SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 9 ILE A  51
LEU A  80
GLU A  11
ALA A  15
VAL A   7
 None
 1.16A 1ctrA-3nnnA:
undetectable		 1ctrA-3nnnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 11 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.87A 1ohrA-3nnnA:
undetectable		 1ohrA-3nnnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 ILE A  18
VAL A 114
LEU A  78
ASP A 106
PHE A 105
 None
 1.33A 1p5zB-3nnnA:
undetectable		 1p5zB-3nnnA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.90A 2nmyA-3nnnA:
undetectable		 2nmyA-3nnnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.86A 3d1xA-3nnnA:
undetectable		 3d1xA-3nnnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.87A 3d1yA-3nnnA:
undetectable		 3d1yA-3nnnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 11 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.84A 3ekxA-3nnnA:
undetectable		 3ekxA-3nnnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.84A 3el4A-3nnnA:
undetectable		 3el4A-3nnnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.78A 3el5B-3nnnA:
undetectable		 3el5B-3nnnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 8 ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
BEF  A 402 (-3.2A)
 0.84A 3el9A-3nnnA:
undetectable		 3el9A-3nnnA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.92A 3s56A-3nnnA:
undetectable		 3s56A-3nnnA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		4 / 7 GLY A  96
ALA A  97
ASP A  98
ILE A  64
 None
 0.78A 3t3cA-3nnnA:
undetectable		 3t3cA-3nnnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.78A 3tkgC-3nnnA:
undetectable		 3tkgC-3nnnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 9 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 1.12A 4njtD-3nnnA:
undetectable		 4njtD-3nnnA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 11 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.88A 4qgiA-3nnnA:
undetectable		 4qgiA-3nnnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3nnn DNA BINDING RESPONSE
REGULATOR D
(Thermotoga
maritima) 		5 / 12 GLY A  96
ALA A  97
ASP A  98
ILE A  64
THR A  81
 None
None
None
None
BEF  A 402 (-3.2A)
 0.87A 5kqxA-3nnnA:
undetectable		 5kqxA-3nnnA:
19.20