
undetectable
3ko0I-3nizA:
undetectable
3ko0J-3nizA:
undetectable		 3ko0G-3nizA:
15.41
3ko0H-3nizA:
15.41
3ko0I-3nizA:
15.41
3ko0J-3nizA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 8 ALA A  49
LYS A  51
GLU A  69
LEU A  96
MET A 101
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
 0.62A 3lfaA-3nizA:
27.9		 3lfaA-3nizA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 8 VAL A  29
ALA A  49
LYS A  51
GLU A  69
LEU A  96
 None
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
 0.48A 3lfaA-3nizA:
27.9		 3lfaA-3nizA:
33.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 11 ALA A  49
LYS A  51
VAL A  82
PHE A  98
PHE A 100
MET A 101
LEU A 151
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
 0.55A 3miyA-3nizA:
24.8		 3miyA-3nizA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 9 ALA A  49
LYS A  51
PHE A  98
PHE A 100
MET A 101
LEU A 151
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
 0.46A 3miyB-3nizA:
24.5		 3miyB-3nizA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
PHE A 100
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 3.3A)
 1.08A 3ms9A-3nizA:
22.8		 3ms9A-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.93A 3ms9A-3nizA:
22.8		 3ms9A-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
PHE A 100
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 3.3A)
 1.10A 3mssA-3nizA:
16.7		 3mssA-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.96A 3mssA-3nizA:
16.7		 3mssA-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.98A 3mssC-3nizA:
16.6		 3mssC-3nizA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 6 ALA A  66
ILE A  67
VAL A  87
HIS A  89
 None
 1.17A 3nneG-3nizA:
undetectable		 3nneG-3nizA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  29
GLY A  30
VAL A  37
ALA A  49
LYS A  51
LEU A  73
 None
ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
 0.73A 3ohtA-3nizA:
21.2		 3ohtA-3nizA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 VAL A  37
ALA A  49
GLU A  69
LEU A  73
PHE A  98
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
None
None
 0.53A 3rgfA-3nizA:
11.4		 3rgfA-3nizA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 9 ALA A  49
PHE A  98
PHE A 100
ASP A 104
LEU A 151
 ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.1A)
ADP  A 314 (-4.6A)
 0.69A 3ti1A-3nizA:
32.7		 3ti1A-3nizA:
58.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 9 ALA A  49
VAL A  82
PHE A 100
ASP A 104
LYS A 106
LEU A 151
 ADP  A 314 (-3.5A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.1A)
None
ADP  A 314 (-4.6A)
 1.04A 3ti1A-3nizA:
32.7		 3ti1A-3nizA:
58.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 GLY A  32
GLY A  35
VAL A  37
ALA A  49
LYS A  51
VAL A  82
LEU A 151
 ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 (-4.6A)
 0.90A 3v5wA-3nizA:
27.3		 3v5wA-3nizA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 9 VAL A  37
ALA A  49
MET A 101
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.52A 4anqA-3nizA:
24.3		 4anqA-3nizA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 9 VAL A  37
ALA A  49
MET A 101
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.52A 4ansA-3nizA:
24.3		 4ansA-3nizA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 ALA A  49
LYS A  51
GLU A  69
LEU A  73
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.70A 4c8bA-3nizA:
23.6		 4c8bA-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 ALA A  49
LEU A  73
ILE A  81
HIS A 142
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-3.5A)
None
None
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.98A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 ALA A  49
LYS A  51
GLU A  69
LEU A  73
ILE A  81
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.78A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 ALA A  49
LYS A  51
LEU A  73
ILE A  81
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.66A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 VAL A  37
ALA A  49
ASP A 104
ASP A 144
LYS A 146
ASN A 149
LEU A 151
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-4.1A)
None
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
MG  A 312 ( 3.3A)
 0.86A 4i41A-3nizA:
