SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ntx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 7 ALA A 304
LEU A 334
SER A 296
THR A 301
 None
None
None
GOL  A 341 (-4.6A)
 1.00A 1dvxA-3ntxA:
undetectable		 1dvxA-3ntxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 THR A 115
GLY A  90
GLY A  12
ASP A 170
PHE A 150
 None
 1.18A 1wg8A-3ntxA:
undetectable		 1wg8A-3ntxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 0.99A 1wmqA-3ntxA:
undetectable		 1wmqA-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 1.01A 1wmqB-3ntxA:
undetectable		 1wmqB-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 1.00A 1wpuA-3ntxA:
undetectable		 1wpuA-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 1.00A 1wpuB-3ntxA:
undetectable		 1wpuB-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 0.97A 1wrqA-3ntxA:
undetectable		 1wrqA-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 ILE A 185
GLY A 184
ALA A 183
HIS A 186
 None
 0.98A 1wrqB-3ntxA:
undetectable		 1wrqB-3ntxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.90A 1ya4B-3ntxA:
undetectable		 1ya4B-3ntxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.99A 1ya4C-3ntxA:
undetectable		 1ya4C-3ntxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 ILE A 238
LEU A 239
ALA A 305
GLY A 297
SER A 296
 None
 1.00A 2a58A-3ntxA:
undetectable
2a58B-3ntxA:
undetectable		 2a58A-3ntxA:
21.54
2a58B-3ntxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 ILE A 238
LEU A 239
ALA A 305
GLY A 297
SER A 296
 None
 1.00A 2a58B-3ntxA:
undetectable
2a58C-3ntxA:
4.5		 2a58B-3ntxA:
21.54
2a58C-3ntxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 ILE A 238
LEU A 239
ALA A 305
GLY A 297
SER A 296
 None
 1.00A 2a58D-3ntxA:
4.4
2a58E-3ntxA:
4.5		 2a58D-3ntxA:
21.54
2a58E-3ntxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 9 ALA A  95
ALA A  98
SER A 102
PHE A 103
ALA A 304
 None
 1.23A 2vh3A-3ntxA:
undetectable		 2vh3A-3ntxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 LEU A 155
GLY A  90
SER A 117
VAL A  86
ILE A 114
 None
 1.00A 3adxB-3ntxA:
undetectable		 3adxB-3ntxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 VAL A 179
LEU A 180
ILE A 113
PHE A 172
THR A 161
 None
 1.28A 3bjwF-3ntxA:
undetectable		 3bjwF-3ntxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		3 / 3 VAL A 193
SER A 195
LEU A 180
 None
 0.64A 3n8xA-3ntxA:
undetectable		 3n8xA-3ntxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 7 TRP A  68
ILE A  71
ILE A  75
VAL A 112
 None
 0.61A 3r9vA-3ntxA:
undetectable
3r9vB-3ntxA:
undetectable		 3r9vA-3ntxA:
23.76
3r9vB-3ntxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 ALA A 135
LEU A  88
LEU A  31
LEU A  35
ILE A  51
 None
 1.13A 3uvvA-3ntxA:
undetectable		 3uvvA-3ntxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 LEU A 138
ILE A 113
LEU A 101
GLY A  84
ALA A   9
 None
 1.02A 3uwlB-3ntxA:
undetectable		 3uwlB-3ntxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 LEU A 132
ILE A  87
VAL A   8
PHE A  49
LEU A 108
 None
 1.26A 3w67D-3ntxA:
undetectable		 3w67D-3ntxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 7 LEU A 239
VAL A 278
TYR A 242
LEU A 289
 None
 1.03A 4b3qA-3ntxA:
undetectable		 4b3qA-3ntxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 MET A 104
LEU A 105
ILE A  71
LEU A 101
HIS A  70
 None
 1.23A 4j24D-3ntxA:
undetectable		 4j24D-3ntxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 8 ALA A 100
ASP A  74
ILE A  71
ASP A  67
ILE A  58
 None
 1.42A 4kttD-3ntxA:
undetectable		 4kttD-3ntxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 9 ARG A 189
VAL A 193
LEU A 138
ARG A 157
SER A 148
 None
 1.36A 4ubsA-3ntxA:
undetectable		 4ubsA-3ntxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 11 THR A 208
LEU A 312
PRO A  65
ALA A 100
GLU A 333
 None
 1.32A 5ewjA-3ntxA:
2.3
5ewjB-3ntxA:
3.4		 5ewjA-3ntxA:
22.22
5ewjB-3ntxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 THR A 208
LEU A 312
PRO A  65
ALA A 100
GLU A 333
 None
 1.27A 5ewjC-3ntxA:
2.4
5ewjD-3ntxA:
3.2		 5ewjC-3ntxA:
22.22
5ewjD-3ntxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 8 THR A 307
LEU A 309
ILE A 212
LEU A 313
 None
 0.96A 5g48A-3ntxA:
undetectable		 5g48A-3ntxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 5 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
 0.80A 5x7pA-3ntxA:
2.8		 5x7pA-3ntxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
 0.81A 5x7pB-3ntxA:
undetectable		 5x7pB-3ntxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 10 PHE A 150
SER A 148
ILE A   6
ALA A 139
LEU A 138
 None
 1.44A 5zjiA-3ntxA:
undetectable
5zjiJ-3ntxA:
undetectable		 5zjiA-3ntxA:
13.98
5zjiJ-3ntxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		5 / 12 SER A 222
TYR A 218
ILE A 217
LEU A 239
LEU A 230
 None
 1.31A 5zwrB-3ntxA:
undetectable		 5zwrB-3ntxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		3 / 3 SER A  60
SER A  61
ALA A 166
 None
 0.65A 6dwnC-3ntxA:
0.1		 6dwnC-3ntxA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3ntx CYTOPLASMIC
L-ASPARAGINASE I
(Yersinia
pestis) 		4 / 6 MET A  63
ALA A  72
LEU A 101
ALA A 100
 None
 1.06A 6fosB-3ntxA:
undetectable		 6fosB-3ntxA:
14.33