SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		4 / 5 PRO A  40
ILE A  45
ARG A  42
ASP A  55
 None
 1.49A 2rhmB-3nrdA:
undetectable		 2rhmB-3nrdA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		4 / 7 GLU A  50
ILE A  45
PHE A  49
HIS A  94
 None
None
None
SO4  A 207 (-3.9A)
 1.10A 4a97A-3nrdA:
undetectable		 4a97A-3nrdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		4 / 6 GLU A  50
ILE A  45
PHE A  49
HIS A  94
 None
None
None
SO4  A 207 (-3.9A)
 1.20A 4a97I-3nrdA:
undetectable		 4a97I-3nrdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		5 / 11 ILE A 130
ALA A 127
GLU A 122
GLY A  14
ASN A  29
 None
None
GOL  A 201 (-3.7A)
None
None
 1.50A 4j83A-3nrdA:
undetectable		 4j83A-3nrdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		5 / 10 HIS A  94
LEU A  10
ASP A  13
VAL A  88
GLY A  85
 SO4  A 207 (-3.9A)
GOL  A 203 (-4.6A)
GOL  A 203 (-3.2A)
GOL  A 203 ( 4.4A)
SO4  A 207 (-3.2A)
 1.47A 5zbdB-3nrdA:
undetectable		 5zbdB-3nrdA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 3nrd HISTIDINE TRIAD
(HIT) PROTEIN
(Sinorhizobium
meliloti) 		4 / 4 GLU A  77
ASP A 102
ARG A  98
TRP A 105
 None
 1.44A 6mn8A-3nrdA:
0.0		 6mn8A-3nrdA:
13.77