SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 5 LEU A 358
LEU A 367
SER A 502
LEU A 495
 None
 1.02A 1a4lC-3nqxA:
undetectable		 1a4lC-3nqxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 GLY A 365
ALA A 370
THR A 352
SER A 372
 None
None
None
ZN  A   1 ( 4.9A)
 0.90A 1c9sT-3nqxA:
undetectable
1c9sU-3nqxA:
undetectable		 1c9sT-3nqxA:
14.98
1c9sU-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 GLY A 365
ALA A 370
THR A 352
SER A 372
 None
None
None
ZN  A   1 ( 4.9A)
 0.84A 1gtfL-3nqxA:
undetectable
1gtfM-3nqxA:
undetectable		 1gtfL-3nqxA:
14.98
1gtfM-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 GLY A 365
ALA A 370
THR A 352
SER A 372
 None
None
None
ZN  A   1 ( 4.9A)
 0.82A 1gtfN-3nqxA:
undetectable
1gtfO-3nqxA:
undetectable		 1gtfN-3nqxA:
14.98
1gtfO-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 4 ASP A 373
HIS A 345
ARG A 403
GLU A 369
 None
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.3A)
 0.85A 1lqtA-3nqxA:
0.9		 1lqtA-3nqxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 9 HIS A 345
TYR A 360
HIS A 349
GLU A 346
ARG A 403
 ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
None
 1.24A 1nkiA-3nqxA:
undetectable
1nkiB-3nqxA:
undetectable		 1nkiA-3nqxA:
18.69
1nkiB-3nqxA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.16A 1v7zA-3nqxA:
undetectable		 1v7zA-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.16A 1v7zB-3nqxA:
undetectable		 1v7zB-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.17A 1v7zC-3nqxA:
undetectable		 1v7zC-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.17A 1v7zD-3nqxA:
undetectable		 1v7zD-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.16A 1v7zE-3nqxA:
undetectable		 1v7zE-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.17A 1v7zF-3nqxA:
undetectable		 1v7zF-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 PHE A 268
ASN A 266
TYR A 259
HIS A 310
 None
 1.24A 1wu8A-3nqxA:
undetectable
1wu8C-3nqxA:
undetectable		 1wu8A-3nqxA:
24.22
1wu8C-3nqxA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 ALA A 370
ARG A 403
TYR A 422
TYR A 421
 None
 1.20A 2ajvH-3nqxA:
undetectable
2ajvL-3nqxA:
undetectable		 2ajvH-3nqxA:
21.45
2ajvL-3nqxA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 ALA A 318
HIS A 345
GLU A 346
HIS A 349
GLU A 369
 None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-3.2A)
ZN  A   1 (-2.3A)
 0.42A 2c6nA-3nqxA:
6.9		 2c6nA-3nqxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 HIS A 345
GLU A 346
HIS A 349
GLU A 369
TYR A 429
 ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-3.2A)
ZN  A   1 (-2.3A)
None
 1.10A 2c6nB-3nqxA:
6.3		 2c6nB-3nqxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 ASN A 279
ASP A 280
THR A 223
GLY A 222
 None
 0.69A 2f6dA-3nqxA:
undetectable		 2f6dA-3nqxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 VAL A 338
SER A 343
LEU A 278
HIS A 282
 None
 1.07A 2f78A-3nqxA:
undetectable		 2f78A-3nqxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 6 VAL A 338
SER A 343
LEU A 278
HIS A 282
 None
 1.17A 2f8dA-3nqxA:
0.5		 2f8dA-3nqxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.14A 3a6jA-3nqxA:
undetectable		 3a6jA-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 7 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.13A 3a6jB-3nqxA:
undetectable		 3a6jB-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.13A 3a6jC-3nqxA:
undetectable		 3a6jC-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.15A 3a6jE-3nqxA:
undetectable		 3a6jE-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 8 GLU A 369
HIS A 345
HIS A 428
HIS A 349
GLU A 346
 ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
 1.13A 3a6jF-3nqxA:
undetectable		 3a6jF-3nqxA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 GLY A 392
