SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3no4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 ILE A 114
LEU A  85
ASP A  40
GLY A 109
ALA A  68
 None
None
NI  A 300 (-2.4A)
None
None
 1.14A 1axwA-3no4A:
undetectable		 1axwA-3no4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 11 ILE A 114
LEU A  85
ASP A  40
GLY A 109
ALA A  68
 None
None
NI  A 300 (-2.4A)
None
None
 1.02A 1b02A-3no4A:
undetectable		 1b02A-3no4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 ILE A 114
SER A 171
GLY A  26
HIS A  31
LEU A  36
 None
None
None
NI  A 300 (-3.4A)
None
 1.09A 1nbhB-3no4A:
undetectable		 1nbhB-3no4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 5 SER A 216
ARG A 213
HIS A 110
HIS A  71
 None
None
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.1A)
 1.31A 1s19A-3no4A:
undetectable		 1s19A-3no4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.63A 1v7zA-3no4A:
27.2		 1v7zA-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.64A 1v7zB-3no4A:
26.9		 1v7zB-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.64A 1v7zC-3no4A:
27.2		 1v7zC-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.63A 1v7zD-3no4A:
27.0		 1v7zD-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.64A 1v7zE-3no4A:
27.4		 1v7zE-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.63A 1v7zF-3no4A:
27.1		 1v7zF-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 ARG A 213
THR A 176
VAL A 173
GLN A 177
LEU A 220
 None
 1.42A 2fj1A-3no4A:
undetectable		 2fj1A-3no4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 4 HIS A  31
GLU A 172
HIS A 167
HIS A  71
 NI  A 300 (-3.4A)
NI  A 300 (-2.3A)
UNL  A 350 ( 4.4A)
UNL  A 350 ( 4.1A)
 1.20A 2ozrE-3no4A:
undetectable		 2ozrE-3no4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 11 PRO A 218
PRO A 170
THR A 169
GLY A 165
VAL A 193
 None
 1.22A 2uvnB-3no4A:
undetectable		 2uvnB-3no4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.68A 3a6jA-3no4A:
27.3		 3a6jA-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 7 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.71A 3a6jB-3no4A:
26.8		 3a6jB-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.68A 3a6jC-3no4A:
26.9		 3a6jC-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.70A 3a6jE-3no4A:
27.2		 3a6jE-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		6 / 8 GLU A  29
HIS A  31
ASP A  40
HIS A 110
HIS A 167
GLU A 172
 UNL  A 350 ( 4.2A)
NI  A 300 (-3.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.3A)
 0.68A 3a6jF-3no4A:
26.7		 3a6jF-3no4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		3 / 3 THR A  62
ASN A  64
GLU A  45
 None
 0.81A 3v4tA-3no4A:
undetectable
3v4tC-3no4A:
0.6		 3v4tA-3no4A:
22.27
3v4tC-3no4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 LEU A 128
PHE A 104
PHE A 106
VAL A 139
PHE A  23
 None
 0.98A 4c9wA-3no4A:
undetectable		 4c9wA-3no4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 TYR A 125
PHE A 104
PHE A 106
VAL A 139
PHE A  23
 None
 0.87A 4c9wA-3no4A:
undetectable		 4c9wA-3no4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 HIS A 167
ILE A 114
GLY A 109
CYH A  43
GLY A  26
 UNL  A 350 ( 4.4A)
None
None
None
None
 1.02A 4hfpB-3no4A:
undetectable		 4hfpB-3no4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 ILE A 114
GLU A 172
GLY A 109
CYH A  43
GLY A  26
 None
NI  A 300 (-2.3A)
None
None
None
 1.27A 4hfpB-3no4A:
undetectable		 4hfpB-3no4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 11 HIS A  31
HIS A 167
ASP A  40
HIS A 110
GLY A 109
 NI  A 300 (-3.4A)
UNL  A 350 ( 4.4A)
NI  A 300 (-2.4A)
UNL  A 350 ( 4.3A)
None
 1.46A 4qa0B-3no4A:
undetectable		 4qa0B-3no4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 5 HIS A  71
HIS A 167
HIS A 110
ALA A  68
 UNL  A 350 ( 4.1A)
UNL  A 350 ( 4.4A)
UNL  A 350 ( 4.3A)
None
 1.16A 5i3bB-3no4A:
undetectable		 5i3bB-3no4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		5 / 12 GLY A  66
GLY A  32
PHE A 205
GLY A 111
GLY A 112
 None
None
None
UNL  A 350 ( 4.5A)
UNL  A 350 ( 4.6A)
 0.92A 5koxA-3no4A:
undetectable		 5koxA-3no4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 8 HIS A 110
SER A 171
HIS A  31
HIS A 167
 UNL  A 350 ( 4.3A)
None
NI  A 300 (-3.4A)
UNL  A 350 ( 4.4A)
 1.03A 5m8rB-3no4A:
undetectable		 5m8rB-3no4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 8 HIS A 110
SER A 171
HIS A  31
HIS A 167
 UNL  A 350 ( 4.3A)
None
NI  A 300 (-3.4A)
UNL  A 350 ( 4.4A)
 1.00A 5m8rD-3no4A:
undetectable		 5m8rD-3no4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 4 ASP A  40
HIS A  31
HIS A 167
HIS A 110
 NI  A 300 (-2.4A)
NI  A 300 (-3.4A)
UNL  A 350 ( 4.4A)
UNL  A 350 ( 4.3A)
 1.45A 5ncdD-3no4A:
undetectable		 5ncdD-3no4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 8 VAL A 193
PRO A 170
GLY A 219
LEU A 220
 None
 0.93A 5w3jB-3no4A:
4.2		 5w3jB-3no4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		3 / 3 HIS A   4
GLU A  45
ASN A  64
 None
 0.88A 5wbvA-3no4A:
undetectable		 5wbvA-3no4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		3 / 3 HIS A   4
GLU A  45
ASN A  64
 None
 0.89A 5wbvB-3no4A:
undetectable		 5wbvB-3no4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 6 PHE A  74
PRO A  75
GLY A  76
THR A  77
 None
 0.70A 5x24A-3no4A:
undetectable		 5x24A-3no4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 5 VAL A 193
PRO A 210
GLY A 212
TYR A 209
 None
 0.80A 5x80A-3no4A:
undetectable
5x80B-3no4A:
undetectable		 5x80A-3no4A:
25.18
5x80B-3no4A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 7 VAL A 193
PRO A 210
GLY A 212
TYR A 209
 None
 0.85A 5x80C-3no4A:
undetectable
5x80D-3no4A:
undetectable		 5x80C-3no4A:
25.18
5x80D-3no4A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3no4 CREATININE
AMIDOHYDROLASE
(Nostoc
punctiforme) 		4 / 5 PRO A 210
GLY A 212
TYR A 209
VAL A 193
 None
 0.73A 5x80C-3no4A:
undetectable
5x80D-3no4A:
undetectable		 5x80C-3no4A:
25.18
5x80D-3no4A:
25.18