SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3npg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 171
LEU A 214
SER A  92
ILE A  96
LEU A  98
 ACT  A 251 (-3.2A)
None
None
None
None
 1.26A 1dreA-3npgA:
undetectable		 1dreA-3npgA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 234
VAL A 175
TYR A  31
ASN A  89
VAL A  85
 None
None
ACT  A 251 (-4.2A)
None
None
 1.26A 1x70A-3npgA:
undetectable		 1x70A-3npgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 SER A 241
PHE A 234
VAL A 175
TYR A  31
ASN A  89
 None
None
None
ACT  A 251 (-4.2A)
None
 1.35A 1x70A-3npgA:
undetectable		 1x70A-3npgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ASP A 154
VAL A 139
PRO A 125
 None
 0.78A 2avvA-3npgA:
undetectable		 2avvA-3npgA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 GLY A  84
LEU A  83
ILE A  61
PHE A  25
LEU A  22
 None
 1.00A 2f8dA-3npgA:
undetectable		 2f8dA-3npgA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A  47
ILE A 174
ASN A  89
ILE A  88
 None
 1.03A 2h4jA-3npgA:
7.0		 2h4jA-3npgA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 VAL A 128
ILE A 168
TYR A 244
MET A 217
 None
 1.49A 3gvuA-3npgA:
undetectable		 3gvuA-3npgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 179
ALA A 169
VAL A 164
ILE A 182
 None
 0.94A 3wsjB-3npgA:
undetectable		 3wsjB-3npgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 171
LEU A 214
SER A  92
ILE A  96
LEU A  98
 ACT  A 251 (-3.2A)
None
None
None
None
 1.08A 4ky8A-3npgA:
undetectable		 4ky8A-3npgA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 171
LEU A 214
SER A  92
ILE A  96
LEU A  98
 ACT  A 251 (-3.2A)
None
None
None
None
 1.14A 4ky8D-3npgA:
undetectable		 4ky8D-3npgA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 171
LEU A 214
SER A  92
ILE A  96
LEU A  98
 ACT  A 251 (-3.2A)
None
None
None
None
 1.12A 4ky8E-3npgA:
2.3		 4ky8E-3npgA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  88
THR A 212
LEU A 201
LEU A 183
LEU A   5
 None
 1.47A 4qynB-3npgA:
undetectable		 4qynB-3npgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 LEU A 201
LEU A  98
SER A 216
LEU A 214
ILE A 246
 None
 1.23A 4ubsA-3npgA:
undetectable		 4ubsA-3npgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A   9
ASP A  74
ALA A  73
ILE A  88
SER A  92
 None
 1.15A 4uroC-3npgA:
undetectable		 4uroC-3npgA:
21.80