SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3num'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 209
LEU A 364
ILE A 342
GLY A 341
LEU A 267
 None
 0.91A 1eqhA-3numA:
undetectable		 1eqhA-3numA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 209
LEU A 364
ILE A 342
GLY A 341
LEU A 267
 None
 0.98A 1eqhB-3numA:
undetectable		 1eqhB-3numA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 5 LEU A 364
ILE A 360
ILE A 251
ALA A 252
 None
 0.72A 2i2zA-3numA:
undetectable		 2i2zA-3numA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 GLY A 206
GLY A 329
GLY A 326
THR A 217
ILE A 215
 None
 1.08A 2oxtA-3numA:
undetectable		 2oxtA-3numA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 4 THR A 293
VAL A 333
GLY A 329
THR A 217
 None
 0.88A 3cflA-3numA:
undetectable		 3cflA-3numA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 THR A 293
ASN A 343
ILE A 342
VAL A 339
ILE A 179
 None
 1.41A 4eb6B-3numA:
undetectable
4eb6C-3numA:
undetectable		 4eb6B-3numA:
18.78
4eb6C-3numA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 ILE A 296
LEU A 265
GLY A 341
ASN A 343
ILE A 340
 None
 1.01A 4o1eB-3numA:
undetectable		 4o1eB-3numA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 PHE A 363
ILE A 360
ALA A 328
SER A 205
ILE A 342
 None
 1.20A 5mlmA-3numA:
undetectable		 5mlmA-3numA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		4 / 6 PRO A 263
VAL A 230
TYR A 238
ASN A 234
 None
 0.90A 5pbeA-3numA:
undetectable		 5pbeA-3numA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3num SERINE PROTEASE
HTRA1
(Homo
sapiens) 		5 / 12 VAL A 230
ILE A 186
SER A 210
VAL A 216
ILE A 254
 None
 1.40A 6gsdA-3numA:
undetectable		 6gsdA-3numA:
15.36