SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 GLY A  91
GLY A  90
TYR A  96
VAL A 160
 None
 0.70A 1dbbH-3nvqA:
undetectable
1dbbL-3nvqA:
undetectable		 1dbbH-3nvqA:
16.75
1dbbL-3nvqA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 THR A 377
THR A 375
PRO A 374
 None
 0.84A 1dscC-3nvqA:
undetectable		 1dscC-3nvqA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 11 LEU A 427
VAL A 324
VAL A 336
GLY A 323
GLU A 441
 None
 1.04A 1jkhA-3nvqA:
undetectable
1jkhB-3nvqA:
undetectable		 1jkhA-3nvqA:
21.26
1jkhB-3nvqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 12 PRO A 400
ALA A 333
VAL A 259
GLU A 246
PHE A 244
 None
 1.01A 1sg9C-3nvqA:
undetectable		 1sg9C-3nvqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 12 THR A 430
ILE A 456
VAL A 488
ILE A 465
LEU A 477
 None
 1.18A 1z9hD-3nvqA:
undetectable		 1z9hD-3nvqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 THR A 377
THR A 375
PRO A 374
 None
 0.85A 209dC-3nvqA:
undetectable		 209dC-3nvqA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 SER A 520
GLU A 102
ASP A 471
 None
 0.53A 2avdB-3nvqA:
undetectable		 2avdB-3nvqA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 7 SER A  85
ASP A  99
SER A  86
SER A  84
 None
 1.14A 2cmlA-3nvqA:
4.2		 2cmlA-3nvqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 10 THR A 467
LEU A 133
VAL A  77
GLY A  90
VAL A 485
 None
 1.12A 2cp4A-3nvqA:
undetectable		 2cp4A-3nvqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 TYR A 408
GLN A 304
ARG A 245
ASP A 432
 None
None
None
NDG  A   4 (-3.9A)
 1.13A 2xytE-3nvqA:
undetectable		 2xytE-3nvqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 TYR A 408
GLN A 304
ARG A 245
ASP A 432
 None
None
None
NDG  A   4 (-3.9A)
 1.08A 2xytH-3nvqA:
undetectable		 2xytH-3nvqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 7 VAL A 160
ASN A 128
GLY A  93
VAL A  95
 None
 0.77A 2y05A-3nvqA:
undetectable
2y05B-3nvqA:
undetectable		 2y05A-3nvqA:
19.42
2y05B-3nvqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 5 VAL A 321
VAL A 336
THR A 319
ARG A 320
 None
 1.21A 3bjwA-3nvqA:
undetectable		 3bjwA-3nvqA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 6 ILE A 229
THR A 319
PHE A 243
TYR A 241
 None
 1.14A 3elzB-3nvqA:
2.5		 3elzB-3nvqA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 TYR A 611
LEU A 556
TYR A 562
TYR A 608
 None
 1.21A 3po7A-3nvqA:
undetectable		 3po7A-3nvqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 7 PRO A 150
LEU A 141
GLY A 168
ALA A 170
 None
 0.99A 3tehB-3nvqA:
undetectable		 3tehB-3nvqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 ASP A 343
ARG A 347
ASP A 238
 None
 0.82A 4fp9A-3nvqA:
undetectable		 4fp9A-3nvqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 GLN A 409
THR A 431
THR A 430
 None
 0.72A 4fu9A-3nvqA:
undetectable		 4fu9A-3nvqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 GLN A 409
THR A 431
THR A 430
 None
 0.68A 4fufA-3nvqA:
undetectable		 4fufA-3nvqA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 THR A 467
LEU A 133
VAL A  77
VAL A 485
 None
 1.17A 4l4dA-3nvqA:
undetectable		 4l4dA-3nvqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 THR A 467
LEU A 133
VAL A  77
VAL A 485
 None
 1.14A 4l4fA-3nvqA:
undetectable		 4l4fA-3nvqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 GLY A  93
THR A 110
ASN A 112
ARG A  92
 None
 1.24A 4m5mA-3nvqA:
undetectable		 4m5mA-3nvqA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 12 ASP A 343
VAL A 262
ALA A 263
TYR A 241
VAL A 387
 None
 1.23A 4mm6A-3nvqA:
undetectable		 4mm6A-3nvqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 TYR A 406
GLY A  51
PRO A  52
 None
 0.57A 4qwpA-3nvqA:
undetectable		 4qwpA-3nvqA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 5 LEU A 490
ASP A 491
TYR A 478
LEU A 477
 None
 1.22A 4wozF-3nvqA:
undetectable
4wozH-3nvqA:
undetectable		 4wozF-3nvqA:
19.90
4wozH-3nvqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 7 GLY A 271
TYR A 213
SER A 277
ASN A 282
 None
 1.12A 4ws0A-3nvqA:
undetectable		 4ws0A-3nvqA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 5 ARG A 136
GLY A 139
GLU A 138
SER A  84
 None
 1.00A 4z3oA-3nvqA:
undetectable
4z3oB-3nvqA:
undetectable		 4z3oA-3nvqA:
20.72
4z3oB-3nvqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 5 SER A  84
ARG A 136
GLY A 139
GLU A 138
 None
 0.94A 5cdqA-3nvqA:
undetectable
5cdqB-3nvqA:
undetectable
5cdqC-3nvqA:
undetectable		 5cdqA-3nvqA:
21.50
5cdqB-3nvqA:
15.60
5cdqC-3nvqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 5 SER A  84
ARG A 136
GLY A 139
GLU A 138
 None
 0.93A 5cdqR-3nvqA:
undetectable
5cdqS-3nvqA:
undetectable
5cdqT-3nvqA:
undetectable		 5cdqR-3nvqA:
21.50
5cdqS-3nvqA:
15.60
5cdqT-3nvqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		3 / 3 VAL A  77
ARG A 167
PRO A 150
 None
 0.54A 5koxA-3nvqA:
undetectable		 5koxA-3nvqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 7 VAL A 324
PHE A 402
LEU A 429
THR A 430
THR A 431
 None
 1.45A 5m78A-3nvqA:
undetectable		 5m78A-3nvqA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		5 / 12 ALA A 106
GLU A 102
GLY A 103
GLU A 494
LEU A 492
 None
 1.20A 5ul4A-3nvqA:
undetectable		 5ul4A-3nvqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3nvq SEMAPHORIN-7A
(Homo
sapiens) 		4 / 8 THR A 214
TYR A 242
PHE A 244
PRO A 222
 None
 1.04A 5v4vA-3nvqA:
undetectable		 5v4vA-3nvqA:
19.90