SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3npf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ILE A 180
ASP A 245
PHE A 306
 GOL  A 332 ( 4.8A)
None
None
 0.64A 1uwjB-3npfA:
undetectable		 1uwjB-3npfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 8 ILE A 179
SER A 178
ASP A 175
LEU A 307
 None
 0.89A 2cdqA-3npfA:
undetectable		 2cdqA-3npfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 7 SER A  39
SER A 197
VAL A 130
LYS A 199
 None
 1.37A 2j9cA-3npfA:
undetectable
2j9cB-3npfA:
undetectable
2j9cC-3npfA:
undetectable		 2j9cA-3npfA:
19.08
2j9cB-3npfA:
19.08
2j9cC-3npfA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		5 / 11 LEU A 206
VAL A 201
GLY A 195
HIS A 263
ALA A 276
 CSA  A 203 ( 4.4A)
None
None
CSA  A 203 ( 4.1A)
CSA  A 203 ( 4.1A)
 1.17A 2yy8A-3npfA:
undetectable
2yy8B-3npfA:
undetectable		 2yy8A-3npfA:
20.19
2yy8B-3npfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 GLU A 121
SER A 162
VAL A 108
 None
 0.72A 3eeoA-3npfA:
undetectable		 3eeoA-3npfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ALA A 131
VAL A 107
TRP A 168
 None
 0.81A 3l8lC-3npfA:
undetectable
3l8lD-3npfA:
undetectable		 3l8lC-3npfA:
6.88
3l8lD-3npfA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 8 TYR A 227
PHE A 302
ARG A 299
ARG A 251
 None
 1.17A 3mjrD-3npfA:
undetectable		 3mjrD-3npfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 VAL A 129
SER A 127
LEU A  59
 None
 0.72A 3n8xA-3npfA:
undetectable		 3n8xA-3npfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		5 / 12 LEU A 211
ILE A 266
ALA A 183
ILE A 189
GLY A 195
 None
 1.06A 3nxuA-3npfA:
undetectable		 3nxuA-3npfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 7 TYR A 191
ASP A 202
SER A 204
HIS A 263
 CSA  A 203 ( 4.5A)
GOL  A 329 (-3.3A)
GOL  A 329 (-3.5A)
CSA  A 203 ( 4.1A)
 1.34A 4arcA-3npfA:
undetectable		 4arcA-3npfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ARG A 134
TRP A 100
GLY A  60
 None
 1.03A 4e7cA-3npfA:
undetectable		 4e7cA-3npfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 6 HIS A 263
GLY A 250
ARG A 299
ASN A 296
 CSA  A 203 ( 4.1A)
None
None
None
 1.32A 4zbqA-3npfA:
undetectable		 4zbqA-3npfA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ASP A  78
ARG A 220
TYR A  80
 None
GOL  A 329 (-3.5A)
GOL  A 329 (-4.7A)
 1.06A 5a7mA-3npfA:
undetectable		 5a7mA-3npfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 6 ILE A 232
VAL A 247
ASP A 245
ALA A 303
 None
 0.88A 5cu6A-3npfA:
undetectable		 5cu6A-3npfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		5 / 12 VAL A 201
ILE A 274
LEU A 206
GLY A 205
TYR A 184
 None
None
CSA  A 203 ( 4.4A)
CSA  A 203 ( 4.5A)
GOL  A 332 ( 4.1A)
 1.16A 5ienA-3npfA:
undetectable		 5ienA-3npfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ARG A 169
PHE A 212
ARG A 134
 None
 1.02A 5y9yA-3npfA:
undetectable		 5y9yA-3npfA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ARG A 251
GLY A 260
GLU A 259
 None
 0.63A 6fgdA-3npfA:
undetectable		 6fgdA-3npfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		4 / 7 ASP A  79
GLN A  75
LYS A  64
TYR A 325
 GOL  A 337 (-2.9A)
None
None
None
 1.17A 6g31G-3npfA:
undetectable		 6g31G-3npfA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ASN A 322
PRO A  77
GLN A  75
 GOL  A 337 ( 4.1A)
None
None
 0.72A 6jnhA-3npfA:
undetectable		 6jnhA-3npfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI
(Bacteroides
ovatus) 		3 / 3 ASN A 322
PRO A  77
GLN A  75
 GOL  A 337 ( 4.1A)
None
None
 0.72A 6jogA-3npfA:
undetectable		 6jogA-3npfA:
19.47