SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ntl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 12 GLY A  59
ALA A 104
ILE A 281
VAL A 112
ILE A 101
 None
 1.08A 1hsgB-3ntlA:
undetectable		 1hsgB-3ntlA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 5 TYR A 216
PRO A  21
LEU A  22
THR A 312
 None
None
IHP  A 550 (-3.7A)
None
 1.31A 1i2wA-3ntlA:
undetectable		 1i2wA-3ntlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 4 ALA A  97
VAL A 285
ALA A  87
HIS A 114
 None
 1.13A 1q23F-3ntlA:
undetectable		 1q23F-3ntlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 4 ALA A  97
VAL A 285
ALA A  87
HIS A 114
 None
 1.21A 1q23K-3ntlA:
undetectable		 1q23K-3ntlA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 12 GLY A  59
ALA A 104
ILE A 281
VAL A 112
ILE A 101
 None
 1.12A 1sduB-3ntlA:
undetectable		 1sduB-3ntlA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 5 PHE A 320
LEU A 295
PHE A 380
MET A 384
 None
 1.37A 1wrkB-3ntlA:
undetectable		 1wrkB-3ntlA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 7 ILE A 291
ARG A  15
TYR A 303
GLU A 310
 None
IHP  A 550 (-3.9A)
None
None
 1.01A 2qebA-3ntlA:
undetectable		 2qebA-3ntlA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 7 ILE A 291
ARG A  15
TYR A 303
GLU A 310
 None
IHP  A 550 (-3.9A)
None
None
 1.03A 2qebB-3ntlA:
undetectable		 2qebB-3ntlA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 10 MET A 384
TYR A  86
LEU A 263
VAL A 264
LEU A 294
 None
 1.33A 2w98A-3ntlA:
undetectable		 2w98A-3ntlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 10 PHE A 320
MET A 384
LEU A 263
VAL A 264
LEU A 294
 None
 1.46A 2w98A-3ntlA:
undetectable		 2w98A-3ntlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 TYR A 266
ASP A 122
HIS A 113
 None
 0.73A 3e23A-3ntlA:
undetectable		 3e23A-3ntlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 5 PRO A 200
SER A 198
LEU A 207
SER A 206
 None
 1.44A 3ijxH-3ntlA:
undetectable		 3ijxH-3ntlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 5 PRO A 200
SER A 198
LEU A 207
SER A 206
 None
 1.41A 3iluH-3ntlA:
undetectable		 3iluH-3ntlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 9 LEU A 263
PHE A 320
SER A 293
ILE A 318
THR A 282
 None
 1.08A 3tq8A-3ntlA:
undetectable		 3tq8A-3ntlA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 PHE A 125
TYR A  84
TYR A 266
 None
 0.88A 4ffwA-3ntlA:
undetectable		 4ffwA-3ntlA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 10 LEU A 263
PHE A 320
SER A 293
ILE A 318
THR A 282
 None
 1.11A 4g8zX-3ntlA:
undetectable		 4g8zX-3ntlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.96A 4k8cA-3ntlA:
undetectable		 4k8cA-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.95A 4kahA-3ntlA:
undetectable		 4kahA-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.96A 4kahB-3ntlA:
undetectable		 4kahB-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.94A 4kanA-3ntlA:
undetectable		 4kanA-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.96A 4kanB-3ntlA:
undetectable		 4kanB-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.97A 4kbeA-3ntlA:
undetectable		 4kbeA-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.96A 4lbgA-3ntlA:
undetectable		 4lbgA-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		3 / 3 SER A 206
TYR A 245
PRO A  21
 None
IHP  A 550 (-4.8A)
None
 0.94A 4lbgB-3ntlA:
undetectable		 4lbgB-3ntlA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 7 TYR A 245
LEU A  18
THR A  48
THR A 312
 IHP  A 550 (-4.8A)
None
None
None
 0.97A 4mbsA-3ntlA:
undetectable		 4mbsA-3ntlA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		5 / 10 TRP A  65
GLN A 330
PHE A 374
LEU A   7
LEU A  66
 None
 1.31A 5fhzC-3ntlA:
undetectable		 5fhzC-3ntlA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE
(Enterobacter
cloacae) 		4 / 7 ASN A  25
ASP A 209
ASP A 288
ASN A 205
 IHP  A 550 ( 4.4A)
IHP  A 550 (-3.6A)
IHP  A 550 (-2.4A)
IHP  A 550 ( 4.2A)
 1.11A 5x7pA-3ntlA:
undetectable		 5x7pA-3ntlA:
15.29