SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 ASP A 424
HIS A 428
HIS A 466
HIS A 495
 CO  A 554 (-2.3A)
CO  A 554 (-3.3A)
CO  A 553 (-3.2A)
CO  A 554 (-3.3A)
 0.45A 1ei6A-3nvlA:
17.9		 1ei6A-3nvlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 8 ASP A  22
ASP A 424
HIS A 428
HIS A 466
HIS A 495
 CO  A 553 (-2.1A)
CO  A 554 (-2.3A)
CO  A 554 (-3.3A)
CO  A 553 (-3.2A)
CO  A 554 (-3.3A)
 0.51A 1ei6C-3nvlA:
17.6		 1ei6C-3nvlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.53A 1fbmB-3nvlA:
undetectable		 1fbmB-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.64A 1fbmD-3nvlA:
undetectable		 1fbmD-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.57A 1fbmE-3nvlA:
undetectable		 1fbmE-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 4 ILE A 144
LEU A 179
VAL A 158
ILE A 156
 None
 0.89A 1fm6D-3nvlA:
undetectable		 1fm6D-3nvlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 GLU A 270
ASP A 273
ILE A 266
ALA A 196
THR A 122
 None
 1.00A 1kijB-3nvlA:
undetectable		 1kijB-3nvlA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.62A 1mz9D-3nvlA:
undetectable		 1mz9D-3nvlA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 1.06A 1p6kA-3nvlA:
undetectable		 1p6kA-3nvlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 0.97A 1p6kB-3nvlA:
undetectable		 1p6kB-3nvlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 1.11A 1rs6A-3nvlA:
undetectable		 1rs6A-3nvlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 1.01A 1rs6B-3nvlA:
undetectable		 1rs6B-3nvlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 1.08A 1zzqA-3nvlA:
undetectable		 1zzqA-3nvlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 1.00A 1zzqB-3nvlA:
undetectable		 1zzqB-3nvlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 0.97A 1zzuA-3nvlA:
undetectable		 1zzuA-3nvlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 SER A  74
ASN A 419
GLN A 355
ASP A 319
 CO  A 553 (-2.2A)
None
None
CO  A 554 (-2.4A)
 0.97A 1zzuB-3nvlA:
undetectable		 1zzuB-3nvlA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 GLU A 217
PRO A 254
ARG A 218
GLY A 219
 None
 1.24A 2hs1B-3nvlA:
undetectable		 2hs1B-3nvlA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 6 ASP A 471
ARG A 475
ASP A 476
ASP A  30
 None
 0.97A 2j2pE-3nvlA:
undetectable
2j2pF-3nvlA:
undetectable		 2j2pE-3nvlA:
17.60
2j2pF-3nvlA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 LEU A  21
ASP A 470
LEU A 461
HIS A  78
 None
 1.01A 2jfaA-3nvlA:
undetectable		 2jfaA-3nvlA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 428
GLY A  72
HIS A 495
ASP A 319
ASP A 317
 CO  A 554 (-3.3A)
None
CO  A 554 (-3.3A)
CO  A 554 (-2.4A)
None
 1.15A 2pgrA-3nvlA:
undetectable		 2pgrA-3nvlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 428
GLY A  72
HIS A 495
ASP A 424
ASP A  22
 CO  A 554 (-3.3A)
None
CO  A 554 (-3.3A)
CO  A 554 (-2.3A)
CO  A 553 (-2.1A)
 1.03A 2pgrA-3nvlA:
undetectable		 2pgrA-3nvlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 HIS A 495
HIS A 428
ASP A  22
GLY A  23
 CO  A 554 (-3.3A)
CO  A 554 (-3.3A)
CO  A 553 (-2.1A)
CO  A 553 ( 4.9A)
 0.90A 3c0zB-3nvlA:
3.1		 3c0zB-3nvlA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 10 ALA A 222
ILE A 269
GLY A 267
ILE A 266
ALA A 160
 None
 0.93A 3ekwA-3nvlA:
undetectable		 3ekwA-3nvlA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 PRO A 265
THR A 205
VAL A 204
GLY A 219
 None
 0.98A 3elzA-3nvlA:
undetectable		 3elzA-3nvlA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 ASP A 470
ASP A 471
ASP A 465
ASP A 319
 None
None
CO  A 553 (-2.3A)
CO  A 554 (-2.4A)
 1.11A 3havA-3nvlA:
undetectable		 3havA-3nvlA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 LEU A 497
THR A 496
GLY A  23
ALA A 464
 None
None
CO  A 553 ( 4.9A)
None
 0.84A 3jusA-3nvlA:
undetectable		 3jusA-3nvlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 8 LEU A 497
THR A 496
GLY A  23
ALA A 464
 None
None
CO  A 553 ( 4.9A)
None
 0.84A 3jusA-3nvlA:
undetectable		 3jusA-3nvlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 VAL A 500
