SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 8 ASP A  67
ASP A  63
HIS A  62
HIS A  20
 None
MN  A 300 (-2.6A)
MN  A 300 (-3.5A)
None
 0.95A 1ei6C-3nqwA:
undetectable		 1ei6C-3nqwA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3nqw CG11900
(Drosophila
melanogaster) 		5 / 12 LEU A 169
ASP A 126
VAL A  40
HIS A  36
ALA A 116
 None
None
None
MN  A 300 (-3.5A)
None
 1.40A 2g70A-3nqwA:
undetectable		 2g70A-3nqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3nqw CG11900
(Drosophila
melanogaster) 		5 / 12 LEU A 169
ASP A 126
VAL A  40
HIS A  36
ALA A 116
 None
None
None
MN  A 300 (-3.5A)
None
 1.43A 2g70B-3nqwA:
undetectable		 2g70B-3nqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 8 LYS A 124
ASN A 127
HIS A  36
ILE A 119
 None
MN  A 300 ( 4.2A)
MN  A 300 (-3.5A)
None
 1.08A 3kp6A-3nqwA:
undetectable
3kp6B-3nqwA:
undetectable		 3kp6A-3nqwA:
25.65
3kp6B-3nqwA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3nqw CG11900
(Drosophila
melanogaster) 		3 / 3 ARG A 101
LYS A 102
LYS A  98
 None
SO4  A 301 (-2.8A)
SO4  A 301 (-3.1A)
 1.23A 4k50A-3nqwA:
undetectable		 4k50A-3nqwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3nqw CG11900
(Drosophila
melanogaster) 		3 / 3 ARG A 101
LYS A 102
LYS A  98
 None
SO4  A 301 (-2.8A)
SO4  A 301 (-3.1A)
 1.17A 4k50E-3nqwA:
undetectable		 4k50E-3nqwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3nqw CG11900
(Drosophila
melanogaster) 		3 / 3 ARG A 101
LYS A 102
LYS A  98
 None
SO4  A 301 (-2.8A)
SO4  A 301 (-3.1A)
 1.22A 4k50I-3nqwA:
undetectable		 4k50I-3nqwA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nqw CG11900
(Drosophila
melanogaster) 		5 / 12 ILE A  50
VAL A  55
LEU A  44
VAL A  90
ALA A 116
 None
 1.27A 4m11C-3nqwA:
undetectable		 4m11C-3nqwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nqw CG11900
(Drosophila
melanogaster) 		5 / 12 ILE A  50
VAL A  55
LEU A  44
VAL A  90
ALA A 116
 None
 1.30A 4m11D-3nqwA:
undetectable		 4m11D-3nqwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 5 LEU A 158
ILE A 106
LYS A 102
GLN A 105
 None
None
SO4  A 301 (-2.8A)
None
 0.88A 4ma8C-3nqwA:
undetectable		 4ma8C-3nqwA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3nqw CG11900
(Drosophila
melanogaster) 		3 / 3 ASP A  82
GLY A  54
ASP A  52
 None
 0.38A 4xdtA-3nqwA:
undetectable		 4xdtA-3nqwA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 6 VAL A  34
HIS A  20
HIS A  62
LEU A  60
 None
None
MN  A 300 (-3.5A)
None
 1.28A 5hrqH-3nqwA:
undetectable
5hrqK-3nqwA:
undetectable
5hrqL-3nqwA:
undetectable		 5hrqH-3nqwA:
12.42
5hrqK-3nqwA:
11.02
5hrqL-3nqwA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 5 ASN A 127
ASP A 126
ASN A  39
ASN A 134
 MN  A 300 ( 4.2A)
None
None
None
 1.45A 5vooC-3nqwA:
undetectable		 5vooC-3nqwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nqw CG11900
(Drosophila
melanogaster) 		4 / 5 ASN A 127
ASP A 126
ASN A  39
ASN A 134
 MN  A 300 ( 4.2A)
None
None
None
 1.41A 5vooE-3nqwA:
undetectable		 5vooE-3nqwA:
22.30