ASN A 317
ALA A 318
LEU A 340
ASP A 373
 None
 1.18A 3ckkA-3nqxA:
undetectable		 3ckkA-3nqxA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A303_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 4 ASN A 361
SER A 430
SER A 414
ARG A 403
 None
 1.46A 3hlwA-3nqxA:
0.0		 3hlwA-3nqxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		3 / 3 HIS A 345
GLU A 346
HIS A 349
 ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-3.2A)
 0.19A 3kecB-3nqxA:
3.1		 3kecB-3nqxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 TYR A 434
VAL A 455
ASN A 475
GLY A 476
 None
 1.15A 3kmoB-3nqxA:
undetectable		 3kmoB-3nqxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 PHE A 371
GLU A 380
GLY A 376
ASN A 387
ILE A 288
 None
CA  A 511 (-2.3A)
None
None
None
 1.41A 3ps9A-3nqxA:
undetectable		 3ps9A-3nqxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 LEU A 340
PHE A 327
ALA A 281
GLY A 285
ILE A 288
 None
 1.11A 3qpsA-3nqxA:
undetectable		 3qpsA-3nqxA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 PHE A 327
ALA A 281
PHE A 284
GLY A 285
ILE A 288
 None
 1.03A 3qpsA-3nqxA:
undetectable		 3qpsA-3nqxA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 6 HIS A 349
GLU A 369
ASP A 373
SER A 431
 ZN  A   1 (-3.2A)
ZN  A   1 (-2.3A)
None
None
 0.91A 4apjA-3nqxA:
6.5
4apjP-3nqxA:
undetectable		 4apjA-3nqxA:
20.03
4apjP-3nqxA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.44A 4feuA-3nqxA:
undetectable
4feuB-3nqxA:
0.0		 4feuA-3nqxA:
22.36
4feuB-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.20A 4feuB-3nqxA:
0.0
4feuE-3nqxA:
0.0		 4feuB-3nqxA:
22.36
4feuE-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.14A 4fevA-3nqxA:
0.0		 4fevA-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 ASP A 411
ASN A 435
GLU A 377
GLU A 369
 None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.20A 4fevB-3nqxA:
undetectable		 4fevB-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 7 ASP A 411
ASN A 435
GLU A 377
GLU A 369
 None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.21A 4fewB-3nqxA:
undetectable		 4fewB-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.21A 4fexD-3nqxA:
0.0		 4fexD-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 ASP A 411
ASN A 435
GLU A 377
GLU A 369
 None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.18A 4gkhD-3nqxA:
undetectable		 4gkhD-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.16A 4gkhI-3nqxA:
0.0
4gkhJ-3nqxA:
0.0		 4gkhI-3nqxA:
22.36
4gkhJ-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 ASP A 411
ARG A 413
ASN A 435
GLU A 377
GLU A 369
 None
None
None
CA  A 511 (-2.7A)
ZN  A   1 (-2.3A)
 1.19A 4gkiK-3nqxA:
0.0
4gkiL-3nqxA:
0.0		 4gkiK-3nqxA:
22.36
4gkiL-3nqxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 HIS A 428
TYR A 360
GLU A 369
HIS A 345
ASN A 317
 None
None
ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
 1.44A 4ir0A-3nqxA:
undetectable
4ir0B-3nqxA:
undetectable		 4ir0A-3nqxA:
16.83
4ir0B-3nqxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 HIS A 428
TYR A 360
GLU A 369
HIS A 345
ASN A 317
 None
None
ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
 1.50A 4jd1A-3nqxA:
undetectable
4jd1B-3nqxA:
undetectable		 4jd1A-3nqxA:
16.83
4jd1B-3nqxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 HIS A 345
ASN A 317
HIS A 428
TYR A 360
GLU A 369
 ZN  A   1 (-3.2A)
None
None
None
ZN  A   1 (-2.3A)
 1.43A 4jd1A-3nqxA:
undetectable
4jd1B-3nqxA:
undetectable		 4jd1A-3nqxA:
16.83
4jd1B-3nqxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 HIS A 428
TYR A 360
GLU A 369
HIS A 345
ASN A 317
 None
None
ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
 1.46A 4jh3A-3nqxA:
undetectable
4jh3B-3nqxA:
undetectable		 4jh3A-3nqxA:
17.92
4jh3B-3nqxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 HIS A 345
