SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3no8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A 523
ARG A 376
ILE A 518
PHE A 406
ILE A 424
 None
 1.35A 1ot7A-3no8A:
undetectable		 1ot7A-3no8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE A 518
PHE A 395
PHE A 499
ILE A 424
 None
 1.07A 2hjhA-3no8A:
undetectable		 2hjhA-3no8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 5 ILE A 518
PRO A 519
PHE A 501
VAL A 521
 None
 1.31A 2hjhB-3no8A:
undetectable		 2hjhB-3no8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 476
VAL A 380
TYR A 386
PHE A 449
 None
 1.15A 2wekA-3no8A:
undetectable		 2wekA-3no8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 SER A 476
VAL A 380
TYR A 386
PHE A 449
 None
 1.14A 2wekB-3no8A:
undetectable		 2wekB-3no8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		4 / 8 GLY A 510
ASN A 509
VAL A 420
TYR A 418
 None
 0.90A 2yoeB-3no8A:
undetectable
2yoeC-3no8A:
undetectable		 2yoeB-3no8A:
18.51
2yoeC-3no8A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY A 510
ASP A 391
SER A 390
 None
 0.72A 3brfA-3no8A:
undetectable		 3brfA-3no8A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ILE A 424
PHE A 406
ILE A 401
VAL A 397
VAL A 459
 None
 1.07A 3me6A-3no8A:
undetectable		 3me6A-3no8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 GLY A 405
PHE A 453
VAL A 397
PHE A 499
PHE A 395
 None
 1.49A 3r6wA-3no8A:
undetectable
3r6wB-3no8A:
undetectable		 3r6wA-3no8A:
19.09
3r6wB-3no8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 10 VAL A 397
PHE A 499
PHE A 395
GLY A 405
PHE A 453
 None
 1.46A 3r6wA-3no8A:
undetectable
3r6wB-3no8A:
undetectable		 3r6wA-3no8A:
19.09
3r6wB-3no8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 412
SER A 411
GLY A 410
HIS A 477
THR A 416
 None
 1.23A 3r75A-3no8A:
undetectable		 3r75A-3no8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 412
SER A 411
GLY A 410
HIS A 477
THR A 416
 None
 1.23A 3r75B-3no8A:
undetectable		 3r75B-3no8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ILE A 412
SER A 411
GLY A 410
HIS A 477
THR A 416
 None
 1.27A 3r76A-3no8A:
undetectable		 3r76A-3no8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 ILE A 412
SER A 411
GLY A 410
HIS A 477
THR A 416
 None
 1.30A 3r76B-3no8A:
undetectable		 3r76B-3no8A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 9 ILE A 424
GLY A 434
PHE A 453
VAL A 521
GLY A 405
 None
 1.41A 4acaB-3no8A:
undetectable
4acaC-3no8A:
undetectable		 4acaB-3no8A:
16.60
4acaC-3no8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER A 390
THR A 389
CYH A 468
ALA A 505
GLY A 506
 None
 1.37A 5l5zH-3no8A:
undetectable
5l5zI-3no8A:
undetectable		 5l5zH-3no8A:
17.41
5l5zI-3no8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 12 SER A 390
THR A 389
CYH A 468
ALA A 505
GLY A 506
 None
 1.38A 5l5zV-3no8A:
undetectable
5l5zW-3no8A:
undetectable		 5l5zV-3no8A:
17.41
5l5zW-3no8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLN A 419
ILE A 412
HIS A 413
 None
 0.61A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLN A 419
ILE A 412
HIS A 477
 None
 0.58A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY A 405
LEU A 408
ALA A 469
PHE A 453
ALA A 467
 None
 1.16A 6qgbA-3no8A:
undetectable		 6qgbA-3no8A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens) 		5 / 11 GLY A 405
LEU A 408
ALA A 469
PHE A 453
ALA A 467
 None
 1.16A 6qgbE-3no8A:
undetectable		 6qgbE-3no8A:
15.49