SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 6 TRP A 127
GLY A 125
ASN A 102
PRO A 121
 None
 1.30A 1dedA-3nt8A:
undetectable		 1dedA-3nt8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		5 / 12 THR A 360
GLY A 391
GLY A 390
GLY A 305
HIS A 396
 None
 1.20A 1wg8A-3nt8A:
undetectable		 1wg8A-3nt8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		3 / 3 ARG A 351
GLY A 339
PRO A 340
 None
 0.68A 2hreD-3nt8A:
undetectable		 2hreD-3nt8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		5 / 9 ALA A 130
SER A 128
GLY A 125
SER A 150
ALA A 148
 None
 1.49A 2vh3A-3nt8A:
undetectable		 2vh3A-3nt8A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 6 SER A 116
TYR A 164
VAL A 173
ASP A  36
 None
 1.43A 2x45A-3nt8A:
undetectable		 2x45A-3nt8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 5 ASP A  34
ARG A  37
TRP A  74
ILE A  32
 None
 1.35A 3sanA-3nt8A:
undetectable		 3sanA-3nt8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_2
(NEURAMINIDASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 5 ASP A  34
ARG A  37
TRP A  74
ILE A  32
 None
 1.35A 3sanB-3nt8A:
undetectable		 3sanB-3nt8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 5 ASP A  34
ARG A  37
TRP A  74
ILE A  32
 None
 1.35A 4mwrA-3nt8A:
undetectable		 4mwrA-3nt8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		3 / 3 ARG A  37
TRP A  74
ILE A  32
 None
 1.09A 4mwxA-3nt8A:
undetectable		 4mwxA-3nt8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 7 TYR A 177
ILE A  86
HIS A  44
LEU A 123
 None
 1.23A 4xo7B-3nt8A:
undetectable		 4xo7B-3nt8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		4 / 8 ILE A 356
TRP A 349
ARG A 351
ASP A 259
 None
 1.16A 5vlmF-3nt8A:
undetectable		 5vlmF-3nt8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3nt8 ANCYLOSTOMA SECRETED
PROTEIN 1
(Necator
americanus) 		5 / 11 ALA A 325
TRP A 329
TYR A 276
LEU A 370
ALA A 322
 None
 1.48A 6dk1C-3nt8A:
undetectable		 6dk1C-3nt8A:
19.73