SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 6 LEU A  43
VAL A 118
VAL A  53
GLN A  56
 None
 1.12A 1e7aB-3nr1A:
undetectable		 1e7aB-3nr1A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 7 LEU A 164
ILE A  42
ALA A  15
ILE A  33
 None
 0.81A 2xkwA-3nr1A:
undetectable		 2xkwA-3nr1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 8 ALA A  80
GLY A  79
ARG A  84
GLN A  81
 None
 0.90A 3rglA-3nr1A:
undetectable		 3rglA-3nr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A  49
VAL A  54
LEU A  43
VAL A  89
ALA A 115
 None
 1.27A 4m11C-3nr1A:
undetectable		 4m11C-3nr1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A  49
VAL A  54
LEU A  43
VAL A  89
ALA A 115
 None
 1.29A 4m11D-3nr1A:
undetectable		 4m11D-3nr1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 5 GLY A 159
THR A 160
GLY A 156
GLU A 165
 None
 1.10A 4v20A-3nr1A:
undetectable		 4v20A-3nr1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		3 / 3 ARG A 128
ASP A 129
ARG A 132
 None
 0.57A 4wq4B-3nr1A:
undetectable		 4wq4B-3nr1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens) 		4 / 8 GLN A 104
VAL A 118
ASP A 122
TYR A 125
 None
None
MN  A 199 (-2.8A)
None
 0.92A 5vlmA-3nr1A:
undetectable		 5vlmA-3nr1A:
20.71