SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3nrk LIC12922
(Leptospira
interrogans) 		5 / 12 GLY A 165
ILE A 172
LEU A 168
ALA A 108
VAL A 104
 None
 0.95A 1jg2A-3nrkA:
undetectable		 1jg2A-3nrkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3nrk LIC12922
(Leptospira
interrogans) 		4 / 5 ALA A  55
TYR A 346
ILE A  54
ASP A  96
 None
 1.08A 1upfA-3nrkA:
undetectable		 1upfA-3nrkA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3nrk LIC12922
(Leptospira
interrogans) 		4 / 5 ALA A  55
TYR A 346
ILE A  54
ASP A  96
 None
 1.07A 1upfC-3nrkA:
undetectable		 1upfC-3nrkA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3nrk LIC12922
(Leptospira
interrogans) 		4 / 8 ILE A 197
PHE A 235
GLY A 280
GLY A 281
 None
 0.82A 2qx4A-3nrkA:
undetectable
2qx4B-3nrkA:
undetectable		 2qx4A-3nrkA:
19.88
2qx4B-3nrkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3nrk LIC12922
(Leptospira
interrogans) 		3 / 3 GLU A 322
GLN A 161
ARG A 127
 None
 0.86A 2w3bB-3nrkA:
undetectable		 2w3bB-3nrkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3nrk LIC12922
(Leptospira
interrogans) 		3 / 3 ARG A 200
LYS A 297
GLU A 299
 None
 0.67A 5d0yA-3nrkA:
undetectable		 5d0yA-3nrkA:
18.58