SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		5 / 9 LEU A 304
LEU A 203
LYS A 286
LEU A 279
GLU A 296
 None
 1.39A 1sn0A-3nv3A:
undetectable
1sn0C-3nv3A:
undetectable		 1sn0A-3nv3A:
19.59
1sn0C-3nv3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		5 / 10 ILE A 232
ALA A 233
ILE A 278
GLU A 311
ILE A 224
 None
 1.38A 2dm6A-3nv3A:
undetectable
2dm6B-3nv3A:
undetectable		 2dm6A-3nv3A:
17.37
2dm6B-3nv3A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 PRO A 263
SER A 261
GLU A 296
ARG A 247
 None
 1.05A 2v2gC-3nv3A:
undetectable
2v2gD-3nv3A:
undetectable		 2v2gC-3nv3A:
18.80
2v2gD-3nv3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 PRO A 263
SER A 261
GLU A 296
ARG A 247
 None
 1.07A 2v2gC-3nv3A:
undetectable
2v2gD-3nv3A:
undetectable		 2v2gC-3nv3A:
18.80
2v2gD-3nv3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 8 PRO A 263
SER A 261
GLU A 296
ARG A 247
 None
 0.93A 2v41C-3nv3A:
undetectable
2v41D-3nv3A:
undetectable		 2v41C-3nv3A:
18.80
2v41D-3nv3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 PRO A 263
SER A 261
GLU A 296
ARG A 247
 None
 1.02A 2v41E-3nv3A:
undetectable
2v41F-3nv3A:
undetectable		 2v41E-3nv3A:
18.80
2v41F-3nv3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 PRO A 263
SER A 261
GLU A 296
ARG A 247
 None
 0.97A 2v41E-3nv3A:
undetectable
2v41F-3nv3A:
undetectable		 2v41E-3nv3A:
18.80
2v41F-3nv3A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VTB_B_ACTB1500_0
(CRYPTOCHROME DASH)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 4 ARG A 264
PHE A 268
VAL A 289
ASP A 290
 None
 1.45A 2vtbB-3nv3A:
0.0		 2vtbB-3nv3A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 4 ARG A 264
GLN A 272
PHE A 274
LEU A 294
 None
 1.17A 3abkC-3nv3A:
undetectable		 3abkC-3nv3A:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		6 / 6 HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
 GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
 0.20A 3galA-3nv3A:
22.9		 3galA-3nv3A:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		6 / 6 HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
 GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
 0.29A 3galB-3nv3A:
22.9		 3galB-3nv3A:
38.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		3 / 3 ARG A 239
ASP A 315
ASP A 241
 NAG  A 502 ( 2.7A)
None
None
 0.63A 3jb3A-3nv3A:
undetectable		 3jb3A-3nv3A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		5 / 10 VAL A 287
PHE A 295
PHE A 222
ILE A 224
PHE A 268
 None
 1.26A 3t3rD-3nv3A:
undetectable		 3t3rD-3nv3A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 ARG A 221
VAL A 246
GLU A 258
ARG A 260
 None
None
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 1.31A 4mv7A-3nv3A:
undetectable		 4mv7A-3nv3A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		3 / 3 GLU A 311
ARG A 309
GLN A 250
 None
 0.94A 4rtbA-3nv3A:
undetectable		 4rtbA-3nv3A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 7 LEU A 318
THR A 323
THR A 197
LEU A 310
 None
 0.83A 4z91F-3nv3A:
undetectable
4z91G-3nv3A:
undetectable
4z91H-3nv3A:
undetectable
4z91I-3nv3A:
undetectable
4z91J-3nv3A:
undetectable		 4z91F-3nv3A:
18.40
4z91G-3nv3A:
18.40
4z91H-3nv3A:
18.40
4z91I-3nv3A:
18.40
4z91J-3nv3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		7 / 7 HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
ARG A 260
 GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 0.24A 6b8kA-3nv3A:
24.6		 6b8kA-3nv3A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		7 / 8 HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
ARG A 260
 GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 0.41A 6b94A-3nv3A:
19.4		 6b94A-3nv3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		7 / 10 HIS A 235
ASN A 237
ARG A 239
ASN A 248
TRP A 255
GLU A 258
ARG A 260
 GAL  A 501 (-3.9A)
GAL  A 501 (-3.8A)
NAG  A 502 ( 2.7A)
GAL  A 501 (-3.8A)
GAL  A 501 (-3.6A)
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 0.39A 6b94A-3nv3A:
19.4
6b94B-3nv3A:
18.6		 6b94A-3nv3A:
23.31
6b94B-3nv3A:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 4 ARG A 239
GLU A 242
GLU A 258
ARG A 260
 NAG  A 502 ( 2.7A)
None
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 0.54A 6fk2A-3nv3A:
24.7		 6fk2A-3nv3A:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FK2_A_SORA302_0
(GALECTIN-3)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 4 ARG A 260
GLU A 258
GLU A 242
ARG A 239
 NAG  A 502 (-4.0A)
NAG  A 502 ( 2.7A)
None
NAG  A 502 ( 2.7A)
 1.03A 6fk2A-3nv3A:
24.7		 6fk2A-3nv3A:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens) 		4 / 6 ARG A 264
GLN A 272
PHE A 274
LEU A 294
 None
 1.17A 6nmpC-3nv3A:
undetectable
6nmpJ-3nv3A:
undetectable		 6nmpC-3nv3A:
20.76
6nmpJ-3nv3A:
19.23