SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 12 LEU A 297
LEU A 224
VAL A 299
SER A 215
VAL C 372
 None
 1.30A 1db1A-3nk4A:
undetectable		 1db1A-3nk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		3 / 3 ALA A 312
VAL A 323
TRP A 322
 None
 0.97A 1grmA-3nk4A:
undetectable		 1grmA-3nk4A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		4 / 7 GLY A 237
PRO A 235
SER A 239
ALA A  88
 None
 0.99A 1gxsA-3nk4A:
undetectable
1gxsB-3nk4A:
undetectable		 1gxsA-3nk4A:
19.62
1gxsB-3nk4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 12 LEU A 297
LEU A 224
VAL A 299
SER A 215
VAL C 372
 None
 1.38A 1ie9A-3nk4A:
undetectable		 1ie9A-3nk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		3 / 3 ASP A 258
ASP A 254
LYS A 317
 None
 1.14A 1lquB-3nk4A:
undetectable		 1lquB-3nk4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3nk4 ZONA PELLUCIDA 3
ZONA PELLUCIDA 3
(Gallus
gallus;
Gallus
gallus) 		3 / 3 ASP C 371
ASP A 238
ASP A 227
 None
 0.77A 2igtB-3nk4C:
undetectable		 2igtB-3nk4C:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 12 LEU A 127
ALA A  89
SER A 239
PRO A 241
THR A  84
 None
 1.11A 3dfrA-3nk4A:
undetectable		 3dfrA-3nk4A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 10 VAL A 226
ALA A 231
ILE A 293
LEU A 186
PHE A 276
 None
 1.06A 3fl9A-3nk4A:
undetectable		 3fl9A-3nk4A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 10 VAL A 226
ALA A 231
ILE A 293
LEU A 186
PHE A 276
 None
 1.15A 3fl9F-3nk4A:
undetectable		 3fl9F-3nk4A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		4 / 5 HIS A 219
LEU A 297
LEU A 274
ASP A 227
 None
 1.22A 4aqlA-3nk4A:
undetectable		 4aqlA-3nk4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		5 / 12 LEU A 297
VAL C 372
ALA A 212
GLU A 213
PHE A 184
 None
 1.11A 4i1rA-3nk4A:
undetectable		 4i1rA-3nk4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		4 / 8 PHE A 104
SER A  94
THR A 101
ASP A  70
 None
 1.37A 4qb9D-3nk4A:
undetectable		 4qb9D-3nk4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		3 / 3 ALA A  97
ASN A  96
LEU A  95
 None
 0.49A 5i1oA-3nk4A:
undetectable		 5i1oA-3nk4A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		3 / 3 ALA A  97
ASN A  96
LEU A  95
 None
 0.48A 5i1pD-3nk4A:
undetectable		 5i1pD-3nk4A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		4 / 5 LEU A 208
PHE A 276
LEU A 188
PHE A 199
 None
 1.26A 5xdxP-3nk4A:
undetectable
5xdxW-3nk4A:
undetectable		 5xdxP-3nk4A:
21.75
5xdxW-3nk4A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nk4 ZONA PELLUCIDA 3
(Gallus
gallus) 		6 / 12 ILE A 246
ALA A 312
PHE A 276
LEU A 252
ALA A 263
HIS A 296
 None
 1.44A 6a5zL-3nk4A:
undetectable		 6a5zL-3nk4A:
13.19