SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		3 / 3 TRP A  79
VAL A   8
TRP A  80
 None
EDO  A 290 ( 4.6A)
None
 1.30A 1gmkC-3nrbA:
undetectable
1gmkD-3nrbA:
undetectable		 1gmkC-3nrbA:
5.92
1gmkD-3nrbA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		5 / 11 ALA A 165
ARG A 188
VAL A 266
LEU A 101
ALA A 171
 None
 1.08A 1n4hA-3nrbA:
undetectable		 1n4hA-3nrbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		3 / 3 ASP A 180
LEU A 181
PHE A 184
 None
 0.68A 4pthA-3nrbA:
undetectable		 4pthA-3nrbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 ILE A 190
LEU A 177
GLY A 187
PHE A 223
ILE A 168
 None
 1.09A 5j7wC-3nrbA:
undetectable		 5j7wC-3nrbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		4 / 7 LEU A 267
VAL A   8
GLU A  36
SER A  53
 None
EDO  A 290 ( 4.6A)
None
None
 1.32A 5umwA-3nrbA:
undetectable
5umwF-3nrbA:
undetectable		 5umwA-3nrbA:
13.12
5umwF-3nrbA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		4 / 5 LEU A 104
TYR A 106
LEU A 113
GLU A 112
 None
UNL  A 288 ( 4.4A)
None
None
 1.35A 5weaA-3nrbA:
3.0		 5weaA-3nrbA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 ILE A 190
LEU A 177
GLY A 187
PHE A 223
ILE A 168
 None
 1.10A 6qyaB-3nrbA:
undetectable		 6qyaB-3nrbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Pseudomonas
putida) 		5 / 12 ILE A 190
LEU A 177
GLY A 187
PHE A 223
ILE A 168
 None
 1.09A 6qyaD-3nrbA:
undetectable		 6qyaD-3nrbA:
20.49