SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ntc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR L  36
GLN L  89
TYR L  94
PHE L  98
TRP H  33
TRP H 103
 None
None
EDO  H 220 (-4.9A)
None
EDO  H 220 ( 3.9A)
None
 0.75A 1h8sA-3ntcL:
21.3		 1h8sA-3ntcL:
41.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.12A 1usqA-3ntcH:
undetectable		 1usqA-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.84A 1usqB-3ntcH:
undetectable		 1usqB-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.84A 1usqC-3ntcH:
undetectable		 1usqC-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.85A 1usqD-3ntcH:
undetectable		 1usqD-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.84A 1usqE-3ntcH:
undetectable		 1usqE-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.11A 1usqF-3ntcH:
2.2		 1usqF-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.88A 2aojA-3ntcL:
undetectable		 2aojA-3ntcL:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jkjE-3ntcH:
undetectable		 2jkjE-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklA-3ntcH:
undetectable		 2jklA-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.15A 2jklC-3ntcH:
2.1		 2jklC-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklD-3ntcH:
undetectable		 2jklD-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklE-3ntcH:
undetectable		 2jklE-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklF-3ntcH:
undetectable		 2jklF-3ntcH:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 TRP H  36
MET H  80
MET H  69
LEU H  82
 None
 1.40A 2oz7A-3ntcH:
undetectable		 2oz7A-3ntcH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 5 ILE H  51
PRO H  52
TYR H  52
TYR H  56
 None
 1.25A 3d9lA-3ntcH:
undetectable
3d9lY-3ntcH:
undetectable		 3d9lA-3ntcH:
17.70
3d9lY-3ntcH:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.53A 3huoA-3ntcH:
undetectable		 3huoA-3ntcH:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 ILE L  83
SER L  12
SER L  14
 None
 0.48A 3iltH-3ntcL:
undetectable		 3iltH-3ntcL:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.70A 3keeB-3ntcL:
undetectable		 3keeB-3ntcL:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 PHE L  71
TYR L  92
LEU L  47
 None
 0.78A 3sueB-3ntcL:
undetectable		 3sueB-3ntcL:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 ASP L 170
THR L 172
TYR L 140
THR L 109
 None
 1.29A 5b6iB-3ntcL:
undetectable		 5b6iB-3ntcL:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		4 / 6 ASN H  76
ALA H  24
PRO H  52
TYR H  27
 EDO  H 222 (-2.7A)
None
None
None
 1.14A 5umd2-3ntcH:
undetectable
5umdF-3ntcH:
undetectable		 5umd2-3ntcH:
17.41
5umdF-3ntcH:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 TYR H 102
LEU L  46
ASP L  91
 None
None
EDO  H 220 ( 4.5A)
 0.61A 5zv2B-3ntcH:
undetectable		 5zv2B-3ntcH:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 3ntc FAB HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
 0.19A 6cjkB-3ntcH:
24.2		 6cjkB-3ntcH:
53.15