SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 8 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfA-3nr8B:
undetectable		 1gsfA-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 8 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfB-3nr8B:
undetectable		 1gsfB-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 8 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfC-3nr8B:
undetectable		 1gsfC-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 8 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfD-3nr8B:
undetectable		 1gsfD-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 7 GLY B 542
HIS B 561
THR B 532
ILE B 579
 None
 0.97A 1gtnF-3nr8B:
undetectable
1gtnG-3nr8B:
undetectable		 1gtnF-3nr8B:
12.30
1gtnG-3nr8B:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 PHE B 603
PHE B 557
PHE B 548
VAL B 727
 None
 1.07A 2lh6A-3nr8B:
undetectable		 2lh6A-3nr8B:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		3 / 3 PHE B 657
CYH B 709
PHE B 722
 None
 1.08A 3cr5X-3nr8B:
undetectable		 3cr5X-3nr8B:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		5 / 12 LEU B 585
ALA B 543
GLY B 545
SER B 528
TRP B 604
 None
 1.36A 3ou6D-3nr8B:
undetectable		 3ou6D-3nr8B:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 LEU B 489
GLY B 488
PHE B 446
PHE B 469
 None
 1.19A 3smtA-3nr8B:
undetectable		 3smtA-3nr8B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		5 / 10 PHE B 555
PHE B 603
VAL B 468
PHE B 557
ILE B 522
 None
 1.38A 3t3qA-3nr8B:
undetectable		 3t3qA-3nr8B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		5 / 10 PHE B 555
PHE B 603
VAL B 468
PHE B 557
ILE B 522
 None
 1.34A 3t3qB-3nr8B:
undetectable		 3t3qB-3nr8B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		5 / 10 PHE B 555
PHE B 603
VAL B 468
PHE B 557
ILE B 522
 None
 1.36A 3t3qC-3nr8B:
undetectable		 3t3qC-3nr8B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		5 / 10 PHE B 555
PHE B 603
VAL B 468
PHE B 557
ILE B 522
 None
 1.36A 3t3qD-3nr8B:
undetectable		 3t3qD-3nr8B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 HIS B 718
SER B 716
SER B 435
VAL B 436
 None
 1.32A 4a99D-3nr8B:
undetectable		 4a99D-3nr8B:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 8 THR B 430
ASP B 478
VAL B 546
GLY B 545
 None
 0.80A 5nzyA-3nr8B:
undetectable		 5nzyA-3nr8B:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.32A 5vooA-3nr8B:
undetectable		 5vooA-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.30A 5vooB-3nr8B:
undetectable		 5vooB-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.32A 5vooC-3nr8B:
undetectable		 5vooC-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.32A 5vooD-3nr8B:
undetectable		 5vooD-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.34A 5vooE-3nr8B:
undetectable		 5vooE-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 4 ASP B 607
ASN B 432
ASP B 717
ASN B 684
 None
 1.31A 5vooF-3nr8B:
undetectable		 5vooF-3nr8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 5 GLY B 545
GLN B 503
VAL B 530
SER B 584
 None
 1.19A 5vunA-3nr8B:
undetectable		 5vunA-3nr8B:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens) 		4 / 7 ASN B 432
HIS B 718
GLY B 565
ASN B 609
 None
 0.97A 5x7pA-3nr8B:
undetectable		 5x7pA-3nr8B:
13.36