SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  78
ILE A  12
GLY A  14
ALA A  16
SER A  18
 None
 1.06A 1cqeA-3nksA:
undetectable		 1cqeA-3nksA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  78
ILE A  12
GLY A  14
ALA A  16
SER A  18
 None
 1.07A 1cqeB-3nksA:
undetectable		 1cqeB-3nksA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 LEU A 240
HIS A 243
LEU A  80
LEU A  78
 None
 1.08A 1e7cA-3nksA:
undetectable		 1e7cA-3nksA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  78
ILE A  12
GLY A  14
ALA A  16
SER A  18
 None
 0.97A 1eqhA-3nksA:
undetectable		 1eqhA-3nksA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A  78
ILE A  12
GLY A  14
ALA A  16
SER A  18
 None
 0.98A 1eqhB-3nksA:
undetectable		 1eqhB-3nksA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.41A 1fkoA-3nksA:
2.2		 1fkoA-3nksA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 SER A  18
ALA A  17
ALA A  16
ILE A  12
 None
 0.71A 1gtnI-3nksA:
undetectable
1gtnJ-3nksA:
undetectable		 1gtnI-3nksA:
9.85
1gtnJ-3nksA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 369
ALA A 397
ALA A 393
HIS A 333
ARG A 168
 None
 1.29A 1kt4A-3nksA:
undetectable		 1kt4A-3nksA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 369
ALA A 397
ALA A 393
HIS A 333
ARG A 168
 None
 1.31A 1kt5A-3nksA:
undetectable		 1kt5A-3nksA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 9 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.37A 1lbcB-3nksA:
undetectable		 1lbcB-3nksA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.35A 1lbcA-3nksA:
undetectable
1lbcC-3nksA:
undetectable		 1lbcA-3nksA:
19.96
1lbcC-3nksA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 ALA A 397
ALA A 393
VAL A 314
LEU A 344
ASP A 349
 None
None
None
ACJ  A 478 (-4.0A)
None
 1.12A 1rlbE-3nksA:
undetectable		 1rlbE-3nksA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 4 LEU A  15
SER A  18
TYR A  19
LEU A 240
 None
 1.32A 1xz1A-3nksA:
undetectable		 1xz1A-3nksA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 4 LEU A  15
SER A  18
TYR A  19
LEU A 240
 None
 1.32A 1xz3A-3nksA:
undetectable		 1xz3A-3nksA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 0.98A 2bm9A-3nksA:
2.4		 2bm9A-3nksA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 1.07A 2bm9D-3nksA:
2.1		 2bm9D-3nksA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 1.13A 2br4D-3nksA:
2.1		 2br4D-3nksA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 294
GLU A  34
GLY A   9
ALA A 285
ALA A 447
 None
FAD  A 479 (-3.0A)
FAD  A 479 (-3.3A)
None
None
 1.08A 2br4F-3nksA:
undetectable		 2br4F-3nksA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 9 GLU A 461
LEU A 236
LEU A  74
HIS A  20
ALA A  69
 None
 1.40A 2bxcB-3nksA:
undetectable		 2bxcB-3nksA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A  38
PRO A 287
SER A 450
GLY A  11
 None
None
None
FAD  A 479 (-3.4A)
 1.07A 2qd3A-3nksA:
undetectable		 2qd3A-3nksA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 SER A  13
SER A 462
ALA A  17
GLY A  14
ALA A 285
 FAD  A 479 (-3.0A)
None
None
None
None
 1.25A 2xh9A-3nksA:
undetectable		 2xh9A-3nksA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 SER A  13
SER A 462
ALA A  17
GLY A  14
ALA A 285
 FAD  A 479 (-3.0A)
None
None
None
None
 1.26A 2xh9B-3nksA:
