SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 7 MET B 333
SER B 297
PHE B 238
ALA B 307
 None
 1.19A 1fxvA-3nvnB:
undetectable
1fxvB-3nvnB:
undetectable		 1fxvA-3nvnB:
17.83
1fxvB-3nvnB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 11 VAL B 309
LEU B 400
LEU B 376
LEU B 441
LEU B 399
 None
 1.43A 1mx1B-3nvnB:
undetectable		 1mx1B-3nvnB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 9 SER B  42
VAL B 447
GLU B 446
SER B  61
ILE B  49
 None
 1.50A 1pw7C-3nvnB:
undetectable		 1pw7C-3nvnB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3nvn PLEXIN-C1
(Homo
sapiens) 		3 / 3 TYR B 248
ARG B 362
GLN B 359
 None
 0.96A 1tw4A-3nvnB:
1.7		 1tw4A-3nvnB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 11 GLY B  56
ALA B  51
ALA B  50
LEU B 109
VAL B 430
 None
 1.11A 1ukbA-3nvnB:
undetectable		 1ukbA-3nvnB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 6 SER B 297
TYR B 248
SER B 243
GLN B 276
 None
 1.39A 2cl5B-3nvnB:
undetectable		 2cl5B-3nvnB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 10 ILE B 439
PRO B 431
ILE B 437
HIS B 471
TYR B 380
 None
 1.36A 2jkcA-3nvnB:
undetectable		 2jkcA-3nvnB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 ILE B 439
PRO B 431
ILE B 437
HIS B 471
TYR B 380
 None
 1.26A 2oa1B-3nvnB:
0.0		 2oa1B-3nvnB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 5 ILE B 437
ARG B 451
ARG B 449
ASP B 432
 None
 0.97A 2rhmD-3nvnB:
undetectable		 2rhmD-3nvnB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3nvn PLEXIN-C1
(Homo
sapiens) 		3 / 3 TYR B 183
VAL B 179
THR B 182
 None
 0.86A 2ygnA-3nvnB:
undetectable		 2ygnA-3nvnB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 8 ALA B 133
GLY B 132
THR B 151
ARG B  81
 None
 0.91A 3rglA-3nvnB:
undetectable		 3rglA-3nvnB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 6 SER B 311
LEU B 376
THR B 325
ARG B 321
 None
 1.22A 3thrB-3nvnB:
undetectable		 3thrB-3nvnB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 LEU B  72
GLY B  56
PHE B  58
LEU B  65
ILE B  49
 None
 1.02A 4hytA-3nvnB:
undetectable		 4hytA-3nvnB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 LEU B  72
GLY B  56
PHE B  58
LEU B  65
ILE B  49
 None
 1.02A 4hytC-3nvnB:
undetectable		 4hytC-3nvnB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 GLY B  56
ILE B  49
THR B 125
VAL B 447
ILE B  46
 None
 0.84A 4q5mA-3nvnB:
undetectable		 4q5mA-3nvnB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 GLU B 135
LEU B 177
GLY B 132
TYR B 183
ALA B 181
 None
 1.31A 5j7wC-3nvnB:
undetectable		 5j7wC-3nvnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3nvn PLEXIN-C1
(Homo
sapiens) 		4 / 8 SER B 311
THR B 325
ARG B 100
PRO B 101
 None
 1.04A 5jhdE-3nvnB:
undetectable
5jhdG-3nvnB:
undetectable		 5jhdE-3nvnB:
18.26
5jhdG-3nvnB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 PHE B 234
ALA B 204
GLY B 221
GLY B 164
ALA B 163
 None
 0.95A 5w4zA-3nvnB:
undetectable		 5w4zA-3nvnB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 PHE B 234
ALA B 204
GLY B 221
GLY B 164
ALA B 163
 None
 0.96A 5w4zB-3nvnB:
undetectable		 5w4zB-3nvnB:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 9 TYR B 248
ALA B 163
ALA B 181
LEU B 225
LEU B 223
 None
 1.18A 6ay6A-3nvnB:
undetectable		 6ay6A-3nvnB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 12 ALA B 350
TYR B 248
ALA B 163
ALA B 181
LEU B 225
 None
 1.25A 6aycA-3nvnB:
undetectable		 6aycA-3nvnB:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 9 VAL B 166
LEU B 177
GLY B 126
LEU B 108
VAL B 136
 None
 1.14A 6czmA-3nvnB:
undetectable
6czmB-3nvnB:
undetectable		 6czmA-3nvnB:
23.32
6czmB-3nvnB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 9 VAL B 166
LEU B 177
GLY B 126
LEU B 108
VAL B 136
 None
 1.13A 6czmD-3nvnB:
undetectable
6czmE-3nvnB:
undetectable		 6czmD-3nvnB:
23.32
6czmE-3nvnB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3nvn PLEXIN-C1
(Homo
sapiens) 		5 / 10 ARG B 291
VAL B 309
LEU B 295
SER B 296
LEU B 429
 None
 1.16A 6eu9B-3nvnB:
undetectable		 6eu9B-3nvnB:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3nvn PLEXIN-C1
(Homo
sapiens) 		3 / 3 ARG B 387
GLY B 405
GLU B 406
 None
 0.54A 6fgdA-3nvnB:
undetectable		 6fgdA-3nvnB:
21.20