SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A 312
PRO A 358
GLU A 513
ARG A 465
 None
 1.22A 1oniA-3nvaA:
undetectable
1oniC-3nvaA:
undetectable		 1oniA-3nvaA:
15.78
1oniC-3nvaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 5 ARG A 465
ILE A 312
PRO A 358
GLU A 513
 None
 1.27A 1oniG-3nvaA:
undetectable
1oniH-3nvaA:
undetectable		 1oniG-3nvaA:
15.78
1oniH-3nvaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 GLN A 390
HIS A 466
ARG A 465
 None
 1.03A 1zlqA-3nvaA:
undetectable		 1zlqA-3nvaA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 348
ILE A 372
ALA A 371
THR A 303
VAL A 356
 None
 1.11A 2g78A-3nvaA:
undetectable		 2g78A-3nvaA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 445
ILE A 450
ALA A 451
VAL A 506
ARG A 437
 None
 1.11A 2g78A-3nvaA:
undetectable		 2g78A-3nvaA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 531
ILE A 529
ILE A 294
GLY A 353
ILE A 354
 None
 0.94A 2o4nA-3nvaA:
undetectable		 2o4nA-3nvaA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 ASN A 412
ASN A 407
ARG A 398
 None
 0.80A 2rlcA-3nvaA:
undetectable		 2rlcA-3nvaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 235
PHE A 209
SER A 260
 None
 1.00A 3i5uB-3nvaA:
2.0		 3i5uB-3nvaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 296
GLY A 353
ALA A 375
ALA A 531
VAL A 532
 None
 1.08A 3jb3A-3nvaA:
undetectable		 3jb3A-3nvaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		6 / 9 ILE A 296
VAL A 532
GLY A 527
ILE A 524
ILE A 312
ILE A 316
 None
 1.48A 3s43A-3nvaA:
undetectable		 3s43A-3nvaA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 487
LEU A 493
GLY A 492
ALA A 451
PHE A 389
 None
 1.16A 3vywC-3nvaA:
undetectable		 3vywC-3nvaA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A  76
ASP A  70
ASP A 307
 None
 0.84A 4a6eA-3nvaA:
undetectable		 4a6eA-3nvaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A   5
VAL A   7
ILE A 143
GLU A 165
 None
 1.10A 4a97E-3nvaA:
undetectable		 4a97E-3nvaA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 136
ILE A 127
LEU A 140
VAL A  39
ILE A  90
 None
 0.98A 4aztA-3nvaA:
undetectable		 4aztA-3nvaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 136
ILE A 127
LEU A 140
VAL A  39
ILE A  90
 None
 0.94A 4azvA-3nvaA:
undetectable		 4azvA-3nvaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A  72
TRP A 278
SER A  14
 None
 0.98A 4lrhA-3nvaA:
undetectable		 4lrhA-3nvaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  21
LEU A 258
LYS A 261
SER A 260
ARG A  32
 None
 1.23A 4q0dC-3nvaA:
3.8		 4q0dC-3nvaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  21
LEU A 258
LYS A 261
SER A 260
ARG A  32
 None
 1.23A 4q0dD-3nvaA:
3.8		 4q0dD-3nvaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A 314
THR A  20
HIS A  75
 None
 0.83A 4q15A-3nvaA:
3.7		 4q15A-3nvaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A 314
THR A  20
HIS A  75
 None
 0.85A 4q15B-3nvaA:
2.3		 4q15B-3nvaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 451
SER A 486
GLY A 487
GLU A 513
TYR A 455
 None
 1.23A 4r29B-3nvaA:
undetectable		 4r29B-3nvaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 136
ILE A 127
LEU A 140
VAL A  39
ILE A  90
 None
 0.98A 4uw0A-3nvaA:
undetectable		 4uw0A-3nvaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 266
LEU A  21
ILE A  25
LEU A  29
VAL A 174
 None
 1.00A 4y0qA-3nvaA:
undetectable		 4y0qA-3nvaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A 314
THR A  20
HIS A  75
 None
 0.77A 4ydqB-3nvaA:
3.6		 4ydqB-3nvaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 409
ILE A 420
PHE A 360
LEU A 423
 None
 0.80A 5fukA-3nvaA:
undetectable
5fukB-3nvaA:
undetectable		 5fukA-3nvaA:
18.78
5fukB-3nvaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 119
PRO A  43
ALA A  92
VAL A  95
ILE A 205
 None
 1.23A 5hv1A-3nvaA:
undetectable		 5hv1A-3nvaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 THR A 230
VAL A 232
PRO A 207
ILE A 205
 None
 1.22A 5vkqA-3nvaA:
undetectable
5vkqB-3nvaA:
undetectable		 5vkqA-3nvaA:
15.79
5vkqB-3nvaA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 299
GLY A 384
ALA A 507
LEU A 483
LEU A 499
 None
 1.24A 5x23A-3nvaA:
undetectable		 5x23A-3nvaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_C_9F2C302_1
(BETA-LACTAMASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 10 TYR A   5
THR A 139
ILE A 127
THR A  85
ASP A 121
 None
 1.47A 6b68C-3nvaA:
undetectable
6b68D-3nvaA:
undetectable		 6b68C-3nvaA:
11.71
6b68D-3nvaA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_C_9F2C302_1
(BETA-LACTAMASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 9 TYR A   5
THR A 139
ILE A 127
THR A  85
ASP A 121
 None
 1.45A 6b6aC-3nvaA:
undetectable
6b6aD-3nvaA:
undetectable		 6b6aC-3nvaA:
11.71
6b6aD-3nvaA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A 173
ILE A 172
SER A 131
VAL A 141
ILE A   6
 None
 1.48A 6gsdA-3nvaA:
3.4		 6gsdA-3nvaA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3nva CTP SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 115
GLU A 103
HIS A 118
VAL A 119
 None
 1.18A 6j20A-3nvaA:
undetectable		 6j20A-3nvaA:
20.88