SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ns5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XN3_A_ID8A1356_1 (THYROXINE-BINDING GLOBULIN)	3ns5	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B (Saccharomyces cerevisiae)	4 / 8	LEU A 155 LEU A 95 LYS A 96 LEU A 102	None	0.89A	2xn3A-3ns5A: undetectable 2xn3B-3ns5A: undetectable	2xn3A-3ns5A: 18.15 2xn3B-3ns5A: 28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XN5_A_FUNA1356_1 (THYROXINE-BINDING GLOBULIN)	3ns5	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B (Saccharomyces cerevisiae)	5 / 11	LEU A 155 LEU A 149 LEU A 95 LYS A 96 LEU A 102	None	1.06A	2xn5A-3ns5A: undetectable	2xn5A-3ns5A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZT_A_RTLA201_1 (RETINOL-BINDING PROTEIN 2)	3ns5	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B (Saccharomyces cerevisiae)	3 / 3	PHE A 103 THR A 123 LEU A 149	None	0.78A	4qztA-3ns5A: undetectable	4qztA-3ns5A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YW0_A_ACTA412_0 (UNCHARACTERIZED PROTEIN KDOO)	3ns5	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B (Saccharomyces cerevisiae)	3 / 3	LYS A 139 ASN A 135 SER A 133	None	1.15A	5yw0A-3ns5A: undetectable	5yw0A-3ns5A: 16.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XN3_A_ID8A1356_1","THYROXINE-BINDING GLOBULIN;THYROXINE-BINDING GLOBULIN","3ns5","EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B","Saccharomyces cerevisiae",4,"LEU A 155;LEU A  95;LYS A  96;LEU A 102","None","0.89A","2xn3A-3ns5A:undetectable;2xn3B-3ns5A:undetectable","2xn3A-3ns5A:18.15;2xn3B-3ns5A:28.00"],["2XN5_A_FUNA1356_1","THYROXINE-BINDING GLOBULIN","3ns5","EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B","Saccharomyces cerevisiae",5,"LEU A 155;LEU A 149;LEU A  95;LYS A  96;LEU A 102","None","1.06A","2xn5A-3ns5A:undetectable","2xn5A-3ns5A:18.15"],["4QZT_A_RTLA201_1","RETINOL-BINDING PROTEIN 2","3ns5","EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B","Saccharomyces cerevisiae",3,"PHE A 103;THR A 123;LEU A 149","None","0.78A","4qztA-3ns5A:undetectable","4qztA-3ns5A:21.54"],["5YW0_A_ACTA412_0","UNCHARACTERIZED PROTEIN KDOO","3ns5","EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B","Saccharomyces cerevisiae",3,"LYS A 139;ASN A 135;SER A 133","None","1.15A","5yw0A-3ns5A:undetectable","5yw0A-3ns5A:16.67"]]