SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3npi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 GLU A  71
ARG A  74
ARG A  75
LEU A  27
 None
SO4  A 257 (-2.8A)
None
None
 0.75A 1cmaA-3npiA:
undetectable
1cmaB-3npiA:
undetectable		 1cmaA-3npiA:
19.34
1cmaB-3npiA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		4 / 6 ILE A 176
ARG A 175
TYR A 105
PHE A 102
 None
 1.46A 1e73M-3npiA:
undetectable		 1e73M-3npiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 9 GLU A  71
ARG A  74
ARG A  75
LEU A  27
ALA A  26
 None
SO4  A 257 (-2.8A)
None
None
None
 1.12A 1mj2C-3npiA:
undetectable		 1mj2C-3npiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 9 GLU A  71
ARG A  74
ARG A  75
LEU A  27
ALA A  26
 None
SO4  A 257 (-2.8A)
None
None
None
 1.09A 1mjoA-3npiA:
undetectable		 1mjoA-3npiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 9 GLU A  71
ARG A  74
ARG A  75
LEU A  27
ALA A  26
 None
SO4  A 257 (-2.8A)
None
None
None
 1.09A 1mjoB-3npiA:
1.1		 1mjoB-3npiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 9 GLU A  71
ARG A  74
ARG A  75
LEU A  27
ALA A  26
 None
SO4  A 257 (-2.8A)
None
None
None
 1.10A 1mjoC-3npiA:
undetectable		 1mjoC-3npiA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		3 / 3 ASP A  24
LEU A  27
HIS A 103
 None
 0.71A 1qknA-3npiA:
undetectable		 1qknA-3npiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		4 / 5 ILE A 176
LEU A  76
ALA A 111
GLU A 110
 None
 1.22A 1xvaA-3npiA:
undetectable
1xvaB-3npiA:
undetectable		 1xvaA-3npiA:
23.99
1xvaB-3npiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		4 / 8 TYR A 223
SER A 217
SER A 213
ARG A 156
 None
 1.22A 2vmyA-3npiA:
undetectable
2vmyB-3npiA:
undetectable		 2vmyA-3npiA:
20.48
2vmyB-3npiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.13A 3rr3D-3npiA:
undetectable		 3rr3D-3npiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.03A 5ikqA-3npiA:
undetectable		 5ikqA-3npiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.06A 5ikqB-3npiA:
undetectable		 5ikqB-3npiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3npi TETR FAMILY
REGULATORY PROTEIN
(Corynebacterium
diphtheriae) 		5 / 12 ARG A  95
VAL A 207
LEU A 211
VAL A  91
GLY A  93
 None
 1.00A 5ikrB-3npiA:
undetectable		 5ikrB-3npiA:
21.26