SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 LEU A  30
LEU A  36
GLY A  35
THR A  24
ILE A  77
 None
 1.41A 1p93A-3nvyA:
undetectable		 1p93A-3nvyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		3 / 3 LEU A   6
PHE A   8
ARG A  32
 None
 0.85A 1xdkF-3nvyA:
undetectable		 1xdkF-3nvyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 LEU A  80
ASP A  59
ILE A  65
VAL A  85
VAL A  83
 None
 0.97A 2nnkA-3nvyA:
undetectable		 2nnkA-3nvyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 10 GLY A 145
ALA A  50
GLY A  49
CYH A  43
CYH A  51
 None
FES  A 602 ( 4.7A)
FES  A 602 (-3.9A)
FES  A 602 (-2.3A)
FES  A 602 (-2.2A)
 1.15A 4c5lC-3nvyA:
undetectable		 4c5lC-3nvyA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		5 / 12 LEU A  55
SER A 123
LEU A  26
THR A  25
GLY A  46
 None
None
None
None
FES  A 602 ( 3.2A)
 0.95A 6b0cD-3nvyA:
undetectable		 6b0cD-3nvyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 8 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 1.00A 6c06C-3nvyA:
undetectable		 6c06C-3nvyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E
(Bos
taurus) 		4 / 6 ALA A  50
THR A 151
ILE A 156
PHE A 160
 FES  A 602 ( 4.7A)
FES  A 601 ( 4.7A)
None
None
 0.89A 6f8cA-3nvyA:
undetectable		 6f8cA-3nvyA:
20.86