SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ns1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 10 GLU B 416
LEU B 441
GLU B 451
ALA B 453
GLY B 437
 None
 1.41A 1cmcA-3ns1B:
undetectable
1cmcB-3ns1B:
undetectable		 1cmcA-3ns1B:
16.16
1cmcB-3ns1B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 1jffB-3ns1B:
undetectable		 1jffB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		3 / 3 ALA B 282
VAL B 258
TRP B 236
 None
FAD  B 606 (-3.6A)
None
 0.90A 1nt5A-3ns1B:
undetectable		 1nt5A-3ns1B:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		3 / 3 ALA B 282
VAL B 258
TRP B 236
 None
FAD  B 606 (-3.6A)
None
 0.90A 1nt5B-3ns1B:
undetectable		 1nt5B-3ns1B:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 8 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.02A 2bfpA-3ns1B:
undetectable		 2bfpA-3ns1B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 8 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.00A 2bfpC-3ns1B:
undetectable		 2bfpC-3ns1B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 8 SER B 368
PHE B 365
LEU B 348
LEU B 334
 None
 1.00A 2bfpD-3ns1B:
undetectable		 2bfpD-3ns1B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 2hxfB-3ns1B:
undetectable		 2hxfB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 2hxhB-3ns1B:
undetectable		 2hxhB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 2p4nB-3ns1B:
undetectable		 2p4nB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 2wbeB-3ns1B:
undetectable		 2wbeB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 5 LEU B 454
GLN B 473
THR B 470
LEU B 513
 None
 1.13A 3ce6D-3ns1B:
undetectable		 3ce6D-3ns1B:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 3dcoB-3ns1B:
undetectable		 3dcoB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.20A 3edlB-3ns1B:
undetectable		 3edlB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		6 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
None
 1.19A 3iz0B-3ns1B:
undetectable		 3iz0B-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
 1.30A 3j6pB-3ns1B:
undetectable		 3j6pB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 10 LEU B 312
VAL B 330
ILE B 407
LEU B 348
PHE B 365
 None
 1.04A 3jw5B-3ns1B:
undetectable		 3jw5B-3ns1B:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 9 ILE B 407
LEU B 372
LYS B 256
ILE B 403
LYS B 395
 None
None
FAD  B 606 (-3.9A)
FAD  B 606 ( 4.1A)
None
 1.28A 3sj4X-3ns1B:
undetectable		 3sj4X-3ns1B:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 7 TYR B 393
ALA B 460
GLY B 458
GLY B 502
 None
 0.83A 5e26A-3ns1B:
undetectable
5e26B-3ns1B:
undetectable		 5e26A-3ns1B:
23.44
5e26B-3ns1B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 7 GLY B 458
GLY B 502
TYR B 393
ALA B 460
 None
 0.84A 5e26C-3ns1B:
undetectable
5e26D-3ns1B:
undetectable		 5e26C-3ns1B:
23.44
5e26D-3ns1B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
 None
FAD  B 606 (-4.8A)
None
None
None
 0.97A 5hnwB-3ns1B:
undetectable		 5hnwB-3ns1B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
PRO B 410
 None
FAD  B 606 (-4.8A)
None
None
None
 1.04A 5hnyB-3ns1B:
undetectable		 5hnyB-3ns1B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 VAL B 330
LEU B 404
THR B 373
PRO B 410
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
 1.24A 5ogcB-3ns1B:
undetectable		 5ogcB-3ns1B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 TYR B 411
PHE B 327
ILE B 297
LEU B 312
HIS B 292
 None
 1.33A 5zwrB-3ns1B:
undetectable		 5zwrB-3ns1B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 VAL B 330
LEU B 404
LEU B 372
THR B 373
GLY B 296
 None
FAD  B 606 (-4.8A)
None
None
None
 0.91A 6b0cD-3ns1B:
undetectable		 6b0cD-3ns1B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 11 ILE B 278
THR B 354
THR B 262
ASN B 261
MET B 268
 None
FAD  B 606 (-4.5A)
FAD  B 606 (-2.9A)
None
None
 1.35A 6hupA-3ns1B:
undetectable
6hupB-3ns1B:
undetectable		 6hupA-3ns1B:
15.33
6hupB-3ns1B:
11.94