SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE A 577
ALA A 560
GLY A 521
ILE A 522
LEU A 572
 None
 1.20A 1kglA-3nwcA:
undetectable		 1kglA-3nwcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		4 / 8 VAL A 610
TYR A 602
ASP A 598
LEU A 545
 None
 1.23A 1pk2A-3nwcA:
undetectable		 1pk2A-3nwcA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 575
SER A 517
ILE A 519
VAL A 554
LEU A 572
 None
 1.17A 2japA-3nwcA:
undetectable		 2japA-3nwcA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 575
SER A 517
ILE A 519
VAL A 554
LEU A 572
 None
 1.21A 2japB-3nwcA:
undetectable		 2japB-3nwcA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 575
SER A 517
ILE A 519
VAL A 554
LEU A 572
 None
 1.14A 2japC-3nwcA:
undetectable		 2japC-3nwcA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 575
SER A 517
ILE A 519
VAL A 554
LEU A 572
 None
 1.17A 2japD-3nwcA:
undetectable		 2japD-3nwcA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3nwc SMC PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 539
VAL A 543
ALA A 544
LEU A 545
ALA A 613
 None
 0.73A 5kpcA-3nwcA:
undetectable		 5kpcA-3nwcA:
18.00