SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3noy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 GLY A 105
GLU A 137
ASN A 103
 None
 0.57A 1zq9A-3noyA:
undetectable		 1zq9A-3noyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.79A 2rkgA-3noyA:
undetectable		 2rkgA-3noyA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.79A 3nu4B-3noyA:
undetectable		 3nu4B-3noyA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 10 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.79A 3s43B-3noyA:
undetectable		 3s43B-3noyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.85A 3ucbA-3noyA:
undetectable		 3ucbA-3noyA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.76A 3ucbB-3noyA:
undetectable		 3ucbB-3noyA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 157
ILE A 175
GLN A 182
ILE A 189
TYR A 146
 None
 1.45A 4a79A-3noyA:
undetectable		 4a79A-3noyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 11 LEU A 157
ILE A 175
GLN A 182
ILE A 189
TYR A 146
 None
 1.46A 4a7aA-3noyA:
undetectable		 4a7aA-3noyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 PHE A 163
VAL A 127
MET A  93
ILE A 100
 None
 0.91A 4a97I-3noyA:
undetectable		 4a97I-3noyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 VAL A 127
MET A  93
ILE A 100
GLU A 164
 None
 1.10A 4a97I-3noyA:
undetectable		 4a97I-3noyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 VAL A 241
THR A 245
GLU A 244
GLU A 248
 None
 1.43A 4l78A-3noyA:
undetectable		 4l78A-3noyA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 GLY A  96
ILE A  79
THR A  33
VAL A  12
ILE A  53
 None
 0.94A 4q5mA-3noyA:
undetectable		 4q5mA-3noyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 LEU A 235
GLY A 208
ILE A 249
VAL A 241
THR A 245
 None
 1.39A 4x3mA-3noyA:
undetectable		 4x3mA-3noyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 LEU A 157
ALA A 186
ASN A 187
ILE A 175
 None
 1.15A 4y03B-3noyA:
undetectable		 4y03B-3noyA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.88A 5e5jB-3noyA:
undetectable		 5e5jB-3noyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.92A 5t8hA-3noyA:
undetectable		 5t8hA-3noyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 198
GLY A 201
ILE A  23
GLY A 220
ILE A 221
 None
 0.89A 5t8hB-3noyA:
undetectable		 5t8hB-3noyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 PHE A 163
THR A 169
ASP A 195
ASN A 187
 None
 1.29A 5ybbA-3noyA:
undetectable		 5ybbA-3noyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 THR A   7
THR A 169
LYS A 121
GLU A 164
 None
 1.10A 6c06C-3noyA:
undetectable		 6c06C-3noyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 ASP A 341
ILE A 331
PRO A 330
LEU A 324
 None
 1.47A 6mkeB-3noyA:
undetectable		 6mkeB-3noyA:
13.62