SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 THR A 334
ILE A 140
CYH A 142
GLN A 174
PHE A 178
 None
 1.07A 2akeA-3nuzA:
undetectable		 2akeA-3nuzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 THR A 334
ILE A 140
CYH A 142
GLN A 174
PHE A 178
 None
 1.10A 2azxA-3nuzA:
undetectable		 2azxA-3nuzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 LEU A 153
GLY A 147
ASN A 149
ALA A 193
ALA A 192
 None
 0.96A 2bm9E-3nuzA:
2.4		 2bm9E-3nuzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 11 THR A 334
ILE A 140
CYH A 142
GLN A 174
PHE A 178
 None
 1.16A 2dr2A-3nuzA:
undetectable		 2dr2A-3nuzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 TYR A 387
SER A 256
GLU A 260
ASP A 279
VAL A 391
 None
 1.34A 3cb8A-3nuzA:
2.7		 3cb8A-3nuzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 GLU A 103
GLY A 152
ALA A 160
ASP A 189
ARG A 201
 None
 1.29A 3jzjA-3nuzA:
undetectable		 3jzjA-3nuzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 8 GLY A 336
ILE A 331
PHE A 178
PHE A 400
 None
 0.94A 3ko0B-3nuzA:
undetectable
3ko0J-3nuzA:
undetectable		 3ko0B-3nuzA:
14.12
3ko0J-3nuzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 8 LEU A 163
ALA A 193
SER A 197
ARG A 201
 None
 1.02A 3kp6A-3nuzA:
undetectable		 3kp6A-3nuzA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 8 ILE A 143
PRO A 261
SER A 146
GLY A 258
 None
 0.90A 3lslA-3nuzA:
undetectable
3lslD-3nuzA:
undetectable		 3lslA-3nuzA:
23.28
3lslD-3nuzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 8 ILE A 143
PRO A 261
SER A 146
GLY A 258
 None
 0.88A 3lslA-3nuzA:
undetectable
3lslD-3nuzA:
undetectable		 3lslA-3nuzA:
23.28
3lslD-3nuzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 5 ILE A 143
PRO A 261
SER A 146
GLY A 258
 None
 0.76A 3tkdB-3nuzA:
undetectable		 3tkdB-3nuzA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 5 ILE A 143
PRO A 261
SER A 146
GLY A 258
 None
 0.76A 3tkdA-3nuzA:
undetectable		 3tkdA-3nuzA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 VAL A 393
PHE A 388
GLY A 395
SER A 256
GLU A 335
 None
 1.38A 4bvaA-3nuzA:
undetectable		 4bvaA-3nuzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 7 SER A 402
GLY A 148
GLY A 152
GLU A 151
 None
 0.75A 4koeA-3nuzA:
undetectable
4koeB-3nuzA:
undetectable
4koeD-3nuzA:
3.0		 4koeA-3nuzA:
22.70
4koeB-3nuzA:
22.70
4koeD-3nuzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		3 / 3 ARG A 307
GLU A 200
TYR A 224
 None
 0.98A 4r29D-3nuzA:
undetectable		 4r29D-3nuzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 7 GLY A 148
GLY A 152
GLU A 151
SER A 402
 None
 0.81A 4z53A-3nuzA:
undetectable
4z53B-3nuzA:
2.0		 4z53A-3nuzA:
19.30
4z53B-3nuzA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 10 GLY A 258
GLY A 145
SER A 146
LEU A 257
ARG A 307
 None
 1.23A 5hwkA-3nuzA:
undetectable		 5hwkA-3nuzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 10 GLY A 258
GLY A 145
SER A 146
LEU A 257
ARG A 307
 None
 1.23A 5hwkB-3nuzA:
undetectable		 5hwkB-3nuzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 6 PHE A 388
VAL A 393
TYR A 363
ASP A 279
 None
 1.08A 5iwuA-3nuzA:
undetectable		 5iwuA-3nuzA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		4 / 8 PHE A  62
ALA A 327
PHE A  71
PRO A  58
 None
 0.97A 5m0oC-3nuzA:
undetectable		 5m0oC-3nuzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 10 ILE A 272
ALA A 274
ALA A 139
ILE A 140
ILE A 245
 None
 1.04A 5mvmD-3nuzA:
undetectable
5mvmE-3nuzA:
undetectable		 5mvmD-3nuzA:
12.57
5mvmE-3nuzA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3nuz PUTATIVE ACETYL
XYLAN ESTERASE
(Bacteroides
fragilis) 		5 / 12 VAL A 186
PRO A  89
PHE A  88
PRO A  97
PHE A 115
 None
 1.47A 6becA-3nuzA:
undetectable
6becB-3nuzA:
undetectable
6becC-3nuzA:
undetectable		 6becA-3nuzA:
21.12
6becB-3nuzA:
21.12
6becC-3nuzA:
21.12