25.5		 4i41A-3nizA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 7 VAL A  37
ALA A  49
MET A 101
ASP A 104
LEU A 151
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.1A)
ADP  A 314 (-4.6A)
 0.78A 4l9iA-3nizA:
9.0		 4l9iA-3nizA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 7 ALA A  49
ASP A 104
ASN A 149
LEU A 151
ASP A 162
 ADP  A 314 (-3.5A)
ADP  A 314 (-4.1A)
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
MG  A 312 ( 3.3A)
 0.71A 4ogrE-3nizA:
31.7		 4ogrE-3nizA:
39.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 GLY A  30
GLY A  32
GLY A  35
VAL A  37
ALA A  49
LYS A  51
VAL A  82
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
 0.78A 4otiA-3nizA:
22.4		 4otiA-3nizA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 GLY A  30
GLY A  32
GLY A  35
VAL A  37
ALA A  49
VAL A  82
LEU A 151
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.6A)
None
 0.63A 4otiA-3nizA:
22.4		 4otiA-3nizA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 VAL A  37
ALA A  49
LYS A  51
PHE A 100
MET A 101
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.84A 4twpB-3nizA:
25.0		 4twpB-3nizA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 12 VAL A  37
ALA A  49
PHE A 100
MET A 101
ASN A 149
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.63A 4twpB-3nizA:
25.0		 4twpB-3nizA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 ALA A  49
GLU A  69
HIS A 142
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 1.16A 4tyjA-3nizA:
23.2		 4tyjA-3nizA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		8 / 11 GLY A  32
VAL A  37
ALA A  49
MET A 101
ASN A 149
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-3.0A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.48A 4u5jA-3nizA:
26.6		 4u5jA-3nizA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
PHE A 100
MET A 101
ASN A 149
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
 0.66A 4wa9B-3nizA:
24.0		 4wa9B-3nizA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
LYS A  51
VAL A  82
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.68A 4xeyA-3nizA:
24.7		 4xeyA-3nizA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ILE A  81
ALA A 161
LEU A 158
SER A 205
ILE A 206
 None
 1.08A 5hi6A-3nizA:
undetectable		 5hi6A-3nizA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 GLY A  30
VAL A  37
ALA A  49
VAL A  82
ASP A 104
LEU A 151
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
ADP  A 314 (-4.1A)
ADP  A 314 (-4.6A)
None
 0.81A 5l2iA-3nizA:
13.6		 5l2iA-3nizA:
45.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 ALA A  49
VAL A  82
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
 0.53A 5mo4A-3nizA:
19.6		 5mo4A-3nizA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 GLU A  27
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
 None
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
 0.96A 5te0A-3nizA:
26.1		 5te0A-3nizA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 LEU A 252
PHE A 233
PHE A 258
ALA A 187
GLY A 222
 None
 1.09A 5veuA-3nizA:
undetectable		 5veuA-3nizA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		5 / 12 GLY A  30
VAL A  37
ALA A  49
PHE A  98
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
 0.50A 5xv7A-3nizA:
30.1		 5xv7A-3nizA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 8 VAL A  37
LYS A  51
PHE A  98
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
MG  A 312 ( 3.3A)
 0.61A 5y9mA-3nizA:
28.9		 5y9mA-3nizA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		4 / 7 VAL A  37
LYS A  51
PHE A  98
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
MG  A 312 ( 3.3A)
 0.74A 5yf9B-3nizA:
28.6		 5yf9B-3nizA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		6 / 12 GLY A  30
VAL A  37
ALA A  49
LYS A  51
LEU A  96
LEU A 151
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 (-4.6A)
 0.89A 5yu9B-3nizA:
22.6		 5yu9B-3nizA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3niz RHODANESE FAMILY
PROTEIN
(Cryptosporidium
parvum) 		7 / 12 VAL A  37
ALA A  49
GLU A  69
VAL A  82
PHE A 100
LEU A 151
ALA A 161
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
ADP  A 314 ( 4.3A)
ADP  A 314 (-4.6A)
None
 0.87A 6hd6A-3nizA:
16.1		 6hd6A-3nizA:
13.64