GLY A 467
VAL A  76
VAL A  63
 None
 0.73A 3ufnB-3nvlA:
undetectable		 3ufnB-3nvlA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 GLY A 108
TYR A 310
TYR A 111
GLU A 293
 None
 1.47A 4ae1B-3nvlA:
undetectable		 4ae1B-3nvlA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 10 ILE A 195
LEU A 179
GLY A 198
TYR A 162
PHE A 278
 None
 1.17A 4bwlC-3nvlA:
undetectable		 4bwlC-3nvlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 495
HIS A 428
GLY A 427
ASP A  22
GLY A  23
 CO  A 554 (-3.3A)
CO  A 554 (-3.3A)
None
CO  A 553 (-2.1A)
CO  A 553 ( 4.9A)
 1.18A 4bz6C-3nvlA:
3.5		 4bz6C-3nvlA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 ASN A 533
GLU A 549
ILE A 548
ASN A 526
 None
 1.06A 4d39B-3nvlA:
undetectable		 4d39B-3nvlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 10 VAL A 275
ALA A 311
PHE A 297
LEU A 305
VAL A 308
 None
 1.45A 4eilB-3nvlA:
2.8		 4eilB-3nvlA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 PHE A 531
ASN A 365
GLY A  82
THR A 528
 None
 0.88A 4ejjA-3nvlA:
undetectable		 4ejjA-3nvlA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 PRO A 421
ASP A  22
HIS A 359
SER A  74
 None
CO  A 553 (-2.1A)
None
CO  A 553 (-2.2A)
 1.13A 4k7gB-3nvlA:
undetectable		 4k7gB-3nvlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 6 ARG A 304
ARG A 121
ASP A 271
ASP A 273
 None
 1.32A 4kcnA-3nvlA:
undetectable		 4kcnA-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 6 ARG A 304
ARG A 121
ASP A 271
ASP A 273
 None
 1.34A 4kcnB-3nvlA:
undetectable		 4kcnB-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 495
HIS A 428
GLY A 427
ASP A  22
GLY A  23
 CO  A 554 (-3.3A)
CO  A 554 (-3.3A)
None
CO  A 553 (-2.1A)
CO  A 553 ( 4.9A)
 1.18A 4lxzA-3nvlA:
undetectable		 4lxzA-3nvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 HIS A 495
HIS A 428
GLY A 427
ASP A  22
GLY A  23
 CO  A 554 (-3.3A)
CO  A 554 (-3.3A)
None
CO  A 553 (-2.1A)
CO  A 553 ( 4.9A)
 1.17A 4lxzC-3nvlA:
undetectable		 4lxzC-3nvlA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 ILE A 382
ARG A 386
GLU A 353
VAL A 360
 None
 1.21A 4nkxC-3nvlA:
undetectable		 4nkxC-3nvlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 ILE A 382
ARG A 386
GLU A 353
VAL A 360
 None
 1.19A 4nkxD-3nvlA:
undetectable		 4nkxD-3nvlA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		3 / 3 ASP A  22
ASP A 465
ASN A  79
 CO  A 553 (-2.1A)
CO  A 553 (-2.3A)
None
 0.76A 4q5mA-3nvlA:
undetectable		 4q5mA-3nvlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 11 GLY A 198
ILE A 269
THR A 268
GLY A 267
ILE A 266
 None
 0.82A 4qgiA-3nvlA:
undetectable		 4qgiA-3nvlA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 GLY A 198
GLY A 219
SER A 197
ALA A 234
ALA A 160
 None
 0.92A 4uciA-3nvlA:
3.7		 4uciA-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 GLY A 198
GLY A 219
SER A 197
ALA A 234
ALA A 160
 None
 0.92A 4uciB-3nvlA:
3.7		 4uciB-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 GLY A 198
GLY A 219
SER A 197
ALA A 234
ALA A 160
 None
 0.94A 4uckA-3nvlA:
3.8		 4uckA-3nvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 6 PHE A 379
ARG A 417
ILE A 348
GLU A 377
 None
 1.22A 4zzcA-3nvlA:
undetectable
4zzcB-3nvlA:
undetectable		 4zzcA-3nvlA:
20.97
4zzcB-3nvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 PHE A 379
ARG A 417
ILE A 348
GLU A 377
 None
 1.26A 4zzcC-3nvlA:
1.2
4zzcD-3nvlA:
1.2		 4zzcC-3nvlA:
20.97
4zzcD-3nvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 5 SER A 197
VAL A 257
GLY A 228
ALA A 222
 None
 1.08A 5k50A-3nvlA:
4.2		 5k50A-3nvlA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 7 THR A 122
ARG A 121
ARG A 157
ASP A 192
 None
 1.24A 5uxcA-3nvlA:
undetectable		 5uxcA-3nvlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		5 / 12 MET A 535
SER A 337
GLU A 339
LEU A 341
ILE A 348
 None
 1.12A 5vlmA-3nvlA:
1.7		 5vlmA-3nvlA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Trypanosoma
brucei) 		4 / 6 LYS A 240
ARG A 235
GLU A 236
ALA A 234
 None
 0.88A 6an0A-3nvlA:
4.2		 6an0A-3nvlA:
21.44