SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 11 LEU A 331
SER A 377
MET A 364
LEU B  96
VAL B  87
 PEG  B1004 ( 4.1A)
None
None
None
PEG  B1004 (-3.3A)
 1.43A 1ee2B-3nv0A:
undetectable		 1ee2B-3nv0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 4 HIS A 337
VAL A 322
THR B 116
LEU A 326
 None
 1.19A 1oq5A-3nv0A:
undetectable		 1oq5A-3nv0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 PHE A 334
HIS A 337
ILE A 220
THR A 360
VAL A 365
 None
 1.47A 2gl0B-3nv0A:
undetectable
2gl0C-3nv0A:
undetectable		 2gl0B-3nv0A:
22.27
2gl0C-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 ILE A 220
THR A 360
VAL A 365
PHE A 334
HIS A 337
 None
 1.41A 2gl0A-3nv0A:
undetectable
2gl0C-3nv0A:
undetectable		 2gl0A-3nv0A:
22.27
2gl0C-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 PHE A 334
HIS A 337
ILE A 220
THR A 360
VAL A 365
 None
 1.44A 2gl0D-3nv0A:
undetectable
2gl0E-3nv0A:
undetectable		 2gl0D-3nv0A:
22.27
2gl0E-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 PHE A 334
HIS A 337
ILE A 220
THR A 360
VAL A 365
 None
 1.43A 2gl0E-3nv0A:
undetectable
2gl0F-3nv0A:
undetectable		 2gl0E-3nv0A:
22.27
2gl0F-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 11 ILE A 220
THR A 360
VAL A 365
PHE A 334
HIS A 337
 None
 1.43A 2gl0D-3nv0A:
undetectable
2gl0F-3nv0A:
undetectable		 2gl0D-3nv0A:
22.27
2gl0F-3nv0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 12 VAL A 365
ILE A 303
LEU A 380
ALA A 242
ASP B  79
 None
None
None
None
NA  B 452 (-3.4A)
 1.42A 2iyfB-3nv0A:
undetectable		 2iyfB-3nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans) 		5 / 10 MET B  65
PHE B  64
ALA B  48
LEU B 117
VAL B 128
 None
 1.40A 2wuzA-3nv0B:
undetectable		 2wuzA-3nv0B:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 8 GLN B  81
GLN A 285
ASP B  13
SER A 294
 None
None
PEG  A1001 (-2.8A)
PEG  A1001 ( 2.8A)
 1.07A 2xz5C-3nv0B:
undetectable
2xz5D-3nv0B:
undetectable		 2xz5C-3nv0B:
23.04
2xz5D-3nv0B:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 4 SER A 328
GLY B  89
GLY B 120
LYS B 129
 PEG  B1004 ( 4.4A)
None
None
NA  B 456 (-3.8A)
 1.28A 2y4nB-3nv0A:
undetectable		 2y4nB-3nv0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans) 		4 / 8 ALA B  48
TYR B  42
TRP B  50
ILE B  61
 None
 0.95A 2zm8A-3nv0B:
undetectable		 2zm8A-3nv0B:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 8 ASP A 342
PRO A 344
PRO A 311
GLN A 233
 NA  A 460 (-4.0A)
EDO  A1003 (-3.7A)
None
None
 1.10A 3oyaA-3nv0A:
undetectable		 3oyaA-3nv0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 ILE A 261
TRP A 258
ASP A 259
ARG A 389
ASP B 137
 NA  A 451 (-4.1A)
None
NA  A 451 (-2.6A)
None
None
 1.42A 3phaB-3nv0A:
undetectable		 3phaB-3nv0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		3 / 3 HIS A 337
SER A 383
ASN B  98
 None
None
NA  B 452 (-4.1A)
 0.74A 3s8pB-3nv0A:
undetectable		 3s8pB-3nv0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 TYR A 224
HIS A 315
GLN A 379
ILE A 375
TYR A 243
 None
 1.32A 4drhA-3nv0A:
undetectable		 4drhA-3nv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		5 / 12 TYR A 207
ILE A 220
PHE A 359
TYR A 358
LEU A 257
 None
None
None
NA  A 452 (-4.5A)
None
 1.32A 4j03A-3nv0A:
undetectable		 4j03A-3nv0A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 8 PRO B  84
SER A 377
VAL A 376
GLY B  93
 None
None
None
NA  B 455 (-3.5A)
 0.99A 4mk4A-3nv0B:
undetectable		 4mk4A-3nv0B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		4 / 8 PRO B  84
SER A 377
VAL A 376
GLY B  94
 None
 0.77A 4mk4A-3nv0B:
undetectable		 4mk4A-3nv0B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 ASN B  56
MET B  91
LEU A 326
VAL A 212
 NA  A 457 ( 3.2A)
PEG  B1004 ( 4.2A)
None
None
 1.19A 4okbA-3nv0B:
undetectable		 4okbA-3nv0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 PHE A 359
THR A 313
ILE A 314
ASP A 228
 None
None
None
NA  A 455 ( 3.5A)
 0.85A 4pcuA-3nv0A:
undetectable		 4pcuA-3nv0A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 7 VAL A 216
ILE A 220
PHE A 320
VAL A 322
 None
 0.79A 5bmvC-3nv0A:
undetectable		 5bmvC-3nv0A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3nv0 NUCLEAR RNA EXPORT
FACTOR 2
NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		3 / 3 HIS A 337
SER A 383
ASN B  98
 None
None
NA  B 452 (-4.1A)
 0.80A 5cprB-3nv0A:
undetectable		 5cprB-3nv0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans) 		4 / 4 ARG B  35
ILE B  38
TYR B  42
ILE B  61
 PEG  B1003 (-3.8A)
None
None
None
 1.00A 5odhG-3nv0B:
undetectable		 5odhG-3nv0B:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 LEU B  83
GLY B  94
GLY B  93
VAL B 121
LEU B  97
 None
None
NA  B 455 (-3.5A)
None
None
 1.17A 5uc1A-3nv0B:
undetectable		 5uc1A-3nv0B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
(Caenorhabditis
elegans) 		5 / 12 LEU B  83
GLY B  94
GLY B  93
VAL B 121
LEU B  97
 None
None
NA  B 455 (-3.5A)
None
None
 1.13A 5uc1B-3nv0B:
undetectable		 5uc1B-3nv0B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3nv0 NTF2-RELATED EXPORT
PROTEIN
NUCLEAR RNA EXPORT
FACTOR 2
(Caenorhabditis
elegans) 		4 / 6 VAL B  87
LEU A 331
LEU A 326
LEU B  96
 PEG  B1004 (-3.3A)
PEG  B1004 ( 4.1A)
None
None
 1.00A 6f6sA-3nv0B:
undetectable
6f6sB-3nv0B:
undetectable		 6f6sA-3nv0B:
17.09
6f6sB-3nv0B:
16.45