SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3nwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 5 VAL A 314
ASN A 316
VAL A  69
ILE A 115
 None
 1.06A 1z2bC-3nwnA:
undetectable		 1z2bC-3nwnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 7 PHE A 192
GLU A 188
GLN A 121
TYR A  70
 None
UNX  A1007 ( 4.8A)
None
None
 1.38A 2aoxB-3nwnA:
2.2		 2aoxB-3nwnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 6 TRP A  53
ILE A  35
LEU A 331
LEU A  37
 None
 1.05A 2rlfA-3nwnA:
undetectable
2rlfD-3nwnA:
undetectable		 2rlfA-3nwnA:
11.76
2rlfD-3nwnA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 7 LEU A 142
SER A 140
TYR A 223
THR A 221
 UNX  A1005 ( 4.4A)
UNX  A1005 ( 2.9A)
None
UNX  A1005 ( 3.9A)
 0.95A 2uz2A-3nwnA:
undetectable		 2uz2A-3nwnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 LEU A 116
ALA A 191
THR A 185
VAL A 137
GLU A 197
 None
 0.98A 3cwkA-3nwnA:
undetectable		 3cwkA-3nwnA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 5 ASP A 245
ARG A  12
ILE A 115
VAL A 312
 MG  A 402 ( 4.0A)
ADP  A 401 (-3.5A)
None
None
 1.22A 3eigA-3nwnA:
undetectable		 3eigA-3nwnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		3 / 3 ASN A 146
MET A 166
PHE A 150
 None
 0.80A 3g4lD-3nwnA:
undetectable		 3g4lD-3nwnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 GLU A 326
SER A 249
SER A 329
SER A 330
VAL A  11
 None
 1.33A 3rfaB-3nwnA:
undetectable		 3rfaB-3nwnA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 GLY A  93
GLY A 248
SER A 329
ALA A  97
TYR A 318
 None
None
None
ADP  A 401 (-4.6A)
None
 1.00A 3sxjA-3nwnA:
undetectable		 3sxjA-3nwnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 GLY A  93
GLY A 248
SER A 329
ALA A  97
TYR A 318
 None
None
None
ADP  A 401 (-4.6A)
None
 1.01A 3sxjB-3nwnA:
undetectable		 3sxjB-3nwnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 GLY A  93
GLY A 248
SER A 329
ALA A  97
TYR A 318
 None
None
None
ADP  A 401 (-4.6A)
None
 1.16A 3t7sC-3nwnA:
undetectable		 3t7sC-3nwnA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		3 / 3 TYR A 223
MET A 311
LEU A 301
 None
 0.43A 3vw1D-3nwnA:
undetectable		 3vw1D-3nwnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 4 ASN A 269
ALA A 247
GLY A 248
THR A  95
 None
None
None
ADP  A 401 (-4.0A)
 1.27A 4bboC-3nwnA:
undetectable		 4bboC-3nwnA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 5 CYH A 295
LEU A 275
SER A 271
LEU A 301
 None
 1.14A 4n09D-3nwnA:
undetectable		 4n09D-3nwnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		4 / 7 VAL A 123
ILE A 127
VAL A 137
ILE A 222
 None
 0.73A 5bmvC-3nwnA:
undetectable		 5bmvC-3nwnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		3 / 3 LEU A 324
ILE A  35
TYR A  26
 None
 0.56A 5uunB-3nwnA:
undetectable		 5uunB-3nwnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		5 / 12 LEU A 246
LEU A 313
PHE A 333
ILE A 279
THR A 298
 None
 1.10A 6debB-3nwnA:
undetectable		 6debB-3nwnA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens) 		3 / 3 GLN A  80
TYR A  85
ASN A 310
 None
 0.97A 6dwdC-3nwnA:
undetectable		 6dwdC-3nwnA:
23.16