SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 4 ALA A 117
VAL A 116
ALA A 154
HIS A 150
 None
 1.25A 1q23F-3nsjA:
undetectable		 1q23F-3nsjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 11 LEU A 426
LEU A 493
VAL A 452
GLY A 450
ARG A 448
 None
None
GOL  A 653 (-4.3A)
GOL  A 653 (-3.5A)
GOL  A 652 (-3.8A)
 1.46A 1y4lB-3nsjA:
undetectable		 1y4lB-3nsjA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 12 GLY A  56
TYR A 218
LEU A 214
GLU A 213
TYR A 366
 None
 1.47A 2vqyA-3nsjA:
undetectable		 2vqyA-3nsjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 12 TYR A 366
GLY A 148
VAL A 116
ARG A 370
SER A 151
 None
 1.19A 3dlcA-3nsjA:
undetectable		 3dlcA-3nsjA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 4 PRO A  59
TYR A 218
GLY A 219
THR A 220
 None
 1.21A 3ib0A-3nsjA:
undetectable		 3ib0A-3nsjA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 7 HIS A  93
GLU A 343
ARG A 181
PRO A 186
 None
 1.11A 3ql6A-3nsjA:
undetectable		 3ql6A-3nsjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 4 ASP A 227
ASP A 339
GLY A 230
THR A 172
 None
 1.34A 3tl9B-3nsjA:
undetectable		 3tl9B-3nsjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 9 LEU A 257
LEU A 238
PHE A 315
GLU A 297
VAL A 234
 None
 1.49A 3tmzA-3nsjA:
undetectable		 3tmzA-3nsjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 7 ALA A 106
SER A 170
THR A 172
SER A 233
 None
 0.52A 4ikjA-3nsjA:
3.3
4ikjB-3nsjA:
undetectable		 4ikjA-3nsjA:
14.56
4ikjB-3nsjA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 7 SER A 233
ALA A 106
SER A 170
THR A 172
 None
 0.68A 4ikkA-3nsjA:
undetectable
4ikkB-3nsjA:
3.2		 4ikkA-3nsjA:
14.56
4ikkB-3nsjA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 SER A 170
ALA A 108
PHE A 168
GLU A 119
 None
 0.90A 4m93B-3nsjA:
undetectable
4m93C-3nsjA:
undetectable		 4m93B-3nsjA:
17.86
4m93C-3nsjA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3nsj PERFORIN-1
(Mus
musculus) 		3 / 3 VAL A 481
PHE A 518
ARG A 498
 None
None
CL  A 720 (-3.9A)
 0.94A 4xr4B-3nsjA:
undetectable		 4xr4B-3nsjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		3 / 3 THR A 449
HIS A 505
LEU A 477
 GOL  A 653 (-4.6A)
None
None
 0.83A 5axdA-3nsjA:
undetectable		 5axdA-3nsjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 9 VAL A 134
ILE A 367
VAL A  49
LEU A  52
ARG A 129
 None
 1.41A 5fxfA-3nsjA:
0.7		 5fxfA-3nsjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8A-3nsjA:
undetectable		 5hm8A-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8B-3nsjA:
undetectable		 5hm8B-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8C-3nsjA:
undetectable		 5hm8C-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8D-3nsjA:
undetectable		 5hm8D-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8E-3nsjA:
undetectable		 5hm8E-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8F-3nsjA:
undetectable		 5hm8F-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8G-3nsjA:
undetectable		 5hm8G-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 GLU A 174
THR A 172
GLU A 119
LEU A  52
 None
 1.25A 5hm8H-3nsjA:
undetectable		 5hm8H-3nsjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3nsj PERFORIN-1
(Mus
musculus) 		5 / 12 LEU A 493
GLY A 494
VAL A 481
ALA A 436
HIS A 513
 None
 0.59A 5xv7A-3nsjA:
undetectable		 5xv7A-3nsjA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 7 GLN A 410
GLY A 475
PHE A 442
GLY A 443
 IOD  A 712 (-4.4A)
None
None
None
 0.93A 6ekzA-3nsjA:
undetectable		 6ekzA-3nsjA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3nsj PERFORIN-1
(Mus
musculus) 		4 / 5 LEU A 534
THR A 532
THR A 529
GLY A 530
 None
 1.14A 6gtqA-3nsjA:
undetectable		 6gtqA-3nsjA:
15.96