undetectable		 2xh9B-3nksA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 GLU A  55
SER A  45
VAL A 314
HIS A 415
 None
None
None
FAD  A 479 ( 4.9A)
 1.01A 3b9lA-3nksA:
undetectable		 3b9lA-3nksA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 4 VAL A   7
ARG A 464
ILE A  12
THR A 445
 None
 1.40A 3cl9A-3nksA:
undetectable		 3cl9A-3nksA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 VAL A 270
LEU A 294
SER A  18
VAL A 257
ILE A 286
 None
None
None
FAD  A 479 (-3.7A)
FAD  A 479 (-3.9A)
 1.12A 3frqA-3nksA:
undetectable		 3frqA-3nksA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.17A 3h6tA-3nksA:
undetectable
3h6tC-3nksA:
undetectable		 3h6tA-3nksA:
19.96
3h6tC-3nksA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 9 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.22A 3h6tB-3nksA:
undetectable		 3h6tB-3nksA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
 None
 1.14A 3h6tA-3nksA:
undetectable
3h6tC-3nksA:
undetectable		 3h6tA-3nksA:
19.96
3h6tC-3nksA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 ARG A  59
SER A 350
VAL A  46
LEU A  56
 None
 0.83A 3jq7C-3nksA:
4.3		 3jq7C-3nksA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 4 LEU A 203
GLY A 204
GLY A 200
THR A 193
 None
 0.90A 3si7A-3nksA:
undetectable		 3si7A-3nksA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 GLY A 463
LEU A  15
SER A  18
GLU A 452
ALA A 447
 None
None
None
GOL  A 969 (-3.3A)
None
 1.29A 3sxjA-3nksA:
2.9		 3sxjA-3nksA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 7 ILE A  61
ILE A  43
GLU A  83
VAL A  75
 None
 0.87A 3ua5B-3nksA:
undetectable		 3ua5B-3nksA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 SER A 408
ALA A 324
LEU A 363
GLY A 362
ALA A 107
 None
 1.41A 4fe1A-3nksA:
undetectable
4fe1J-3nksA:
undetectable		 4fe1A-3nksA:
21.36
4fe1J-3nksA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 240
ALA A 467
ILE A  12
GLY A  14
GLY A   9
 None
None
None
None
FAD  A 479 (-3.3A)
 1.18A 4hfpB-3nksA:
undetectable		 4hfpB-3nksA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 302
ALA A 299
LEU A 291
LEU A   8
LEU A 262
 None
 1.22A 4j24D-3nksA:
undetectable		 4j24D-3nksA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 VAL A 316
ALA A 315
SER A 313
GLY A 370
THR A 366
 None
 1.31A 4mmaA-3nksA:
1.2		 4mmaA-3nksA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 GLY A 463
GLY A 448
LEU A 446
ILE A  12
ALA A  17
 None
FAD  A 479 (-3.4A)
None
None
None
 1.08A 4qtuB-3nksA:
2.4		 4qtuB-3nksA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 8 ALA A 447
GLY A 463
ALA A  17
GLY A  14
 None
 0.64A 4zjzA-3nksA:
undetectable		 4zjzA-3nksA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 7 GLU A 339
SER A 338
VAL A 335
ARG A 392
 None
 1.45A 5adlA-3nksA:
undetectable
5adlB-3nksA:
undetectable		 5adlA-3nksA:
23.50
5adlB-3nksA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 6 LEU A 326
SER A 350
PRO A 354
PHE A 353
 None
 0.95A 5b8iA-3nksA:
undetectable		 5b8iA-3nksA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.46A 5hbmA-3nksA:
undetectable		 5hbmA-3nksA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 GLU A 278
SER A 276
ARG A 267
GLY A 266
LEU A 262
 None
 1.40A 5m50B-3nksA:
undetectable		 5m50B-3nksA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 291
