SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E73_M_ASCM995_0 (MYROSINASE MA1)	3nr5	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG (Homo sapiens)	4 / 6	ILE A 50 TYR A 121 PHE A 142 PHE A 130	None	1.21A	1e73M-3nr5A: undetectable	1e73M-3nr5A: 15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_D_ROFD904_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3nr5	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG (Homo sapiens)	3 / 3	ASN A 140 MET A 1 PHE A 142	None	0.99A	3g4lD-3nr5A: undetectable	3g4lD-3nr5A: 16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OCT_A_1N1A663_2 (TYROSINE-PROTEIN KINASE BTK)	3nr5	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG (Homo sapiens)	4 / 5	PHE A 154 ILE A 151 ASN A 105 PHE A 142	None	1.33A	3octA-3nr5A: undetectable	3octA-3nr5A: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_C_377C402_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3nr5	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG (Homo sapiens)	4 / 5	ASN A 54 GLU A 70 TYR A 121 PHE A 71	None	1.48A	4twdC-3nr5A: 0.0 4twdD-3nr5A: 0.0	4twdC-3nr5A: 18.21 4twdD-3nr5A: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3nr5	REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG (Homo sapiens)	4 / 6	ASN A 54 GLU A 70 TYR A 121 PHE A 71	None	1.46A	4twdG-3nr5A: undetectable 4twdH-3nr5A: undetectable	4twdG-3nr5A: 18.21 4twdH-3nr5A: 18.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E73_M_ASCM995_0","MYROSINASE MA1","3nr5","REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG","Homo sapiens",4,"ILE A  50;TYR A 121;PHE A 142;PHE A 130","None","1.21A","1e73M-3nr5A:undetectable","1e73M-3nr5A:15.77"],["3G4L_D_ROFD904_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","3nr5","REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG","Homo sapiens",3,"ASN A 140;MET A   1;PHE A 142","None","0.99A","3g4lD-3nr5A:undetectable","3g4lD-3nr5A:16.58"],["3OCT_A_1N1A663_2","TYROSINE-PROTEIN KINASE BTK","3nr5","REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG","Homo sapiens",4,"PHE A 154;ILE A 151;ASN A 105;PHE A 142","None","1.33A","3octA-3nr5A:undetectable","3octA-3nr5A:19.77"],["4TWD_C_377C402_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3nr5","REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG","Homo sapiens",4,"ASN A  54;GLU A  70;TYR A 121;PHE A  71","None","1.48A","4twdC-3nr5A:0.0;4twdD-3nr5A:0.0","4twdC-3nr5A:18.21;4twdD-3nr5A:18.21"],["4TWD_H_377H401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3nr5","REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG","Homo sapiens",4,"ASN A  54;GLU A  70;TYR A 121;PHE A  71","None","1.46A","4twdG-3nr5A:undetectable;4twdH-3nr5A:undetectable","4twdG-3nr5A:18.21;4twdH-3nr5A:18.21"]]