ASN A 317
HIS A 428
TYR A 360
GLU A 369
 ZN  A   1 (-3.2A)
None
None
None
ZN  A   1 (-2.3A)
 1.44A 4jh3A-3nqxA:
undetectable
4jh3B-3nqxA:
undetectable		 4jh3A-3nqxA:
17.92
4jh3B-3nqxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 HIS A 428
TYR A 360
GLU A 369
HIS A 345
ASN A 317
 None
None
ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
 1.48A 4jh4A-3nqxA:
undetectable
4jh4B-3nqxA:
undetectable		 4jh4A-3nqxA:
17.92
4jh4B-3nqxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 HIS A 428
TYR A 360
GLU A 369
HIS A 345
ASN A 317
 None
None
ZN  A   1 (-2.3A)
ZN  A   1 (-3.2A)
None
 1.44A 4jh5A-3nqxA:
undetectable
4jh5B-3nqxA:
undetectable		 4jh5A-3nqxA:
17.92
4jh5B-3nqxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 HIS A 345
ASN A 317
HIS A 428
TYR A 360
GLU A 369
 ZN  A   1 (-3.2A)
None
None
None
ZN  A   1 (-2.3A)
 1.47A 4jh5A-3nqxA:
undetectable
4jh5B-3nqxA:
undetectable		 4jh5A-3nqxA:
17.92
4jh5B-3nqxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 HIS A 282
ASN A 241
ASN A 286
ILE A 288
 None
 0.89A 4k0bA-3nqxA:
undetectable		 4k0bA-3nqxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 HIS A 282
ASN A 241
ASN A 286
ILE A 288
 None
 0.91A 4l7iA-3nqxA:
undetectable		 4l7iA-3nqxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 6 HIS A 345
HIS A 349
TYR A 360
GLU A 369
 ZN  A   1 (-3.2A)
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.3A)
 0.91A 4pahA-3nqxA:
undetectable		 4pahA-3nqxA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 VAL A 498
GLN A 418
GLY A 366
GLY A 365
ASN A 361
 None
 1.05A 4zvmA-3nqxA:
undetectable
4zvmB-3nqxA:
undetectable		 4zvmA-3nqxA:
21.52
4zvmB-3nqxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5eevL-3nqxA:
undetectable
5eevV-3nqxA:
undetectable		 5eevL-3nqxA:
14.98
5eevV-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5eewL-3nqxA:
undetectable
5eewV-3nqxA:
undetectable		 5eewL-3nqxA:
14.98
5eewV-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5eezL-3nqxA:
undetectable
5eezV-3nqxA:
undetectable		 5eezL-3nqxA:
14.98
5eezV-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5ef1L-3nqxA:
undetectable
5ef1V-3nqxA:
undetectable		 5ef1L-3nqxA:
14.98
5ef1V-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5ef2L-3nqxA:
undetectable
5ef2V-3nqxA:
undetectable		 5ef2L-3nqxA:
14.98
5ef2V-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 8 THR A 352
SER A 372
GLY A 365
ALA A 370
 None
ZN  A   1 ( 4.9A)
None
None
 0.83A 5ef3L-3nqxA:
undetectable
5ef3V-3nqxA:
undetectable		 5ef3L-3nqxA:
14.98
5ef3V-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 12 GLU A 377
GLY A 376
ILE A 288
ASP A 373
ALA A 375
 CA  A 511 (-2.7A)
None
None
None
None
 1.23A 5kvaA-3nqxA:
undetectable		 5kvaA-3nqxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 LEU A 367
GLY A 365
GLY A 362
VAL A 433
ALA A 370
 None
 1.13A 5o96E-3nqxA:
undetectable
5o96F-3nqxA:
undetectable		 5o96E-3nqxA:
20.50
5o96F-3nqxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 10 HIS A 345
TYR A 360
HIS A 349
GLU A 346
ARG A 403
 ZN  A   1 (-3.2A)
None
ZN  A   1 (-3.2A)
ZN  A   1 ( 4.5A)
None
 1.24A 5v3dA-3nqxA:
undetectable
5v3dB-3nqxA:
0.0		 5v3dA-3nqxA:
19.16
5v3dB-3nqxA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 ALA A 480
TYR A 434
LEU A 495
TRP A 447
ALA A 459
 None
 1.43A 6dk1B-3nqxA:
undetectable		 6dk1B-3nqxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		5 / 11 ALA A 480
TYR A 434
LEU A 495
TRP A 447
ALA A 459
 None
 1.50A 6dk1C-3nqxA:
undetectable		 6dk1C-3nqxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3nqx SECRETED
METALLOPROTEASE
MCP02
(Pseudoalteromona
s
sp.
SM9913) 		4 / 6 MET A 374
ALA A 494
LEU A 441
ALA A 442
 None
 1.10A 6fosB-3nqxA:
undetectable		 6fosB-3nqxA:
14.76