SER A 276
ARG A 267
GLY A 266
LEU A 262
 None
 1.35A 5m50E-3nksA:
undetectable		 5m50E-3nksA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A   8
GLY A  14
LEU A 291
LEU A 306
LEU A 446
 None
 0.91A 5nfjA-3nksA:
3.5		 5nfjA-3nksA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A   8
GLY A  14
LEU A 291
LEU A 306
LEU A 446
 None
 0.91A 5nfjB-3nksA:
2.4		 5nfjB-3nksA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A   8
GLY A  14
LEU A 291
LEU A 306
LEU A 446
 None
 0.89A 5nfjC-3nksA:
3.1		 5nfjC-3nksA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 415
ILE A 419
GLY A  57
LEU A 344
ALA A 172
 FAD  A 479 ( 4.9A)
ACJ  A 478 (-4.7A)
FAD  A 479 (-3.5A)
ACJ  A 478 (-4.0A)
ACJ  A 478 (-3.2A)
 0.95A 5o96C-3nksA:
undetectable
5o96D-3nksA:
undetectable		 5o96C-3nksA:
20.04
5o96D-3nksA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 233
SER A 462
ARG A  44
GLY A  10
LEU A  15
 None
 1.23A 5ogcB-3nksA:
undetectable		 5ogcB-3nksA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 LEU A 233
VAL A 456
PRO A  58
PHE A 331
GLY A 345
 None
FAD  A 479 (-4.0A)
FAD  A 479 (-3.9A)
ACJ  A 478 (-4.6A)
ACJ  A 478 (-3.6A)
 1.33A 5xiqA-3nksA:
undetectable		 5xiqA-3nksA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 7 SER A 338
VAL A 335
ARG A 392
GLU A 339
 None
 1.46A 6av7A-3nksA:
undetectable
6av7B-3nksA:
undetectable		 6av7A-3nksA:
11.47
6av7B-3nksA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		4 / 5 VAL A   6
THR A   4
LEU A 260
LEU A 442
 None
 0.99A 6bqgA-3nksA:
undetectable		 6bqgA-3nksA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.35A 6bsgA-3nksA:
undetectable		 6bsgA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.30A 6bsiA-3nksA:
undetectable		 6bsiA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.33A 6bsjA-3nksA:
undetectable		 6bsjA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 ILE A 460
PRO A 237
MET A 235
LEU A  74
LEU A  80
 None
 1.32A 6dlzA-3nksA:
2.9
6dlzD-3nksA:
undetectable		 6dlzA-3nksA:
8.39
6dlzD-3nksA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 ILE A 460
PRO A 237
MET A 235
LEU A  74
LEU A  80
 None
 1.32A 6dm1A-3nksA:
3.0
6dm1D-3nksA:
undetectable		 6dm1A-3nksA:
8.39
6dm1D-3nksA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 9 LEU A 236
ILE A  61
PRO A  58
VAL A 456
ILE A  43
 None
None
FAD  A 479 (-3.9A)
FAD  A 479 (-4.0A)
None
 1.08A 6ef6A-3nksA:
undetectable		 6ef6A-3nksA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 12 GLY A  10
GLY A  11
GLN A 238
VAL A 456
CYH A 459
 None
FAD  A 479 (-3.4A)
None
FAD  A 479 (-4.0A)
FAD  A 479 (-3.6A)
 1.10A 6gneA-3nksA:
3.1		 6gneA-3nksA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 11 SER A 228
VAL A 347
GLY A 332
ALA A 107
VAL A 351
 None
ACJ  A 478 (-4.4A)
ACJ  A 478 (-4.4A)
None
None
 1.46A 6hu9A-3nksA:
undetectable
6hu9E-3nksA:
undetectable
6hu9I-3nksA:
undetectable		 6hu9A-3nksA:
23.33
6hu9E-3nksA:
17.51
6hu9I-3nksA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens) 		5 / 10 SER A 228
VAL A 347
GLY A 332
ALA A 107
VAL A 351
 None
ACJ  A 478 (-4.4A)
ACJ  A 478 (-4.4A)
None
None
 1.48A 6hu9L-3nksA:
undetectable
6hu9P-3nksA:
undetectable
6hu9T-3nksA:
undetectable		 6hu9L-3nksA:
23.33
6hu9P-3nksA:
17.51
6hu9T-3nksA:
8.03