SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 7 TYR A 334
GLU A 332
PHE A 353
ARG A 350
 None
 1.35A 1b2iA-3nv9A:
undetectable		 1b2iA-3nv9A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 ALA A 445
TRP A 438
TYR A 442
GLY A 365
 None
 0.83A 1rukH-3nv9A:
undetectable
1rukL-3nv9A:
undetectable		 1rukH-3nv9A:
16.70
1rukL-3nv9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 7 PHE A  92
ILE A 137
ILE A 135
THR A 161
 None
 0.99A 1sbrB-3nv9A:
undetectable		 1sbrB-3nv9A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 GLY A 197
THR A 198
ALA A 199
TYR A 176
 None
 0.70A 2a1hA-3nv9A:
undetectable
2a1hB-3nv9A:
undetectable		 2a1hA-3nv9A:
22.67
2a1hB-3nv9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 TYR A 176
GLY A 197
THR A 198
ALA A 199
 None
 0.73A 2a1hA-3nv9A:
undetectable
2a1hB-3nv9A:
undetectable		 2a1hA-3nv9A:
22.67
2a1hB-3nv9A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 9 ASN A 355
ILE A 345
ILE A 399
GLY A 205
ALA A 209
 None
 1.18A 2dtjA-3nv9A:
undetectable
2dtjB-3nv9A:
undetectable		 2dtjA-3nv9A:
18.07
2dtjB-3nv9A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 7 GLU A 446
LYS A 368
PRO A 415
ALA A 418
 None
 1.14A 2ejgA-3nv9A:
undetectable		 2ejgA-3nv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 7 GLU A 446
LYS A 368
PRO A 415
ALA A 418
 None
 1.25A 2ejgB-3nv9A:
undetectable		 2ejgB-3nv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 SER A 171
THR A 100
VAL A 151
ALA A 150
VAL A 181
 None
 1.12A 2nniA-3nv9A:
undetectable		 2nniA-3nv9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 ALA A 204
LEU A 207
ALA A 241
THR A 240
 None
 0.87A 3b6hA-3nv9A:
undetectable		 3b6hA-3nv9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 ALA A 204
LEU A 207
ALA A 241
THR A 240
 None
 0.84A 3b6hB-3nv9A:
undetectable		 3b6hB-3nv9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 PHE A 363
LEU A 371
GLY A 129
GLY A 128
ALA A 132
 None
 1.12A 3i5uA-3nv9A:
3.1		 3i5uA-3nv9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 ASN A 166
ASP A 193
VAL A 201
GLY A 365
ILE A 366
 None
 1.14A 3k13A-3nv9A:
undetectable		 3k13A-3nv9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 ASN A 166
ASP A 193
VAL A 201
GLY A 365
ILE A 366
 None
 1.16A 3k13B-3nv9A:
undetectable		 3k13B-3nv9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 ASN A 166
ASP A 193
VAL A 201
GLY A 365
ILE A 366
 None
 1.16A 3k13C-3nv9A:
undetectable		 3k13C-3nv9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 GLY A 242
ALA A 204
GLY A 205
LEU A 210
ILE A 217
 None
 1.10A 3ku1G-3nv9A:
3.6		 3ku1G-3nv9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 LEU A 390
ARG A 388
GLY A 406
THR A 407
LEU A 207
 None
 1.23A 3okxB-3nv9A:
undetectable		 3okxB-3nv9A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 GLY A 406
GLY A 205
ALA A 204
ALA A 199
SER A 230
 None
 1.09A 3sudA-3nv9A:
undetectable		 3sudA-3nv9A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 5 ILE A 130
PRO A 364
LYS A 125
GLY A 128
 None
 1.07A 3tkdB-3nv9A:
undetectable		 3tkdB-3nv9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 5 ILE A 130
PRO A 364
LYS A 125
GLY A 128
 None
 1.07A 3tkdA-3nv9A:
undetectable		 3tkdA-3nv9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 THR A 198
ASN A 359
GLY A 362
ILE A 405
 None
GOL  A 497 (-3.3A)
None
None
 0.91A 3w9tF-3nv9A:
undetectable		 3w9tF-3nv9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 ILE A 322
PHE A 324
SER A 387
GLY A 205
 None
 0.80A 4acaC-3nv9A:
3.9		 4acaC-3nv9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 ILE A 322
PHE A 324
SER A 387
GLY A 205
 None
 0.78A 4acbC-3nv9A:
undetectable		 4acbC-3nv9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 11 TYR A 271
GLN A 195
ASN A 174
LEU A 179
VAL A 181
 None
None
GOL  A 499 ( 4.9A)
None
None
 1.44A 4k37B-3nv9A:
undetectable		 4k37B-3nv9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 ILE A 366
PHE A 363
GLY A 197
ILE A 405
 None
 0.76A 4o8fB-3nv9A:
undetectable		 4o8fB-3nv9A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 GLU A 392
ASN A 208
ALA A 204
GLY A 205
LEU A 206
 None
 1.40A 4oadA-3nv9A:
undetectable		 4oadA-3nv9A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 ASP A 193
GLY A 197
LEU A 237
ASP A 380
ILE A 366
 None
None
None
SO4  A 488 (-3.8A)
None
 1.42A 4pghB-3nv9A:
undetectable		 4pghB-3nv9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		3 / 3 VAL A 361
PHE A 393
ARG A 397
 None
 0.92A 4xr4B-3nv9A:
5.0		 4xr4B-3nv9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 8 ILE A 158
SER A 185
LEU A 179
ILE A 165
 None
 0.96A 4xtaB-3nv9A:
undetectable		 4xtaB-3nv9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 7 ILE A 366
GLY A 197
THR A 379
TRP A 191
 None
None
SO4  A 488 (-4.1A)
None
 1.16A 4zxiA-3nv9A:
2.6		 4zxiA-3nv9A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 VAL A 421
ASP A 420
GLU A 417
LEU A 371
PRO A 415
 None
 1.30A 5hnxB-3nv9A:
undetectable		 5hnxB-3nv9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 9 ALA A 445
ASP A 443
GLY A 412
ILE A 413
VAL A 421
 None
 1.12A 5kr0A-3nv9A:
undetectable		 5kr0A-3nv9A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 LEU A 390
GLY A 197
PRO A 364
ASP A 193
THR A 198
 None
 1.22A 5x6yC-3nv9A:
undetectable		 5x6yC-3nv9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 ARG A 101
GLY A 106
SER A 171
VAL A 108
 GOL  A 498 (-4.8A)
None
None
None
 1.06A 5ysiA-3nv9A:
undetectable		 5ysiA-3nv9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		3 / 3 LYS A 273
LEU A 257
ARG A 261
 SO4  A 492 ( 4.0A)
None
None
 0.88A 5yw0A-3nv9A:
undetectable		 5yw0A-3nv9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		4 / 6 MET A 124
GLY A 365
ALA A 370
LEU A 371
 None
 0.85A 6fosA-3nv9A:
3.1		 6fosA-3nv9A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3nv9 MALIC ENZYME
(Entamoeba
histolytica) 		5 / 12 VAL A 155
ILE A 158
SER A  99
VAL A  95
ILE A 135
 None
 1.47A 6gsdA-3nv9A:
2.7		 6gsdA-3nv9A:
9.88