SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3nku DRRA
(Legionella
pneumophila) 		4 / 7 LYS A  36
GLU A  39
ALA A  33
ALA A  83
 None
 1.00A 1sn0B-3nkuA:
undetectable
1sn0D-3nkuA:
undetectable		 1sn0B-3nkuA:
21.72
1sn0D-3nkuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3nku DRRA
(Legionella
pneumophila) 		4 / 5 LEU A 192
ALA A 113
VAL A 126
ILE A 160
 None
 0.92A 4xe3B-3nkuA:
undetectable		 4xe3B-3nkuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3nku DRRA
(Legionella
pneumophila) 		4 / 4 VAL A  94
ILE A 160
ASN A 134
VAL A 129
 None
 1.32A 5ajqA-3nkuA:
undetectable		 5ajqA-3nkuA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3nku DRRA
(Legionella
pneumophila) 		3 / 3 LYS A  43
LEU A 136
ASP A  79
 None
 0.57A 5zv2A-3nkuA:
undetectable		 5zv2A-3nkuA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3nku DRRA
(Legionella
pneumophila) 		5 / 12 ILE A  77
ALA A  80
PHE A 130
LEU A 133
ALA A 132
 None
 0.89A 6a5zL-3nkuA:
2.9		 6a5zL-3nkuA:
18.18