SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ns4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1URM_A_BEZA201_0 (PEROXIREDOXIN 5)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	5 / 9	PRO A 600 GLY A 711 LEU A 762 PHE A 758 ARG A 611	None	1.18A	1urmA-3ns4A: undetectable	1urmA-3ns4A: 18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1003_0 (ALDEHYDE DEHYDROGENASE A)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	4 / 5	ILE A 666 LEU A 669 ASP A 584 ALA A 662	None	0.95A	2opxA-3ns4A: undetectable	2opxA-3ns4A: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V81_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	4 / 8	LEU A 680 VAL A 619 LEU A 707 TYR A 686	None	0.97A	3v81A-3ns4A: undetectable	3v81A-3ns4A: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V81_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	4 / 8	LEU A 680 VAL A 619 LEU A 707 TYR A 686	None	1.02A	3v81C-3ns4A: undetectable	3v81C-3ns4A: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYS_A_ACTA402_0 (MCCC FAMILY PROTEIN)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	4 / 6	SER A 700 ASP A 699 ARG A 743 GLU A 759	None	1.17A	4eysA-3ns4A: undetectable	4eysA-3ns4A: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWD_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	4 / 8	LEU A 680 VAL A 619 LEU A 707 TYR A 686	None	0.95A	4pwdC-3ns4A: undetectable	4pwdC-3ns4A: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JO9_A_SORA302_0 (RIBITOL 2-DEHYDROGENASE)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	5 / 12	LEU A 709 PRO A 600 VAL A 601 TRP A 714 PHE A 758	None	1.18A	5jo9A-3ns4A: undetectable	5jo9A-3ns4A: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JO9_A_SORA302_0 (RIBITOL 2-DEHYDROGENASE)	3ns4	VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 (Saccharomyces cerevisiae)	5 / 12	LEU A 709 TRP A 719 PRO A 600 VAL A 601 PHE A 758	None	1.26A	5jo9A-3ns4A: undetectable	5jo9A-3ns4A: 20.49

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1URM_A_BEZA201_0","PEROXIREDOXIN 5","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",5,"PRO A 600;GLY A 711;LEU A 762;PHE A 758;ARG A 611","None","1.18A","1urmA-3ns4A:undetectable","1urmA-3ns4A:18.01"],["2OPX_A_DXCA1003_0","ALDEHYDE DEHYDROGENASE A","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",4,"ILE A 666;LEU A 669;ASP A 584;ALA A 662","None","0.95A","2opxA-3ns4A:undetectable","2opxA-3ns4A:18.96"],["3V81_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",4,"LEU A 680;VAL A 619;LEU A 707;TYR A 686","None","0.97A","3v81A-3ns4A:undetectable","3v81A-3ns4A:17.72"],["3V81_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",4,"LEU A 680;VAL A 619;LEU A 707;TYR A 686","None","1.02A","3v81C-3ns4A:undetectable","3v81C-3ns4A:17.72"],["4EYS_A_ACTA402_0","MCCC FAMILY PROTEIN","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",4,"SER A 700;ASP A 699;ARG A 743;GLU A 759","None","1.17A","4eysA-3ns4A:undetectable","4eysA-3ns4A:22.01"],["4PWD_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",4,"LEU A 680;VAL A 619;LEU A 707;TYR A 686","None","0.95A","4pwdC-3ns4A:undetectable","4pwdC-3ns4A:17.72"],["5JO9_A_SORA302_0","RIBITOL 2-DEHYDROGENASE","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",5,"LEU A 709;PRO A 600;VAL A 601;TRP A 714;PHE A 758","None","1.18A","5jo9A-3ns4A:undetectable","5jo9A-3ns4A:20.49"],["5JO9_A_SORA302_0","RIBITOL 2-DEHYDROGENASE","3ns4","VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53","Saccharomyces cerevisiae",5,"LEU A 709;TRP A 719;PRO A 600;VAL A 601;PHE A 758","None","1.26A","5jo9A-3ns4A:undetectable","5jo9A-3ns4A:20.49"]]