SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3npe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 4 THR A 490
LEU A 512
LEU A 468
GLN A 472
 None
 1.26A 1fbmA-3npeA:
undetectable		 1fbmA-3npeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 7 LEU A 229
LEU A 238
ILE A 206
GLU A  99
 None
 1.06A 1n13I-3npeA:
undetectable
1n13L-3npeA:
undetectable		 1n13I-3npeA:
10.91
1n13L-3npeA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 4 LEU A 139
SER A 583
LEU A 565
LEU A 180
 None
 1.15A 1yajA-3npeA:
undetectable		 1yajA-3npeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 4 GLY A 277
SER A 189
VAL A 152
LEU A 279
 None
 1.25A 1yajB-3npeA:
undetectable		 1yajB-3npeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 LEU A 139
SER A 583
LEU A 565
LEU A 180
 None
 1.14A 1yajD-3npeA:
undetectable		 1yajD-3npeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 GLN A 202
PHE A 211
PHE A 230
GLY A 237
 None
 1.37A 2qmzA-3npeA:
undetectable
2qmzB-3npeA:
undetectable		 2qmzA-3npeA:
18.70
2qmzB-3npeA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 8 ALA A 158
ALA A 250
SER A 263
GLY A 246
 None
OH  A   2 ( 4.1A)
None
None
 0.90A 2vh3B-3npeA:
undetectable		 2vh3B-3npeA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		5 / 12 ALA A 508
LEU A 450
LEU A 476
SER A 505
GLY A 429
 None
 1.23A 3lbdA-3npeA:
undetectable		 3lbdA-3npeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		5 / 12 ASN A 156
GLY A 591
VAL A 152
ARG A 483
THR A 195
 None
 1.14A 3mnoA-3npeA:
undetectable		 3mnoA-3npeA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		5 / 12 ASN A 156
GLY A 591
VAL A 152
ARG A 483
THR A 195
 None
 1.15A 3mnpA-3npeA:
undetectable		 3mnpA-3npeA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 8 ARG A 204
ALA A 198
ASP A 174
TYR A 269
 None
 0.83A 3qj7A-3npeA:
undetectable
3qj7D-3npeA:
undetectable		 3qj7A-3npeA:
18.27
3qj7D-3npeA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.44A 3qx3A-3npeA:
undetectable		 3qx3A-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.42A 3qx3B-3npeA:
undetectable		 3qx3B-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		3 / 3 ARG A 208
GLU A 100
ARG A 233
 None
 0.85A 4mwvA-3npeA:
4.9		 4mwvA-3npeA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		5 / 11 GLU A 477
ALA A 496
LEU A 495
LEU A 450
LEU A 468
 None
 1.14A 4wg0I-3npeA:
undetectable
4wg0J-3npeA:
undetectable
4wg0K-3npeA:
undetectable		 4wg0I-3npeA:
4.90
4wg0J-3npeA:
4.90
4wg0K-3npeA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 8 ALA A 117
PRO A 114
GLY A 216
GLY A 220
 None
 0.65A 4zjzA-3npeA:
undetectable		 4zjzA-3npeA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 6 PHE A 102
SER A 222
ALA A 225
HIS A 221
 None
 1.17A 5dzkB-3npeA:
undetectable
5dzkP-3npeA:
undetectable		 5dzkB-3npeA:
17.39
5dzkP-3npeA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 6 PHE A 102
SER A 222
ALA A 225
HIS A 221
 None
 1.18A 5dzkg-3npeA:
undetectable
5dzku-3npeA:
undetectable		 5dzkg-3npeA:
17.39
5dzku-3npeA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 PRO A 469
THR A 514
GLN A 472
THR A 518
 None
 1.28A 5h5fA-3npeA:
undetectable		 5h5fA-3npeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.46A 5zrfB-3npeA:
undetectable		 5zrfB-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 4 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.50A 5zrfA-3npeA:
undetectable		 5zrfA-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 4 PRO A 582
MET A 176
GLY A 157
VAL A 130
 None
None
None
DIO  A2947 ( 4.7A)
 1.27A 6ak3A-3npeA:
undetectable		 6ak3A-3npeA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC
(Zea
mays) 		4 / 6 SER A 333
TYR A 325
ASP A 329
GLN A 290
 None
 1.23A 6djzA-3npeA:
undetectable		 6djzA-3npeA:
19.11