SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 5 LEU A  76
LEU A  49
LEU A  38
GLY A  58
 None
 0.86A 1a4lC-3nnsA:
undetectable		 1a4lC-3nnsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.83A 1c6yB-3nnsA:
undetectable		 1c6yB-3nnsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.89A 1c6yB-3nnsA:
undetectable		 1c6yB-3nnsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.82A 1fb7A-3nnsA:
undetectable		 1fb7A-3nnsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.79A 1ohrA-3nnsA:
undetectable		 1ohrA-3nnsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.87A 1sdtB-3nnsA:
undetectable		 1sdtB-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.85A 1sdvB-3nnsA:
undetectable		 1sdvB-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.90A 2avvE-3nnsA:
undetectable		 2avvE-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.86A 2nmyA-3nnsA:
undetectable		 2nmyA-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.93A 2nnpA-3nnsA:
undetectable		 2nnpA-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.84A 2o4sB-3nnsA:
undetectable		 2o4sB-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.84A 2q5kB-3nnsA:
undetectable		 2q5kB-3nnsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.87A 2r5pD-3nnsA:
undetectable		 2r5pD-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.86A 2r5qB-3nnsA:
undetectable		 2r5qB-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 10 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.86A 2r5qD-3nnsA:
undetectable		 2r5qD-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.80A 3d1xA-3nnsA:
undetectable		 3d1xA-3nnsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.81A 3d1yA-3nnsA:
undetectable		 3d1yA-3nnsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		3 / 3 THR A  99
SER A  81
PHE A  90
 None
 0.84A 3d4sA-3nnsA:
undetectable		 3d4sA-3nnsA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
VAL A  47
ILE A  61
 None
 0.80A 3ekwB-3nnsA:
undetectable		 3ekwB-3nnsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.78A 3ekxA-3nnsA:
undetectable		 3ekxA-3nnsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 8 GLY A  93
ALA A  94
ASP A  95
THR A  78
 None
None
None
BEF  A 402 (-3.6A)
 0.62A 3el0A-3nnsA:
undetectable		 3el0A-3nnsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.80A 3el4A-3nnsA:
undetectable		 3el4A-3nnsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.93A 3el4A-3nnsA:
undetectable		 3el4A-3nnsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.71A 3el5B-3nnsA:
undetectable		 3el5B-3nnsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 10 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.94A 3el9B-3nnsA:
undetectable		 3el9B-3nnsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.82A 3s56A-3nnsA:
undetectable		 3s56A-3nnsA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 7 GLY A  93
ALA A  94
ASP A  95
ILE A  61
 None
 0.67A 3t3cA-3nnsA:
undetectable		 3t3cA-3nnsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.68A 3tkgC-3nnsA:
undetectable		 3tkgC-3nnsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.82A 3ufnA-3nnsA:
undetectable		 3ufnA-3nnsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 6 ARG A  63
ILE A  65
VAL A  74
LEU A  49
 None
 1.05A 4em2A-3nnsA:
undetectable		 4em2A-3nnsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 9 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 1.10A 4njtD-3nnsA:
undetectable		 4njtD-3nnsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 VAL A  18
LEU A  22
ILE A  75
VAL A  98
LEU A  77
 None
 1.09A 4o1zB-3nnsA:
undetectable		 4o1zB-3nnsA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 11 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.79A 4qgiA-3nnsA:
undetectable		 4qgiA-3nnsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 7 PHE A  37
GLU A  42
THR A  68
VAL A  47
 None
 0.92A 4wnvD-3nnsA:
undetectable		 4wnvD-3nnsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  61
THR A  78
 None
None
None
None
BEF  A 402 (-3.6A)
 0.83A 5kqxA-3nnsA:
undetectable		 5kqxA-3nnsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 8 LEU A  49
VAL A  47
VAL A   8
PHE A  31
 None
 0.72A 5y9mA-3nnsA:
undetectable		 5y9mA-3nnsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		4 / 8 LEU A  49
VAL A  47
VAL A   8
PHE A  31
 None
 0.66A 5y9mX-3nnsA:
undetectable		 5y9mX-3nnsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.81A 6dj1B-3nnsA:
undetectable		 6dj1B-3nnsA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 3nns DNA BINDING RESPONSE
REGULATOR B
(Thermotoga
maritima) 		5 / 12 GLY A  93
ALA A  94
ASP A  95
ILE A  75
ILE A  61
 None
 0.84A 6dj2B-3nnsA:
undetectable		 6dj2B-3nnsA:
23.36