SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 0.78A 1gtiA-3nrnA:
undetectable		 1gtiA-3nrnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 0.79A 1gtiB-3nrnA:
undetectable		 1gtiB-3nrnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 1.04A 1gtiD-3nrnA:
undetectable		 1gtiD-3nrnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 0.75A 1gtiE-3nrnA:
undetectable		 1gtiE-3nrnA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 8 PRO A 181
PRO A  83
GLY A  85
LEU A 183
 None
 0.84A 1h4oG-3nrnA:
undetectable		 1h4oG-3nrnA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 LEU A  49
LEU A  54
TYR A 352
GLN A 350
 None
 0.79A 1kt3A-3nrnA:
undetectable		 1kt3A-3nrnA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 GLY A   7
ALA A   8
GLY A  16
ILE A  26
ILE A  35
 AMP  A 422 (-3.2A)
AMP  A 422 ( 4.7A)
None
None
None
 0.87A 1sdtB-3nrnA:
undetectable		 1sdtB-3nrnA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 ILE A 340
VAL A 276
ALA A 275
MET A 316
PHE A 297
 None
 1.15A 1udtA-3nrnA:
undetectable		 1udtA-3nrnA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 GLY A  60
GLY A  63
LEU A 183
GLU A  61
ILE A 286
 None
 0.81A 2oxtB-3nrnA:
3.6		 2oxtB-3nrnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 7 PRO A 181
PRO A  83
GLY A  85
LEU A 183
 None
 0.80A 2vl2B-3nrnA:
undetectable		 2vl2B-3nrnA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 ILE A 294
GLY A 296
PHE A 297
PHE A 341
ILE A 340
 None
 1.31A 2y7kC-3nrnA:
undetectable		 2y7kC-3nrnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 10 THR A 289
ILE A 294
GLY A 296
PHE A 341
ILE A 340
 None
 1.45A 2y7pA-3nrnA:
undetectable		 2y7pA-3nrnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 9 GLY A 311
GLY A 278
ILE A 315
LEU A 314
ALA A 308
 None
 0.99A 2z0yA-3nrnA:
undetectable		 2z0yA-3nrnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 GLY A   7
ALA A   8
GLY A  16
ILE A  26
ILE A  35
 AMP  A 422 (-3.2A)
AMP  A 422 ( 4.7A)
None
None
None
 1.03A 3d20A-3nrnA:
undetectable		 3d20A-3nrnA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 GLY A   7
ALA A   8
GLY A  16
ILE A  26
ILE A  35
 AMP  A 422 (-3.2A)
AMP  A 422 ( 4.7A)
None
None
None
 0.96A 3nduB-3nrnA:
undetectable		 3nduB-3nrnA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 9 ALA A   8
ILE A 192
GLY A  16
ILE A  26
ILE A  35
 AMP  A 422 ( 4.7A)
None
None
None
None
 1.10A 3nu4A-3nrnA:
undetectable		 3nu4A-3nrnA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 GLY A   7
ALA A   8
GLY A  16
ILE A  26
ILE A  35
 AMP  A 422 (-3.2A)
AMP  A 422 ( 4.7A)
None
None
None
 0.99A 3tkgC-3nrnA:
undetectable		 3tkgC-3nrnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 6 LEU A  69
LEU A  10
MET A 397
VAL A 377
 None
 1.16A 4okbA-3nrnA:
undetectable		 4okbA-3nrnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 12 VAL A 396
GLY A  12
ALA A  15
LEU A  72
LEU A  68
 None
 1.06A 5xxiA-3nrnA:
undetectable		 5xxiA-3nrnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		4 / 8 LEU A  29
VAL A   6
VAL A   4
PHE A 232
 None
AMP  A 422 ( 4.7A)
None
None
 0.79A 5y9mA-3nrnA:
undetectable		 5y9mA-3nrnA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 10 LEU A  10
VAL A 191
ALA A  74
ALA A  17
LEU A  68
 None
 1.38A 6h1lA-3nrnA:
undetectable		 6h1lA-3nrnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3nrn UNCHARACTERIZED
PROTEIN PF1083
(Pyrococcus
furiosus) 		5 / 11 GLY A 406
LEU A  19
ALA A  15
PHE A 408
ALA A 399
 None
 1.42A 6qgbA-3nrnA:
undetectable		 6qgbA-3nrnA:
20.07