SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  37
PRO A  39
THR A  54
ARG A 127
TYR A 129
 SO4  A 903 (-3.6A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.25A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.86A 1cbrA-3nr3A:
19.0		 1cbrA-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ALA A  37
PRO A  39
THR A  54
ARG A 127
TYR A 129
 SO4  A 903 (-3.6A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.25A 1cbrB-3nr3A:
19.0		 1cbrB-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.86A 1cbrB-3nr3A:
19.0		 1cbrB-3nr3A:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.85A 1cbsA-3nr3A:
18.9		 1cbsA-3nr3A:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
PRO A  39
THR A  54
ARG A 127
TYR A 129
 None
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.6A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.88A 2fr3A-3nr3A:
19.1		 2fr3A-3nr3A:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  67
VAL A  85
ILE A  52
ILE A  43
MET A   2
 None
 1.14A 2gj5A-3nr3A:
5.9		 2gj5A-3nr3A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 105
GLU A  73
LEU A  24
TYR A  20
ALA A  76
 PLM  A 901 ( 4.5A)
None
None
None
PLM  A 901 ( 4.0A)
 1.22A 2noaA-3nr3A:
undetectable		 2noaA-3nr3A:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		10 / 12 PHE A  17
VAL A  26
SER A  56
THR A  61
ALA A  76
ASP A  77
ARG A  79
CYH A 118
ARG A 127
TYR A 129
 None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.56A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		8 / 12 PHE A  17
VAL A  26
SER A  56
THR A  61
ALA A  76
ASP A  77
CYH A 125
TYR A 129
 None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
 1.32A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 TYR A  20
MET A  21
PRO A  39
ILE A 105
 None
PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.5A)
 0.54A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		11 / 12 PHE A  17
TYR A  20
VAL A  26
SER A  56
THR A  61
ALA A  76
ARG A  79
ILE A 105
CYH A 118
ARG A 127
TYR A 129
 None
None
None
PLM  A 901 (-3.7A)
None
PLM  A 901 ( 4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.63A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		7 / 12 PHE A  17
VAL A  26
SER A  56
ALA A  76
CYH A 125
ARG A 127
TYR A 129
 None
None
PLM  A 901 (-3.7A)
PLM  A 901 ( 4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.49A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 TYR A  20
VAL A  26
THR A  54
ARG A  79
ILE A 105
 None
None
PLM  A 901 ( 4.6A)
None
PLM  A 901 ( 4.5A)
 1.22A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 MET A  21
PRO A  39
ASP A  77
ARG A 107
 PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
PLM  A 901 (-3.7A)
 0.41A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 7 PHE A   5
LEU A  92
LEU A  67
LEU A  87
 None
 0.73A 3bgdB-3nr3A:
undetectable		 3bgdB-3nr3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 4 ARG A 107
ASP A  19
GLY A 122
THR A 103
 PLM  A 901 (-3.7A)
SO4  A 904 (-3.7A)
None
None
 1.05A 3k4vB-3nr3A:
undetectable		 3k4vB-3nr3A:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		11 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 107
CYH A 118
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 (-3.7A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.58A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		8 / 12 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
CYH A 125
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.17A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		6 / 7 PHE A  17
MET A  21
ASP A  77
ILE A 105
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
PLM  A 901 (-4.0A)
PLM  A 901 ( 4.5A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.51A 3p6hA-3nr3A:
25.3		 3p6hA-3nr3A:
58.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 8 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PLM  A 901 ( 4.6A)
None
 0.87A 4n16A-3nr3A:
undetectable		 4n16A-3nr3A:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 6 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
 0.78A 4qztA-3nr3A:
20.4		 4qztA-3nr3A:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 6 TYR A  20
GLU A  73
THR A  75
GLN A  96
 None
 0.77A 4qzuC-3nr3A:
20.5		 4qzuC-3nr3A:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		6 / 12 PHE A  17
TYR A  20
VAL A  26
PRO A  39
ILE A  52
SER A  56
 None
None
None
SO4  A 903 ( 4.8A)
None
PLM  A 901 (-3.7A)
 0.62A 5hbsA-3nr3A:
19.8		 5hbsA-3nr3A:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.97A 5ljbA-3nr3A:
19.8		 5ljbA-3nr3A:
35.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.96A 5ljcA-3nr3A:
19.9		 5ljcA-3nr3A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 3nr3 PMP2 PROTEIN
(Homo
sapiens) 		4 / 7 GLN A  96
PHE A  71
THR A  54
THR A  61
 None
None
PLM  A 901 ( 4.6A)
None
 0.91A 5m78A-3nr3A:
undetectable		 5m78A-3nr3A:
19.48