SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 8 LEU A 192
ALA A 214
VAL A 118
VAL A 146
 None
 0.63A 1epbB-3nk7A:
undetectable		 1epbB-3nk7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 12 GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.88A 1v2xA-3nk7A:
18.8		 1v2xA-3nk7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 12 PHE A 217
GLY A 218
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
 None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.60A 1v2xA-3nk7A:
18.8		 1v2xA-3nk7A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 11 GLY A 218
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.85A 1x7pA-3nk7A:
24.1
1x7pB-3nk7A:
24.4		 1x7pA-3nk7A:
30.52
1x7pB-3nk7A:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 10 ASP A 196
GLY A 218
GLY A 223
ILE A 238
MET A 240
LEU A 247
 None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-4.5A)
 0.51A 1x7pA-3nk7A:
24.1
1x7pB-3nk7A:
24.4		 1x7pA-3nk7A:
30.52
1x7pB-3nk7A:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 9 LEU A 195
GLY A 218
GLY A 223
SER A 237
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-4.5A)
 0.77A 2qmmA-3nk7A:
10.7		 2qmmA-3nk7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 LEU A 195
GLY A 218
GLY A 223
SER A 237
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-4.5A)
 0.85A 2qmmA-3nk7A:
10.7
2qmmB-3nk7A:
10.6		 2qmmA-3nk7A:
21.35
2qmmB-3nk7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 GLY A 218
GLY A 223
ILE A 238
LEU A 247
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.49A 3dcmX-3nk7A:
14.1		 3dcmX-3nk7A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 LEU A 195
GLY A 218
ILE A 238
MET A 240
LEU A 247
SER A 252
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.1A)
 0.43A 3gyqA-3nk7A:
30.7
3gyqB-3nk7A:
33.3		 3gyqA-3nk7A:
73.53
3gyqB-3nk7A:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 GLY A 218
ILE A 255
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 (-3.0A)
None
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.18A 3gyqB-3nk7A:
33.3		 3gyqB-3nk7A:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 11 LEU A 195
GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.39A 3gyqB-3nk7A:
33.3		 3gyqB-3nk7A:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 ASN A 129
GLU A 220
GLY A 222
SER A 246
ASN A 248
VAL A 249
 SAM  A 770 ( 4.1A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-3.9A)
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
 0.86A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		8 / 12 ASN A 129
LEU A 195
GLY A 218
GLU A 220
ILE A 255
ASN A 248
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.25A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		12 / 12 ASN A 129
LEU A 195
THR A 197
GLY A 218
GLU A 220
GLY A 223
ILE A 238
MET A 240
SER A 246
ASN A 248
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.1A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.00A 3nk7A-3nk7A:
44.3		 3nk7A-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		12 / 12 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.31A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		9 / 12 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
ILE A 255
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.37A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 GLU A 220
GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-4.2A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.97A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 9 GLY A 254
ALA A 256
ALA A 142
ASP A 117
LEU A 215
 None
 1.41A 3ur0C-3nk7A:
undetectable		 3ur0C-3nk7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 8 ILE A 145
LEU A 147
VAL A 127
GLY A 128
 None
 0.88A 3w1wA-3nk7A:
2.2		 3w1wA-3nk7A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 12 ALA A 266
ARG A 260
ALA A 142
GLY A 141
LEU A 140
 None
 0.88A 4oaeA-3nk7A:
undetectable		 4oaeA-3nk7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		3 / 3 ARG A 158
ASP A 157
ARG A 159
 None
 0.67A 4wq4B-3nk7A:
undetectable		 4wq4B-3nk7A:
24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 9 GLY A 218
ILE A 238
MET A 240
SER A 246
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-3.7A)
 0.64A 4x3mA-3nk7A:
24.9		 4x3mA-3nk7A:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 9 GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
 0.57A 4x3mB-3nk7A:
24.8		 4x3mB-3nk7A:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 6 PHE A  97
LYS A  95
GLY A  55
TYR A  54
 None
 1.11A 4yshB-3nk7A:
undetectable		 4yshB-3nk7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 GLY A  47
VAL A  48
ALA A 100
LEU A 161
THR A  32
GLY A 166
 None
 1.40A 5hieC-3nk7A:
undetectable		 5hieC-3nk7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 5 PHE A  50
LEU A 161
GLY A 166
ILE A  44
 None
 0.98A 5ik1A-3nk7A:
undetectable		 5ik1A-3nk7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 12 GLY A 218
GLY A 223
ILE A 238
SER A 246
LEU A 247
 SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.57A 5l0zA-3nk7A:
23.9		 5l0zA-3nk7A:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		5 / 11 LEU A 195
ASP A 196
GLY A 218
GLY A 223
LEU A 247
 SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
SAM  A 770 (-4.5A)
 0.63A 5twjD-3nk7A:
8.8		 5twjD-3nk7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		6 / 12 LEU A 195
GLY A 218
GLY A 223
SER A 237
ILE A 238
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-3.8A)
SAM  A 770 (-4.5A)
 1.17A 5zhmB-3nk7A:
7.4		 5zhmB-3nk7A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 5 ILE A 133
SER A 250
ALA A 139
LEU A 171
 None
 1.02A 6dwnA-3nk7A:
undetectable		 6dwnA-3nk7A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3nk7 23S RRNA
METHYLTRANSFERASE
(Streptomyces
actuosus) 		4 / 8 VAL A  81
ASN A   9
ILE A   7
GLU A   3
 None
 1.07A 6hzpA-3nk7A:
undetectable		 6hzpA-3nk7A:
20.36