SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ASN A 186
SER A 185
ASP A 134
ALA A 207
ILE A 203
 None
LLP  A 252 ( 4.5A)
None
None
None
 1.35A 1s14B-3nraA:
undetectable		 1s14B-3nraA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 TYR A 338
PHE A 371
THR A 366
GLU A 370
 None
 1.46A 2dttB-3nraA:
undetectable
2dttC-3nraA:
undetectable		 2dttB-3nraA:
15.10
2dttC-3nraA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 7 VAL A 244
ARG A 234
HIS A 232
THR A  94
 None
 1.10A 2f78A-3nraA:
0.8		 2f78A-3nraA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 9 THR A 107
GLY A 262
THR A 110
ALA A 113
LEU A 116
 None
None
LLP  A 252 ( 4.2A)
None
None
 1.25A 2npnA-3nraA:
undetectable		 2npnA-3nraA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 10 TYR A 195
ILE A 200
PHE A 182
LEU A 168
LEU A 171
 None
 1.50A 2w98A-3nraA:
2.7		 2w98A-3nraA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 249
GLY A 262
GLY A 109
GLY A 112
 None
None
LLP  A 252 ( 3.5A)
None
 0.45A 3bogA-3nraA:
undetectable
3bogC-3nraA:
undetectable		 3bogA-3nraA:
undetectable
3bogC-3nraA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 GLY A 109
GLY A 249
GLY A 262
 LLP  A 252 ( 3.5A)
None
None
 0.41A 3bogD-3nraA:
undetectable		 3bogD-3nraA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 356
GLN A 360
ALA A 361
LEU A 357
LEU A 346
 None
 1.15A 3ozwB-3nraA:
undetectable		 3ozwB-3nraA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 339
LEU A 223
TYR A 220
ALA A 228
TYR A 225
 None
None
LLP  A 252 ( 3.7A)
GOL  A 519 (-3.3A)
None
 1.05A 3vw7A-3nraA:
undetectable		 3vw7A-3nraA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.02A 4j6cA-3nraA:
undetectable		 4j6cA-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 10 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.05A 4j6cB-3nraA:
undetectable		 4j6cB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.00A 4j6dA-3nraA:
undetectable		 4j6dA-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.04A 4j6dB-3nraA:
undetectable		 4j6dB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.00A 4jbtA-3nraA:
undetectable		 4jbtA-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 GLN A 385
ALA A 393
ALA A 394
VAL A 401
LEU A 343
 None
 1.00A 4jbtB-3nraA:
undetectable		 4jbtB-3nraA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 THR A 231
LEU A 168
GLN A 153
LEU A 154
 None
 1.25A 4nc3A-3nraA:
undetectable		 4nc3A-3nraA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 SER A 282
GLY A 262
GLY A 109
LEU A 256
ILE A 106
 None
None
LLP  A 252 ( 3.5A)
None
None
 1.06A 4pghA-3nraA:
3.0		 4pghA-3nraA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 SER A 282
GLY A 262
GLY A 109
LEU A 256
ILE A 106
 None
None
LLP  A 252 ( 3.5A)
None
None
 1.08A 4pghD-3nraA:
undetectable		 4pghD-3nraA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 LEU A 318
VAL A 363
VAL A 379
ARG A  32
 None
 0.95A 4r7iA-3nraA:
undetectable		 4r7iA-3nraA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 112
ALA A 113
GLY A 109
PRO A 108
 None
None
LLP  A 252 ( 3.5A)
None
 0.95A 4u9uA-3nraA:
undetectable		 4u9uA-3nraA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 7 ASN A 189
PRO A 190
PHE A 340
PHE A 383
 LLP  A 252 (-4.0A)
None
None
None
 1.32A 4v32A-3nraA:
undetectable		 4v32A-3nraA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 ALA A 119
THR A 121
VAL A 245
ILE A 270
 None
 0.94A 4xe3A-3nraA:
undetectable		 4xe3A-3nraA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 270
SER A 267
GLY A 266
GLU A 242
THR A 121
 None
 1.08A 4xt8A-3nraA:
undetectable		 4xt8A-3nraA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 4 VAL A 214
ALA A 216
ASN A 186
GLN A 218
 None
 1.45A 4zgfA-3nraA:
undetectable		 4zgfA-3nraA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 ILE A 247
GLY A 109
LEU A 293
LEU A  86
 None
LLP  A 252 ( 3.5A)
None
None
 0.85A 5hs1A-3nraA:
undetectable		 5hs1A-3nraA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 179
PHE A   7
ILE A   3
PHE A 144
THR A 121
 None
 1.27A 5jlcA-3nraA:
undetectable		 5jlcA-3nraA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 113
LEU A 116
ALA A 117
THR A 121
THR A 246
 None
 0.93A 5k9dA-3nraA:
undetectable		 5k9dA-3nraA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 10 GLY A 112
GLY A 109
ILE A 215
LEU A 116
ALA A 117
 None
LLP  A 252 ( 3.5A)
None
None
None
 1.03A 5l0zB-3nraA:
undetectable		 5l0zB-3nraA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 LEU A 114
THR A 121
VAL A 128
VAL A 181
 None
 0.99A 6cp4A-3nraA:
undetectable		 6cp4A-3nraA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 TYR A 195
ALA A 191
LEU A 154
 None
 0.74A 6d9kF-3nraA:
2.0		 6d9kF-3nraA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 104
GLN A 278
GLY A 112
LEU A  86
GLN A 290
 None
 1.45A 6euqA-3nraA:
undetectable		 6euqA-3nraA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 THR A 246
PHE A 265
ILE A 106
VAL A 263
MET A 248
 None
 1.48A 6hcoA-3nraA:
undetectable
6hcoB-3nraA:
0.4		 6hcoA-3nraA:
20.83
6hcoB-3nraA:
20.83